Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein domain specific binding; sequence-specific DNA binding; double-stranded DNA binding; DNA bending activity; transcription factor activity; transcription factor binding
Biological Process: transcription from RNA polymerase II promoter; tissue development; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; cellular response to starvation; endocrine pancreas development; pattern specification process; regulation of transcription factor activity; cell glucose homeostasis; neuron fate specification; spermatogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of neuron differentiation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.