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CYP19A1 (human)

Overview CYP19A1 Catalyzes the formation of aromatic C18 estrogens from C19 androgens. Belongs to the cytochrome P450 family. Note: This description may include information from UniProtKB. Protein type: Lipid Metabolism - androgen and estrogen; Oxidoreductase; EC 1.14.14.1 Cellular Component: synaptic vesicle; endoplasmic reticulum membrane; membrane; cell soma; endoplasmic reticulum; dendritic spine; terminal button; cytosol Molecular Function: electron carrier activity; iron ion binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; oxygen binding Biological Process: steroid metabolic process; response to drug; hypothalamus development; granulocyte differentiation; response to cesium; bile acid metabolic process; adrenal gland development; dibenzo-p-dioxin metabolic process; androgen metabolic process; hippocampus development; male gonad development; phthalate metabolic process; response to morphine; response to herbicide; response to testosterone stimulus; progesterone metabolic process; estrogen biosynthetic process; response to estradiol stimulus; biphenyl metabolic process; xenobiotic metabolic process; melatonin metabolic process; regulation of synapse structure and activity; response to ionizing radiation; steroid biosynthetic process Reference #:  P11511 (UniProtKB) Alt. Names/Synonyms: ARO; ARO1; Aromatase; CP19A; CPV1; CYAR; CYP19; CYP19A1; CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; cytochrome P450, family 19, subfamily A, polypeptide 1; cytochrome P450, subfamily XIX (aromatization of androgens); Estrogen synthase; estrogen synthetase; flavoprotein-linked monooxygenase; MGC104309; microsomal monooxygenase; P-450AROM Gene Symbols: CYP19A1 Molecular weight: 57,883 Da Basal Isoelectric point: 7.2  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CYP19A1 1TQA - A=53-495 (human) 3EQM - A=1-503 (human) 3S79 - A=1-503 (human) 3S7S - A=1-503 (human) 4GL5 - A=1-503 (human) 4GL7 - A=1-503 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1TQA 3EQM 3S79 3S7S 4GL5 4GL7  |  ENZYME  |  Phospho3D  |  DISEASE 107910 139300  |  InnateDB  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, induced: Y361‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y112-p	HIMKHNHySSRFGSK
1	0		S118	HySSRFGSKLGLQCI
0	1		T162-p	PGLVRMVtVCAESLK
0	1		T201-p	VMLDTSNtLFLRIPL
0	1		Y241-p	FFKISWLyKKYEKSV
1	0		Y361-p	KVMENFIyESMRYQP
0	3		T392-p	GYPVKKGtNIILNIG
0	1		Y441-p	PRGCAGKyIAMVMMK
0	1		T484-p	LSLHPDEtKNMLEMI
0	1		S497-p	MIFTPRNsDRCLEH_

	mouse
Y112	HVMKHSHYISRFGsK
S118-p	HYISRFGsKRGLQCI
E162	PGLVRMVEVCVESIK
M201	IMLDTSNMLFLGIPL
Y241	FFKISWLYRKYERSV
N361	KVVENFINESMRYQP
T392-p	GYPVKKGtNIILNIG
Y441	PRGCAGKYIAMVMMK
D484	LSLHPNEDRHLVEII
S497	IIFSPRNSDKYLQQ_

	rat
Y112	HVMKHSNYISRFGSK
S118	NYISRFGSKRGLQCI
E162	PGLIRMVEVCVESIK
T201	IMLDTSNTLFLGIPL
Y241	FFKISWLYRKYERSV
N361	KVVENFINESLRYQP
T392	GYPVKKGTNIILNIG
Y441	PRSCAGKYIAMVMMK
D484	LSLHLDEDSPIVEII
N497	IIFRHIFNTPFLQCL

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