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TGFB3 (human)

Overview TGFB3 Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Ligand, receptor tyrosine kinase; Secreted; Cell development/differentiation; Secreted, signal peptide Cellular Component: extracellular matrix; extracellular space; cell surface; cell soma; T-tubule; extracellular region; plasma membrane; nucleus Molecular Function: identical protein binding; protein binding; growth factor activity; protein heterodimerization activity; transforming growth factor beta binding; punt binding Biological Process: activation of MAPK activity; positive regulation of transcription, DNA-dependent; positive regulation of collagen biosynthetic process; palate development; female pregnancy; SMAD protein nuclear translocation; odontogenesis; negative regulation of cell proliferation; platelet degranulation; mammary gland development; transforming growth factor beta receptor signaling pathway; salivary gland morphogenesis; embryonic neurocranium morphogenesis; negative regulation of neuron apoptosis; cell growth; inner ear development; aging; positive regulation of filopodium formation; platelet activation; intercellular junction assembly and maintenance; menstrual cycle phase; in utero embryonic development; positive regulation of bone mineralization; gut development; positive regulation of protein secretion; negative regulation of DNA replication; response to estrogen stimulus; positive regulation of cell division; induction of apoptosis; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; response to progesterone stimulus; blood coagulation; alveolus development; positive regulation of DNA replication Reference #:  P10600 (UniProtKB) Alt. Names/Synonyms: ARVD; FLJ16571; TGF-beta-3; TGF-beta3; TGFB3; Transforming growth factor beta-3; transforming growth factor, beta 3 Gene Symbols: TGFB3 Molecular weight: 47,328 Da Basal Isoelectric point: 8.31  Predict pI for various phosphorylation states CST Pathways:  Signaling Pathways Activating p38 MAPK  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TGFB3 1KTZ - A=301-412 (human) 1TGJ - A=301-412 (human) 1TGK - A=301-412 (human) 2PJY - A=301-412 (human) 3EO1 - F/C/I/L=301-412 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1KTZ 1TGJ 1TGK 2PJY 3EO1  |  Phospho3D  |  DISEASE 107970 190230  |  InnateDB  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T54	ILSKLRLTSPPEPTV
0	1		S55	LSKLRLTSPPEPTVM
0	1		Y67	TVMTHVPYQVLALYN
0	2		Y185-p	EHIAKQRyIGGKNLP
0	1		K299-a	GQGGQRKkRALDTNY

	mouse
T52-p	ILSKLRLtsPPEPSV
S53-p	LSKLRLtsPPEPSVM
Y65-p	SVMTHVPyQVLALYN
Y183	EHIAKQRYIGGKNLP
K297	GQGSQRKKRALDTNY

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