Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. Interacts with EFEMP1. Belongs to the protease inhibitor I35 (TIMP) family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis
Molecular Function: metalloendopeptidase inhibitor activity; protein binding; protease binding; metal ion binding
Biological Process: negative regulation of metalloenzyme activity; central nervous system development; visual perception; response to mechanical stimulus; tissue regeneration; response to estrogen stimulus; response to cytokine stimulus; response to folic acid; response to hormone stimulus; negative regulation of membrane protein ectodomain proteolysis; aging
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.