a receptor tyrosine kinase. Receptor for members of the ephrin-A family. Binds with a low affinity to ephrin-A1. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. Misexpressed in several cancers, including upregulation in head and neck cancer, and downregulation in invasive breast cancer cell lines and glioblastoma Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; EC 18.104.22.168; Protein kinase, tyrosine (receptor); Kinase, protein; Membrane protein, integral; TK group; Eph family
Chromosomal Location of Human Ortholog: 7q34
Cellular Component: integral to plasma membrane
Molecular Function: transmembrane-ephrin receptor activity; protein kinase binding; ATP binding; protein kinase activity
Biological Process: peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; activation of Rho GTPase; positive regulation of angiogenesis; cell surface receptor linked signal transduction; positive regulation of cell proliferation; positive regulation of stress fiber formation; ephrin receptor signaling pathway; negative regulation of protein kinase activity; angiogenesis; positive regulation of cell-matrix adhesion; negative regulation of cell migration; regulation of Rac GTPase activity; positive regulation of cell migration
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.