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Protein Page:
TG (human)

Overview
TG Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Defects in TG are the cause of thyroid dyshormonogenesis 3 (TDH3). A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases. Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3). AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Cellular Component: extracellular space; cell surface; integral to plasma membrane; extracellular region; synapse
Molecular Function: neurexin binding; hormone activity; receptor activity
Biological Process: regulation of myelination; synaptogenesis; iodide transport; thyroid gland development; thyroid hormone generation; hormone biosynthetic process; signal transduction
Reference #:  P01266 (UniProtKB)
Alt. Names/Synonyms: AITD3; TG; TGN; THYG; Thyroglobulin
Gene Symbols: TG
Molecular weight: 304,790 Da
Basal Isoelectric point: 5.4  Predict pI for various phosphorylation states
Select Structure to View Below

TG

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y234-p RFPEVSGyCHCADSQ
0 1 S1659 SKATSFGSLRCQVKV
0 1 L2090 SLTEKVSLDSWQSLA
0 1 S2095 VSLDSWQSLALSSVV
0 1 S2099 SWQSLALSSVVVDPS
0 1 S2258 WTGSWDASKPRASCW
0 2 Y2658-p LSLKIMQyFSHFIRS
0 1 Y2721-p DCSFWSKyISSLKTs
0 1 S2728-p yISSLKTsADGAKGG
  mouse

 
Y235 RFPEVSGYCYCADSQ
S1658-p LKATSFGsLRCQVKV
S2088-p LTEEKVTsDSWQtLA
T2093-p VTsDSWQtLALsSVI
S2097-p SWQtLALsSVIVDPS
T2257-p WTGSWDAtKPRASCW
Y2657 LSLKVMQYFSNFIRS
Y2720 DCSFWSKYIQTLKDA
D2726 KYIQTLKDADGAKDA
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