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PLA2G1B (human)

Overview PLA2G1B PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Belongs to the phospholipase A2 family. Note: This description may include information from UniProtKB. Protein type: Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Lipid Metabolism - ether lipid; Phospholipase; Secreted, signal peptide; EC 3.1.1.4; DNA replication; Secreted; Lipid Metabolism - arachidonic acid Cellular Component: extracellular space; extracellular region; secretory granule Molecular Function: phospholipase A2 activity; calcium-dependent phospholipase A2 activity; bile acid binding; calcium ion binding; cell surface binding; receptor binding Biological Process: multicellular organismal lipid catabolic process; neutrophil chemotaxis; positive regulation of immune response; activation of MAPK activity; glycerophospholipid biosynthetic process; neutrophil mediated immunity; activation of phospholipase A2; protein kinase cascade; actin filament organization; glucose transport; signal transduction; arachidonic acid secretion; activation of NF-kappaB transcription factor; phosphatidylcholine metabolic process; leukotriene biosynthetic process; positive regulation of fibroblast proliferation; positive regulation of protein secretion; cellular response to insulin stimulus; phospholipid metabolic process; phosphatidic acid biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; fatty acid biosynthetic process; positive regulation of DNA replication; interleukin-8 production Reference #:  P04054 (UniProtKB) Alt. Names/Synonyms: Group IB phospholipase A2; MGC119834; MGC119835; PA21B; Phosphatidylcholine 2-acylhydrolase 1B; Phospholipase A2; phospholipase A2, group IB (pancreas); PLA2; PLA2A; PLA2G1B; PPLA2 Gene Symbols: PLA2G1B Molecular weight: 16,360 Da Basal Isoelectric point: 8.16  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PLA2G1B 1YSK - A=23-146 (human) 3ELO - A=16-148 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1YSK 3ELO  |  ENZYME  |  Phospho3D  |  DISEASE  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y95-p	DNPYTHTySySCSGS
0	1		Y97-p	PYTHTySySCSGSAI

	mouse
Y95	DNPYTNTYSYSCSGS
Y97	PYTNTYSYSCSGSEI

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