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Protein Page:
TGFB3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TGFB3 Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Cell development/differentiation; Ligand, receptor tyrosine kinase; Motility/polarity/chemotaxis; Secreted, signal peptide
Cellular Component: extracellular matrix; extracellular space; cell surface; cell soma; T-tubule; extracellular region; plasma membrane; nucleus
Molecular Function: identical protein binding; protein binding; growth factor activity; transforming growth factor beta binding; protein heterodimerization activity; punt binding
Biological Process: extracellular matrix organization and biogenesis; positive regulation of apoptosis; activation of MAPK activity; positive regulation of transcription, DNA-dependent; positive regulation of collagen biosynthetic process; SMAD protein nuclear translocation; female pregnancy; palate development; odontogenesis; negative regulation of cell proliferation; platelet degranulation; mammary gland development; transforming growth factor beta receptor signaling pathway; salivary gland morphogenesis; embryonic neurocranium morphogenesis; negative regulation of neuron apoptosis; cell growth; inner ear development; aging; positive regulation of filopodium formation; intercellular junction assembly and maintenance; platelet activation; menstrual cycle phase; in utero embryonic development; positive regulation of bone mineralization; positive regulation of protein secretion; gut development; negative regulation of DNA replication; response to estrogen stimulus; positive regulation of cell division; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; negative regulation of transforming growth factor beta receptor signaling pathway; response to progesterone stimulus; alveolus development; positive regulation of DNA replication
Reference #:  P10600 (UniProtKB)
Alt. Names/Synonyms: ARVD; FLJ16571; TGF-beta-3; TGF-beta3; TGFB3; Transforming growth factor beta-3; transforming growth factor, beta 3
Gene Symbols: TGFB3
Molecular weight: 47,328 Da
Basal Isoelectric point: 8.31  Predict pI for various phosphorylation states
CST Pathways:  Regulation of P38 MAPKs  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TGFB3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K162-m3 RVPNPSSkRNEQRIE
0 2 Y185-p EHIAKQRyIGGKNLP
  mouse

 
K160 RVPNPSSKRTEQRIE
Y183 EHIAKQRYIGGKNLP
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