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Protein Page:
EDARADD (human)

Overview
EDARADD Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF- kappa-B. Defects in EDARADD are a cause of ectodermal dysplasia anhidrotic (EDA); also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: cytoplasm
Biological Process: hair follicle development; signal transduction; cell differentiation; odontogenesis of dentine-containing teeth
Reference #:  Q8WWZ3 (UniProtKB)
Alt. Names/Synonyms: crinkled; ectodysplasia A receptor associated death domain; ectodysplasin A receptor associated adapter protein; ED3; EDA3; EDAR-associated death domain; EDAR-associated death domain protein; EDARADD; OTTHUMP00000037857; OTTHUMP00000037858; Q8WWZ3
Gene Symbols: EDARADD
Molecular weight: 24,802 Da
Basal Isoelectric point: 5.23  Predict pI for various phosphorylation states
Select Structure to View Below

EDARADD

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T5-p ___MGLRtTKQMGRG
0 1 - gap
  EDARADD iso5  
- gap
Y44-p SGASTGIyEVLELQD
  mouse

 
- gap
- gap
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