This tyrosine kinase receptor for fibrillar collagen mediates fibroblast migration and proliferation. Contributes to cutaneous wound healing. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Kinase, protein; EC 184.108.40.206; TK group; DDR family
Cellular Component: focal adhesion; integral to plasma membrane; apical plasma membrane; plasma membrane
Molecular Function: collagen binding; protein binding; transmembrane receptor protein tyrosine kinase activity; ATP binding
Biological Process: positive regulation of osteoblast differentiation; positive regulation of fibroblast proliferation; extracellular matrix organization and biogenesis; ossification; peptidyl-tyrosine phosphorylation; collagen fibril organization; biomineral formation; protein amino acid autophosphorylation; positive regulation of protein kinase activity; positive regulation of transcription factor activity; signal transduction; cell adhesion; regulation of bone mineralization
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.