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Protein Page:
FOXA3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FOXA3 Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: nucleus
Molecular Function: protein domain specific binding; sequence-specific DNA binding; transcription factor binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; cell glucose homeostasis; spermatogenesis; positive regulation of transcription from RNA polymerase II promoter; chromatin modification; cell differentiation; cellular response to starvation; endocrine pancreas development
Reference #:  P55318 (UniProtKB)
Alt. Names/Synonyms: FKHH3; Fork head-related protein FKH H3; forkhead box A3; Forkhead box protein A3; FOXA3; hepatocyte nuclear factor 3, gamma; Hepatocyte nuclear factor 3-gamma; HNF-3-gamma; HNF-3G; HNF3G; MGC10179; TCF-3G; TCF3G; Transcription factor 3G
Gene Symbols: FOXA3
Molecular weight: 37,140 Da
Basal Isoelectric point: 7.01  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Select Structure to View Below

FOXA3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y109-p GKEMPKGyRRPLAHA
0 1 S170-p NSIRHSLsFNDCFVK
0 1 K214 LRRQKRFKLEEKVKK
0 1 K218 KRFKLEEKVKKGGSG
0 1 K221 KLEEKVKKGGSGAAT
  mouse

 
Y111 GKEMAKGYRRPLAHA
S172-p NSIRHSLsFNDCFVK
K216-ac LRRQKRFkLEEkAKk
K220-ac KRFkLEEkAKkGNSA
K223-ac kLEEkAKkGNSATSA
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