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DDR2 (human)

Overview DDR2 This tyrosine kinase receptor for fibrillar collagen mediates fibroblast migration and proliferation. Contributes to cutaneous wound healing. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Note: This description may include information from UniProtKB. Protein type: Protein kinase, TK; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Membrane protein, integral; Kinase, protein; EC 2.7.1.112; TK group; DDR family Cellular Component: integral to plasma membrane Molecular Function: collagen binding; transmembrane receptor protein tyrosine kinase activity; ATP binding Biological Process: positive regulation of osteoblast differentiation; positive regulation of fibroblast proliferation; ossification; collagen fibril organization; peptidyl-tyrosine phosphorylation; biomineral formation; protein amino acid autophosphorylation; positive regulation of protein kinase activity; positive regulation of transcription factor activity; signal transduction; cell adhesion; regulation of bone mineralization Reference #:  Q16832 (UniProtKB) Alt. Names/Synonyms: CD167 antigen-like family member B; cell migration-inducing protein 20; DDR2; Discoidin domain receptor 2; discoidin domain receptor family, member 2; discoidin domain receptor tyrosine kinase 2; Discoidin domain-containing receptor 2; hydroxyaryl-protein kinase; MIG20a; migration-inducing gene 16 protein; neurotrophic tyrosine kinase receptor related 3; Neurotrophic tyrosine kinase, receptor-related 3; NTRKR3; Receptor protein-tyrosine kinase TKT; TKT; TYRO10; Tyrosine-protein kinase TYRO10; tyrosylprotein kinase Gene Symbols: DDR2 Molecular weight: 96,736 Da Basal Isoelectric point: 5.2  Predict pI for various phosphorylation states CST Pathways:  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below DDR2 2WUH - A=26-190 (human) 2Z4F - A=22-186 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2WUH 2Z4F  |  ENZYME 2.7.1.112 2.7.10.1  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
molecular association, regulation: Y471‑p phosphorylation: Y736‑p, Y740‑p, Y741‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		S37-p	CRYPLGMsGGQIPDE
0	2		S459-p	SMFNNNRsSsPSEQG
0	3		S461-p	FNNNRsSsPSEQGsN
0	1		S467-p	SsPSEQGsNSTyDRI
1	8		Y471-p	EQGsNSTyDRIFPLR
0	95		Y481-p	IFPLRPDyQEPsRLI
0	1		S485-p	RPDyQEPsRLIRKLP
0	1		S501	FAPGEEESGCSGVVK
0	5		Y521-p	GPEGVPHyAEADIVN
0	1		K608-a	QPVLVAVkMLRADAN
0	1		K616-a	MLRADANkNARNDFL
0	1		S675-p	RHEPPNSsSSDVRTV
0	1		K720-a	TRNCLVGkNYTIKIA
1	434		Y736-p	FGMSRNLysGDyyRI
0	11		S737-p	GMSRNLysGDyyRIQ
1	391		Y740-p	RNLysGDyyRIQGRA
1	23		Y741-p	NLysGDyyRIQGRAV
0	1		Y813-p	RDQGRQTyLPQPAIC

	DDR2 iso3
-	under review
S69	SMFNNNRSSSPSEQG
S71	FNNNRSSSPSEQGSN
S77	SSPSEQGSNSTYDRI
Y81	EQGSNSTYDRIFPLR
Y91	IFPLRPDYQEPSRLI
S95	RPDYQEPSRLIRKLP
S111-p	FAPGEEEsGEDDVVG
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

	mouse
S37	CRYPLGMSGGHIPDE
S459-p	SMFNNNRsSsPSEQE
S461-p	FNNNRsSsPSEQESN
S467	SsPSEQESNSTyDRI
Y471-p	EQESNSTyDRIFPLR
Y481-p	IFPLRPDyQEPSRLI
S485	RPDyQEPSRLIRKLP
S501	FAPGEEESGCSGVVK
Y521-p	GPEGVPHyAEADIVN
K608-a	QPVLVAVkMLRADAN
K616-a	MLRADANkNARNDFL
S674	SRHEPLSSCSSDATV
K719	TRNCLVGKNYTIKIA
Y735-p	FGMSRNLysGDyyRI
S736-p	GMSRNLysGDyyRIQ
Y739-p	RNLysGDyyRIQGRA
Y740-p	NLysGDyyRIQGRAV
Y812	RDQGRQIYLPQPALC

	rat
S37	CRYPLGMSGGHIPDE
S459	SMFNNNHSSSPSEQE
S461	FNNNHSSSPSEQESN
S467	SSPSEQESNSTYDRI
Y471	EQESNSTYDRIFPLR
Y481	IFPLRPDYQEPSRLI
S485	RPDYQEPSRLIRKLP
S501	FAPGEEESGCSGVVK
Y521	GPEGVPHYAEADIVN
K608	QPVLVAVKMLRADAN
K616	MLRADANKNARNDFL
S674	SRHEPLSSGSSNATV
K719	TRNCLVGKNYTIKIA
Y735-p	FGMSRNLySGDyYRI
S736	GMSRNLySGDyYRIQ
Y739-p	RNLySGDyYRIQGRA
Y740	NLySGDyYRIQGRAV
Y812	RDQGRQIYLPQPAVC

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