Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
PLA2G1B (human)

PLA2G1B PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Belongs to the phospholipase A2 family. Note: This description may include information from UniProtKB.
Protein type: Lipid Metabolism - linoleic acid; Lipid Metabolism - alpha-linolenic acid; DNA replication; EC; Lipid Metabolism - glycerophospholipid; Secreted, signal peptide; Secreted; Phospholipase; Lipid Metabolism - ether lipid; Lipid Metabolism - arachidonic acid
Cellular Component: extracellular space; cell surface; extracellular region; secretory granule
Molecular Function: phospholipase A2 activity; calcium-dependent phospholipase A2 activity; bile acid binding; calcium ion binding; receptor binding
Biological Process: positive regulation of immune response; activation of MAPK activity; neutrophil mediated immunity; activation of phospholipase A2; glucose transport; signal transduction; phosphatidylcholine metabolic process; activation of NF-kappaB transcription factor; positive regulation of fibroblast proliferation; phospholipid metabolic process; fatty acid biosynthetic process; multicellular organismal lipid catabolic process; neutrophil chemotaxis; glycerophospholipid biosynthetic process; actin filament organization; arachidonic acid secretion; leukotriene biosynthetic process; defense response to Gram-positive bacterium; innate immune response in mucosa; positive regulation of protein secretion; cellular response to insulin stimulus; antibacterial humoral response; phosphatidic acid biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; interleukin-8 production; positive regulation of DNA replication
Reference #:  P04054 (UniProtKB)
Alt. Names/Synonyms: Group IB phospholipase A2; MGC119834; MGC119835; PA21B; Phosphatidylcholine 2-acylhydrolase 1B; Phospholipase A2; phospholipase A2, group IB (pancreas); PLA2; PLA2A; PLA2G1B; PPLA2
Gene Symbols: PLA2G1B
Molecular weight: 16,360 Da
Basal Isoelectric point: 8.16  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

Show Multiple Sequence Alignment


SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.



Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.