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Protein Page:
TG (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TG Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Defects in TG are the cause of thyroid dyshormonogenesis 3 (TDH3). A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases. Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3). AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 8q24
Cellular Component: extracellular space; cell surface; integral to plasma membrane; extracellular region; synapse
Molecular Function: hormone activity; neurexin binding; receptor activity
Biological Process: regulation of myelination; synaptogenesis; iodide transport; thyroid gland development; thyroid hormone generation; hormone biosynthetic process; signal transduction
Reference #:  P01266 (UniProtKB)
Alt. Names/Synonyms: AITD3; TG; TGN; THYG; Thyroglobulin
Gene Symbols: TG
Molecular weight: 304,790 Da
Basal Isoelectric point: 5.4  Predict pI for various phosphorylation states
Select Structure to View Below

TG

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y234-p RFPEVSGyCHCADsQ
0 1 S240-p GyCHCADsQGRELAE
0 1 Y376-p QQALSRLyFGTSGYF
0 1 T939-p VLQFIREtEEIVSAS
0 1 Q985 PREAFAEQFLRGSDY
0 1 Y1005-p AQSTLSFyQRRRFSP
0 1 Y1165-p SRRVSPGyVPACRAE
0 1 T1421-p SKTFPAEtIRFLQGD
0 1 Y1529-p QCDQNGQyRASQKDR
0 1 S1577-p KFEKVPEsKVIFDAN
0 1 S1591-p NAPVAVRsKVPDSEF
0 1 S1659 SKATSFGSLRCQVKV
0 1 L2090 SLTEKVSLDSWQSLA
0 1 S2095 VSLDSWQSLALSSVV
0 1 S2099 SWQSLALSSVVVDPS
0 1 Y2184-p REEATHIyRKPGISL
0 1 S2258 WTGSWDASKPRASCW
0 1 T2467-p NVLNDAQtKLLAVSG
0 1 S2529 AVKQFEESRGRTSSK
0 2 Y2658-p LSLKIMQyFSHFIRS
0 1 Y2670-p IRSGNPNyPYEFSRK
0 1 Y2721-p DCSFWSKyISSLKTs
0 1 S2728-p yISSLKTsADGAKGG
0 1 S2737-p DGAKGGQsAEsEEEE
0 1 S2740-p KGGQsAEsEEEELTA
  mouse

 
Y235 RFPEVSGYCYCADSQ
S241 GYCYCADSQGRELAE
Y377 QQALSRFYFETPDYF
T940 VLKFIKETEEIVSAS
K986-ac SRDAFSEkFLRGGEY
Y1006 AQSTLTFYQSLRASL
Y1166 SRKVGLGYSPVCEAL
T1421 SKTFSADTTLYFLNG
Y1528 QCDQNGQYQASQKNR
S1576 KFDKAPESKVIFDAN
S1590 NSPVIVKSSVPSADS
S1658-p LKATSFGsLRCQVKV
S2088-p LTEEKVTsDSWQtLA
T2093-p VTsDSWQtLALsSVI
S2097-p SWQtLALsSVIVDPS
Y2182 HEEATYIYRKSGIPL
T2257-p WTGSWDAtKPRASCW
T2466 NILNDAQTKLLAVSG
S2528-p AVKQFEEsQGRTNSK
Y2657 LSLKVMQYFSNFIRS
Y2669 IRSGNPNYPHEFSRK
Y2720 DCSFWSKYIQTLKDA
D2726 KYIQTLKDADGAKDA
L2735 DGAKDAQLTKSEEED
S2738 KDAQLTKSEEEDLEV
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