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TGFB2 (human)

Overview TGFB2 TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth. Homodimer; disulfide-linked. Heterodimers with TGFB1 and with TGFB3 have been found in bone. Interacts with the serine proteases, HTRA1 and HTRA3. Interacts with ASPN. Belongs to the TGF-beta family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Secreted; Cell development/differentiation; Secreted, signal peptide Cellular Component: extracellular matrix; extracellular space; cell surface; cell soma; axon; extracellular region; basement membrane; trans-Golgi network Molecular Function: protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity; beta-amyloid binding; punt binding; cytokine activity; protein N-terminus binding; transforming growth factor beta receptor binding; receptor binding; receptor signaling protein serine/threonine kinase activity Biological Process: heart morphogenesis; collagen fibril organization; catagen; positive regulation of apoptosis; heart development; SMAD protein nuclear translocation; female pregnancy; dopamine biosynthetic process; protein amino acid phosphorylation; response to vitamin D; cell-cell signaling; hair follicle development; transforming growth factor beta receptor signaling pathway; somatic stem cell division; cell growth; kidney development; cell cycle arrest; embryonic gut development; inner ear development; hindbrain development; cartilage condensation; response to drug; platelet activation; neutrophil chemotaxis; skeletal muscle development; menstrual cycle phase; negative regulation of immune response; neuron fate commitment; positive regulation of cell cycle; positive regulation of catagen; response to organic nitrogen; positive regulation of cell growth; positive regulation of phosphoinositide 3-kinase cascade; cardioblast differentiation; positive regulation of protein secretion; positive regulation of cell division; activation of protein kinase activity; neuron development; response to progesterone stimulus; positive regulation of heart contraction; negative regulation of apoptosis; cell death; axon guidance; positive regulation of immune response; wound healing; cell morphogenesis; cardiac muscle cell proliferation; positive regulation of stress-activated MAPK cascade; response to estradiol stimulus; odontogenesis; negative regulation of cell proliferation; response to radiation; platelet degranulation; positive regulation of neuron apoptosis; negative regulation of release of sequestered calcium ion into cytosol; salivary gland morphogenesis; pancreas development; positive regulation of cell proliferation; response to wounding; thyroid gland development; embryonic neurocranium morphogenesis; hemopoiesis; positive regulation of integrin biosynthetic process; angiogenesis; activated T cell apoptosis; aging; negative regulation of epithelial cell proliferation; intercellular junction assembly and maintenance; cell migration; regulation of transforming growth factor-beta2 production; response to retinoic acid; hair follicle morphogenesis; positive regulation of cell adhesion mediated by integrin; glial cell migration; positive regulation of ossification; cell proliferation; embryonic development; eye development; generation of neurons; response to cytokine stimulus; induction of apoptosis; positive regulation of cardioblast differentiation; response to hypoxia; epithelial to mesenchymal transition; blood vessel remodeling; response to cold; negative regulation of cell growth; blood coagulation Reference #:  P61812 (UniProtKB) Alt. Names/Synonyms: BSC-1 cell growth inhibitor; Cetermin; G-TSF; Glioblastoma-derived T-cell suppressor factor; MGC116892; Polyergin; TGF-beta-2; TGF-beta2; TGFB2; Transforming growth factor beta-2; transforming growth factor, beta 2 Gene Symbols: TGFB2 Molecular weight: 47,748 Da Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states CST Pathways:  Signaling Pathways Activating p38 MAPK  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TGFB2 1TFG - A=303-414 (human) 2TGI - A=303-414 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1TFG 2TGI  |  Phospho3D  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y98-p	RERSDEEyYAKEVYK
0	1		Y123-p	NAIPPTFyRPYFRIV
0	1		Y341-p	WIHEPKGyNANFCAG
0	1		Y352-p	FCAGACPyLWSSDTQ
0	1		S404-p	TPKIEQLsNMIVKSC

	mouse
Y98	RERSDEEYYAKEVYK
Y123	NAIPPTFYRPYFRIV
Y341	WIHEPKGYNANFCAG
Y352	FCAGACPYLWSSDTQ
S404	TPKIEQLSNMIVKSC

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