Home

TG (human)

Overview TG Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Defects in TG are the cause of thyroid dyshormonogenesis 3 (TDH3). A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases. Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3). AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Secreted; Secreted, signal peptide Cellular Component: Golgi apparatus; extracellular space; cell surface; perinuclear region of cytoplasm; endoplasmic reticulum; integral to plasma membrane; extracellular region; synapse Molecular Function: chaperone binding; neurexin binding; hormone activity; receptor activity; carboxylesterase activity Biological Process: synaptogenesis; regulation of myelination; iodide transport; thyroid gland development; thyroid hormone generation; response to lipopolysaccharide; transcytosis; hormone biosynthetic process; signal transduction; response to pH Reference #:  P01266 (UniProtKB) Alt. Names/Synonyms: AITD3; TG; TGN; THYG; Thyroglobulin Gene Symbols: TG Molecular weight: 304,790 Da Basal Isoelectric point: 5.4  Predict pI for various phosphorylation states

Select Structure to View Below TG

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 188450 608175  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		Y234-p	RFPEVSGyCHCADsQ
0	1		S240-p	GyCHCADsQGRELAE
0	1		Y376-p	QQALSRLyFGTSGYF
0	1		T939-p	VLQFIREtEEIVSAS
0	1		Q985	PREAFAEQFLRGSDY
0	1		Y1005-p	AQSTLSFyQRRRFSP
0	1		Y1165-p	SRRVSPGyVPACRAE
0	1		Y1529-p	QCDQNGQyRASQKDR
0	1		S1577-p	KFEKVPEsKVIFDAN
0	1		S1591-p	NAPVAVRsKVPDSEF
0	1		S1659	SKATSFGSLRCQVKV
0	1		L2090	SLTEKVSLDSWQSLA
0	1		S2095	VSLDSWQSLALSSVV
0	1		S2099	SWQSLALSSVVVDPS
0	1		Y2184-p	REEATHIyRKPGISL
0	1		S2258	WTGSWDASKPRASCW
0	1		T2467-p	NVLNDAQtKLLAVSG
0	1		S2529	AVKQFEESRGRTSSK
0	2		Y2658-p	LSLKIMQyFSHFIRS
0	1		Y2670-p	IRSGNPNyPYEFSRK
0	1		Y2721-p	DCSFWSKyISSLKTs
0	1		S2728-p	yISSLKTsADGAKGG
0	1		S2737-p	DGAKGGQsAEsEEEE
0	1		S2740-p	KGGQsAEsEEEELTA

	mouse
Y235	RFPEVSGYCYCADSQ
S241	GYCYCADSQGRELAE
Y377	QQALSRFYFETPDYF
T940	VLKFIKETEEIVSAS
K986-a	SRDAFSEkFLRGGEY
Y1006	AQSTLTFYQSLRASL
Y1166	SRKVGLGYSPVCEAL
Y1528	QCDQNGQYQASQKNR
S1576	KFDKAPESKVIFDAN
-	under review
S1658-p	LKATSFGsLRCQVKV
S2088-p	LTEEKVTsDSWQtLA
T2093-p	VTsDSWQtLALsSVI
S2097-p	SWQtLALsSVIVDPS
Y2182	HEEATYIYRKSGIPL
T2257-p	WTGSWDAtKPRASCW
T2466	NILNDAQTKLLAVSG
S2528-p	AVKQFEEsQGRTNSK
Y2657	LSLKVMQYFSNFIRS
Y2669	IRSGNPNYPHEFSRK
Y2720	DCSFWSKYIQTLKDA
D2726	KYIQTLKDADGAKDA
L2735	DGAKDAQLTKSEEED
-	under review

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.