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AP-2 beta (human)

Overview AP-2 beta Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. Belongs to the AP-2 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Transcription factor; DNA binding protein Cellular Component: nucleus Molecular Function: protein dimerization activity; protein binding; protein homodimerization activity; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; caspase inhibitor activity; transcription coactivator activity; transcription corepressor activity; transcription factor activity Biological Process: skin development; fat cell differentiation; hindlimb morphogenesis; positive regulation of transcription, DNA-dependent; regulation of BMP signaling pathway; negative regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; glucose homeostasis; calcium ion homeostasis; forelimb morphogenesis; negative regulation of cell proliferation; sympathetic nervous system development; regulation of transcription, DNA-dependent; positive regulation of neuron apoptosis; regulation of cell differentiation; positive regulation of cell proliferation; sodium ion homeostasis; phosphate ion homeostasis; kidney development; potassium ion homeostasis; glucose metabolic process; renal water homeostasis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; regulation of insulin secretion; negative regulation of apoptosis Reference #:  Q92481 (UniProtKB) Alt. Names/Synonyms: activating enhancer binding protein 2 beta; Activating enhancer-binding protein 2-beta; AP-2B; AP2-B; AP2-beta; AP2B; MGC21381; TFAP2B; transcription factor AP-2 beta (activating enhancer binding protein 2 beta); Transcription factor AP-2-beta Gene Symbols: TFAP2B Molecular weight: 50,474 Da Basal Isoelectric point: 8.41  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below AP-2 beta

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 169100 601601  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K15-u	QAAIMLWkLVENVKY
0	1		Y26-p	NVKYEDIyEDRHDGV
0	1		S120-p	EVGSEAGsLLPQPRA
0	2		S258-p	GEVQRRLsPPECLNA
0	1		R282	AKSKNGGRSLRERLE

	mouse
K15	QAAIMLWKLVENVKY
Y26	NVKYEDIYEDRHDGV
S120	EVGSEAGSLLPQPRA
S258-p	GEVQRRLsPPECLNA
R282-m1	AKSKNGGrSLRERLE

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