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Protein Page:
TGFB2 (human)

Overview
TGFB2 TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth. Homodimer; disulfide-linked. Heterodimers with TGFB1 and with TGFB3 have been found in bone. Interacts with the serine proteases, HTRA1 and HTRA3. Interacts with ASPN. Belongs to the TGF-beta family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted; Cell development/differentiation; Motility/polarity/chemotaxis; Secreted, signal peptide
Cellular Component: extracellular matrix; extracellular space; cell soma; axon; extracellular region
Molecular Function: protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity; beta-amyloid binding; punt binding; cytokine activity; transforming growth factor beta receptor binding; receptor signaling protein serine/threonine kinase activity; receptor binding
Biological Process: heart morphogenesis; extracellular matrix organization and biogenesis; catagen; collagen fibril organization; heart development; dopamine biosynthetic process; SMAD protein nuclear translocation; protein amino acid phosphorylation; cell-cell signaling; hair follicle development; transforming growth factor beta receptor signaling pathway; somatic stem cell division; cell growth; cell cycle arrest; embryonic gut development; cartilage condensation; response to drug; platelet activation; neutrophil chemotaxis; menstrual cycle phase; negative regulation of immune response; neuron fate commitment; positive regulation of cell cycle; positive regulation of catagen; positive regulation of cell growth; positive regulation of phosphoinositide 3-kinase cascade; cardioblast differentiation; positive regulation of protein secretion; positive regulation of cell division; activation of protein kinase activity; neuron development; response to progesterone stimulus; positive regulation of heart contraction; cell death; axon guidance; positive regulation of immune response; wound healing; cell morphogenesis; cardiac muscle cell proliferation; positive regulation of stress-activated MAPK cascade; odontogenesis; negative regulation of cell proliferation; platelet degranulation; positive regulation of neuron apoptosis; positive regulation of cell proliferation; salivary gland morphogenesis; response to wounding; hemopoiesis; positive regulation of integrin biosynthetic process; angiogenesis; negative regulation of epithelial cell proliferation; intercellular junction assembly and maintenance; regulation of transforming growth factor-beta2 production; cell migration; hair follicle morphogenesis; positive regulation of cell adhesion mediated by integrin; glial cell migration; positive regulation of ossification; cell proliferation; embryonic development; eye development; generation of neurons; positive regulation of cardioblast differentiation; response to hypoxia; epithelial to mesenchymal transition; blood vessel remodeling; negative regulation of cell growth; blood coagulation
Reference #:  P61812 (UniProtKB)
Alt. Names/Synonyms: BSC-1 cell growth inhibitor; Cetermin; G-TSF; Glioblastoma-derived T-cell suppressor factor; MGC116892; Polyergin; TGF-beta-2; TGF-beta2; TGFB2; Transforming growth factor beta-2; transforming growth factor, beta 2
Gene Symbols: TGFB2
Molecular weight: 47,748 Da
Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states
CST Pathways:  Regulation of P38 MAPKs  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TGFB2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y98-p RERSDEEyYAKEVYK
0 1 Y123-p NAIPPTFyRPYFRIV
0 1 Y341-p WIHEPKGyNANFCAG
0 1 Y352-p FCAGACPyLWSSDTQ
0 1 S404-p TPKIEQLsNMIVKSC
  mouse

 
Y98 RERSDEEYYAKEVYK
Y123 NAIPPTFYRPYFRIV
Y341 WIHEPKGYNANFCAG
Y352 FCAGACPYLWSSDTQ
S404 TPKIEQLSNMIVKSC
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