This tyrosine kinase receptor for fibrillar collagen mediates fibroblast migration and proliferation. Contributes to cutaneous wound healing. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor); Membrane protein, integral; EC 188.8.131.52; TK group; DDR family
Chromosomal Location of Human Ortholog: 1q23.3
Cellular Component: integral to plasma membrane; apical plasma membrane; plasma membrane
Molecular Function: collagen binding; protein binding; transmembrane receptor protein tyrosine kinase activity; ATP binding
Biological Process: positive regulation of osteoblast differentiation; extracellular matrix organization and biogenesis; positive regulation of fibroblast proliferation; ossification; peptidyl-tyrosine phosphorylation; collagen fibril organization; biomineral formation; positive regulation of protein kinase activity; protein amino acid autophosphorylation; positive regulation of transcription factor activity; signal transduction; cell adhesion; regulation of bone mineralization
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.