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Protein Page:
PAX5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PAX5 May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene. Interacts with DAXX. Binds DNA as a monomer. Binds TLE4. Note: This description may include information from UniProtKB.
Cellular Component: nucleus
Molecular Function: protein binding; DNA binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; negative regulation of histone H3-K9 methylation; nervous system development; organ morphogenesis; multicellular organismal development; spermatogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; humoral immune response
Reference #:  Q02548 (UniProtKB)
Alt. Names/Synonyms: B cell specific activator protein; B-cell lineage specific activator; B-cell-specific transcription factor; BSAP; paired box 5; paired box homeotic gene 5; Paired box protein Pax-5; PAX5; transcription factor PAX 5
Gene Symbols: PAX5
Molecular weight: 42,149 Da
Basal Isoelectric point: 9.08  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PAX5

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y7-p _MDLEKNyPTPRTSR
0 1 Y102-p VVEKIAEyKRQNPTM
0 1 S168-p TGSVTQVsSVSTDSA
0 1 Y179-p TDSAGSSysISGILG
0 1 S180-p DSAGSSysISGILGI
0 1 S206-p RDEGIQEsPVPNGHS
0 1 R225 DFLRKQMRGDLFTQQ
0 1 R243 VLDRVFERQHYSDIF
0 1 S298-p SSVPGPQsyPIVTGR
0 1 Y299-p SVPGPQsyPIVTGRD
  mouse

 
Y7 _MDLEKNYPTPRTIR
Y102 VVEKIAEYKRQNPTM
S168 TGSVTQVSSVSTDSA
Y179 TDSAGSSYSISGILG
S180 DSAGSSYSISGILGI
S206 RDEGIQESPVPNGHS
R225-m1 DFLRKQMrGDLFTQQ
R243-m1 VLDRVFErQHYSDIF
S298 SSVPGPQSYPIVTGR
Y299 SVPGPQSYPIVTGRD
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