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FOXA3 (human)

Overview FOXA3 Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis. Note: This description may include information from UniProtKB. Protein type: Transcription factor; DNA binding protein Cellular Component: transcription factor complex; nucleus Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein domain specific binding; sequence-specific DNA binding; double-stranded DNA binding; transcription factor activity; DNA bending activity; transcription factor binding Biological Process: negative regulation of cell proliferation; embryonic development; regulation of transcription factor activity; neural plate anterioposterior pattern formation; neuron fate specification; cell glucose homeostasis; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis; chromatin modification; brain development; cellular response to starvation; endocrine pancreas development Reference #:  P55318 (UniProtKB) Alt. Names/Synonyms: FKHH3; Fork head-related protein FKH H3; forkhead box A3; Forkhead box protein A3; FOXA3; hepatocyte nuclear factor 3, gamma; Hepatocyte nuclear factor 3-gamma; HNF-3-gamma; HNF-3G; HNF3G; MGC10179; TCF-3G; TCF3G; Transcription factor 3G Gene Symbols: FOXA3 Molecular weight: 37,140 Da Basal Isoelectric point: 7.01  Predict pI for various phosphorylation states CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling

Select Structure to View Below FOXA3 1VTN - C=115-215 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y109-p	GKEMPKGyRRPLAHA
0	1		S170-p	NSIRHSLsFNDCFVK
0	1		K214-a	LRRQKRFkLEEkVKk
0	1		K218-a	KRFkLEEkVKkGGSG
0	1		K221-a	kLEEkVKkGGSGAAT

	mouse
Y111	GKEMAKGYRRPLAHA
S172-p	NSIRHSLsFNDCFVK
K216-a	LRRQKRFkLEEkAKk
K220-a	KRFkLEEkAKkGNSA
K223-a	kLEEkAKkGNSATSA

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