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Protein Page:
TGFB3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TGFB3 Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; Ligand, receptor tyrosine kinase
Chromosomal Location of Human Ortholog: 14q24
Cellular Component: extracellular matrix; extracellular space; cell surface; cell soma; T-tubule; plasma membrane; extracellular region; nucleus
Molecular Function: identical protein binding; protein binding; growth factor activity; protein heterodimerization activity; transforming growth factor beta binding; punt binding
Biological Process: extracellular matrix organization and biogenesis; positive regulation of apoptosis; activation of MAPK activity; positive regulation of transcription, DNA-dependent; positive regulation of collagen biosynthetic process; female pregnancy; palate development; SMAD protein nuclear translocation; odontogenesis; negative regulation of cell proliferation; platelet degranulation; mammary gland development; transforming growth factor beta receptor signaling pathway; salivary gland morphogenesis; embryonic neurocranium morphogenesis; negative regulation of neuron apoptosis; cell growth; inner ear development; aging; positive regulation of filopodium formation; intercellular junction assembly and maintenance; platelet activation; menstrual cycle phase; in utero embryonic development; positive regulation of bone mineralization; gut development; positive regulation of protein secretion; response to estrogen stimulus; negative regulation of DNA replication; positive regulation of cell division; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; negative regulation of transforming growth factor beta receptor signaling pathway; response to progesterone stimulus; alveolus development; positive regulation of DNA replication
Reference #:  P10600 (UniProtKB)
Alt. Names/Synonyms: ARVD; FLJ16571; TGF-beta-3; TGF-beta3; TGFB3; Transforming growth factor beta-3; transforming growth factor, beta 3
Gene Symbols: TGFB3
Molecular weight: 47,328 Da
Basal Isoelectric point: 8.31  Predict pI for various phosphorylation states
CST Pathways:  Regulation of P38 MAPKs  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TGFB3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T54 ILSKLRLTSPPEPTV
0 1 S55 LSKLRLTSPPEPTVM
0 1 Y67 TVMTHVPYQVLALYN
0 1 K162-m3 RVPNPSSkRNEQRIE
0 2 Y185-p EHIAKQRyIGGKNLP
0 1 K299-ac GQGGQRKkRALDTNY
  mouse

 
T52-p ILSKLRLtsPPEPSV
S53-p LSKLRLtsPPEPSVM
Y65-p SVMTHVPyQVLALYN
K160 RVPNPSSKRTEQRIE
Y183 EHIAKQRYIGGKNLP
K297 GQGSQRKKRALDTNY
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