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Protein Page:
DDR1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DDR1 Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. Interacts (via PPxY motif) with WWC1 (via WW domains) in a collagen-regulated manner. Forms a tripartite complex with WWC1 and PRKCZ, but predominantly in the absence of collagen. Interacts (tyrosine phosphorylated) with SHC1. Interacts with SRC. Interacts with MYH9. Interacts with CDH1. Interacts with PTPN11. Interacts with NCK2. Detected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A-431 epidermoid carcinoma cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells. Expressed at low levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines. In the colonic mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the thyroid gland, expressed in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of Langerhans cells, but not in the surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in the epithelia of the distal tubules. Not expressed in connective tissue, endothelial cells, adipose tissue, muscle cells or cells of hematopoietic origin. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; EC 2.7.10.1; Membrane protein, integral; EC 2.7.1.112; Protein kinase, tyrosine (receptor); Protein kinase, TK; TK group; DDR family
Cellular Component: extracellular space; integral to plasma membrane; plasma membrane; receptor complex
Molecular Function: collagen binding; protein binding; metal ion binding; transmembrane receptor protein tyrosine kinase activity; ATP binding
Biological Process: lactation; negative regulation of cell proliferation; extracellular matrix organization and biogenesis; regulation of cell-matrix adhesion; protein amino acid autophosphorylation; smooth muscle cell migration; ear development; regulation of cell growth; cell adhesion; embryo implantation
Reference #:  Q08345 (UniProtKB)
Alt. Names/Synonyms: CAK; CD167; CD167 antigen-like family member A; Cell adhesion kinase; DDR; DDR1; discoidin domain receptor family, member 1; discoidin domain receptor tyrosine kinase 1; Discoidin receptor tyrosine kinase; EDDR1; Epithelial discoidin domain receptor 1; Epithelial discoidin domain-containing receptor 1; HGK2; mammarian carcinoma kinase 10; Mammary carcinoma kinase 10; MCK-10; MCK10; NEP; neuroepithelial tyrosine kinase; neurotrophic tyrosine kinase, receptor, type 4; NTRK4; Protein-tyrosine kinase 3A; Protein-tyrosine kinase RTK-6; PTK3; PTK3A; PTK3A protein tyrosine kinase 3A; RTK6; TRK E; TRKE; Tyrosine kinase DDR; Tyrosine-protein kinase CAK
Gene Symbols: DDR1
Molecular weight: 101,128 Da
Basal Isoelectric point: 6.38  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DDR1

Protein Structure Not Found.


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Sites Implicated In
activity, induced: Y484‑p, Y513‑p, Y520‑p, Y792‑p, Y796‑p, Y797‑p
molecular association, regulation: Y513‑p, Y703‑p, Y740‑p, Y796‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S45-p QDRTIPDsDISASSS
0 1 K112-ub RHAGGLGkEFSRSYR
0 1 K153-ub DPEGVVLkDLGPPMV
0 7 K449-ub HWRRLLSkAERRVLE
0 4 T469-p HLSVPGDtILINNRP
0 38 Y484-p GPREPPPyQEPRPRG
0 2 S496-p PRGNPPHsAPCVPNG
2 338 Y513-p LLLSNPAyRLLLAty
0 7 T519-p AyRLLLAtyARPPRG
0 88 Y520-p yRLLLAtyARPPRGP
0 1 K613-m1 PRSRLRFkEkLGEGQ
0 1 K615-m1 SRLRFkEkLGEGQFG
0 1 S631-p VHLCEVDsPQDLVSL
0 1 K663 ILRPDATKNARNDFL
1 0 Y703-p PLCMITDyMENGDLN
1 0 Y740-p AQGPTISyPMLLHVA
1 0 S788-p KIADFGMsRNLyAGD
0 931 Y792-p FGMsRNLyAGDyyRV
1 941 Y796-p RNLyAGDyyRVQGRA
0 305 Y797-p NLyAGDyyRVQGRAV
0 1 Y869-p RDQGRQVyLSRPPAC
0 1 Y881-p PACPQGLyELMLRCW
11994 : Phospho-DDR1 (Tyr792) Antibody
  mouse

 
S46 QDRTIPDSDISVSSS
K113 RHAGGLGKEFSRSYR
K154 DPGGVVLKDLGPPMV
K447-ub HWRRLLSkAERRVLE
T467 HLSVPGDTILINNRP
Y482 GPREPPPYQEPRPRG
S494 PRGTPPHSAPCVPNG
Y511-p LLLSNPAyRLLLATY
T517 AyRLLLATYARPPRG
Y518 yRLLLATYARPPRGP
K611 PRSRLRFKEKLGEGQ
K613 SRLRFKEKLGEGQFG
D629 VHLCEVEDPQDLVSS
K661-ub ILRPDATkNARNDFL
Y701 PLCMITDYMENGDLN
Y738 DQGPTISYPMLLHVG
S786 KIADFGMSRNLyAGD
Y790-p FGMSRNLyAGDyyRV
Y794-p RNLyAGDyyRVQGRA
Y795-p NLyAGDyyRVQGRAV
Y867 RDQGRQVYLSRPPAC
Y879 PACPQTLYELMLRCW
11994 : Phospho-DDR1 (Tyr792) Antibody
  rat

 
S46 QDRTIPDSDISVSSS
K113 RHAGGLGKEFSRSYR
K154 DPGGVVLKDLGPPMV
K446-ub HWRRLLSkAERRVLE
T466 HLSVPGDTILINNRP
Y481 GPREPPPYQEPRPRG
S493 PRGTPTHSAPCVPNG
Y510 LLLSNPAYRLLLATy
T516 AYRLLLATyARPPRG
Y517-p YRLLLATyARPPRGP
K610 PRSRLRFKEKLGEGQ
K612 SRLRFKEKLGEGQFG
D628 VHLCEVEDPQDLVTS
K660 ILRPDATKNARNDFL
Y700 PLCMITDYMENGDLN
Y737 DQGPTISYPMLLHVG
S785 KIADFGMSRNLyAGD
Y789-p FGMSRNLyAGDyYRV
Y793-p RNLyAGDyYRVQGRA
Y794 NLyAGDyYRVQGRAV
Y866 RDQGRQVYLSRPPAC
Y878 PACPQTLYELMLRCW
11994 : Phospho-DDR1 (Tyr792) Antibody
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