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Protein Page:
FOXA3 (human)

Overview
FOXA3 Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: transcription factor complex; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein domain specific binding; sequence-specific DNA binding; double-stranded DNA binding; transcription factor binding; DNA bending activity; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; tissue development; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; cellular response to starvation; pattern specification process; endocrine pancreas development; embryonic development; regulation of transcription factor activity; cell glucose homeostasis; neuron fate specification; spermatogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of neuron differentiation
Reference #:  P55318 (UniProtKB)
Alt. Names/Synonyms: FKHH3; Fork head-related protein FKH H3; forkhead box A3; Forkhead box protein A3; FOXA3; hepatocyte nuclear factor 3, gamma; Hepatocyte nuclear factor 3-gamma; HNF-3-gamma; HNF-3G; HNF3G; MGC10179; TCF-3G; TCF3G; Transcription factor 3G
Gene Symbols: FOXA3
Molecular weight: 37,140 Da
Basal Isoelectric point: 7.01  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Select Structure to View Below

FOXA3

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y109-p GKEMPKGyRRPLAHA
0 1 S170-p NSIRHSLsFNDCFVK
  mouse

 
Y111 GKEMAKGYRRPLAHA
S172-p NSIRHSLsFNDCFVK
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