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RUNX1T1 (human)

Overview RUNX1T1 Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress transactivation mediated by TCF12. Homotetramer. Heterotetramer with CBFA2T2 and CBFA2T3. Interacts with TCF12, SIN3A, HDAC1, HDAC2, HDAC3, NCOR1 and NCOR2. Interacts with ATN1 (via its N-terminus); the interaction enhances the transcriptional repression. Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary. Belongs to the CBFA2T family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Cellular Component: nuclear matrix Molecular Function: identical protein binding; protein binding; DNA binding; zinc ion binding; transcription factor activity Biological Process: generation of precursor metabolites and energy; transcription, DNA-dependent Reference #:  Q06455 (UniProtKB) Alt. Names/Synonyms: acute myelogenous leukemia 1 translocation 1, cyclin-D related; AML1T1; CBFA2T1; CDR; core-binding factor, runt domain, alpha subunit 2; cyclin D-related; Cyclin-D-related protein; Eight twenty one protein; ETO; MGC2796; MTG8; MTG8b; myeloid translocation gene on 8q22; Protein CBFA2T1; Protein ETO; Protein MTG8; runt-related transcription factor 1; RUNX1T1; translocated to, 1; translocated to, 1 (cyclin D-related); Zinc finger MYND domain-containing protein 2; ZMYND2 Gene Symbols: RUNX1T1 Molecular weight: 67,566 Da Basal Isoelectric point: 8.15  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below RUNX1T1 1WQ6 - A/B=335-403 (human) 2DJ8 - A=449-450 (human) 2H7B - A=120-222 (human) 2KNH - A=119-216 (human) 2KYG - C=437-467 (human) 2OD1 - A=510-559 (human) 2ODD - A=508-559 (human) 2PP4 - A=119-225 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1WQ6 2DJ8 2H7B 2KNH 2KYG 2OD1 2ODD 2PP4  |  Phospho3D  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		-	gap
0	1		-	gap
0	1		T32	FEYCQDRTEKHSTMP
0	1		S41-p	KHSTMPDsPVDVKtQ
0	2		T47-p	DsPVDVKtQSRLtPP
0	1		S49	PVDVKtQSRLtPPtM
0	1		T52-p	VKtQSRLtPPtMPPP
0	1		T55-p	QSRLtPPtMPPPPTT
0	1		Y315-p	AHHYRDSyRHPSHRD
0	3		S417-p	SSHSRQQsPVNPDPV
0	2		S590-p	PPAATPRsttPGtPS
0	2		T591-p	PAATPRsttPGtPST
0	2		T592-p	AATPRsttPGtPSTI
0	4		T595-p	PRsttPGtPSTIETT
0	1		S597	sttPGtPSTIETTPR

	RUNX1T1 iso4
-	gap
S5-p	___MVGLsGPVQYRT
T12	sGPVQYRTEKHSTMP
S21	KHSTMPDSPVDVKTQ
T27	DSPVDVKTQSRLTPP
S29	PVDVKTQSRLTPPTM
T32	VKTQSRLTPPTMPPP
T35	QSRLTPPTMPPPPTT
Y295	AHHYRDSYRHPSHRD
S397	SSHSRQQSPVNPDPV
S570	PPAATPRSTTPGTPS
T571	PAATPRSTTPGTPST
T572	AATPRSTTPGTPSTI
T575	PRSTTPGTPSTIETT
S577	STTPGTPSTIETTPR

	RUNX1T1 iso6
S77-p	TPGLDAIsHHLCYPD
-	gap
T91	DRTHRDRTEKHSTMP
S100	KHSTMPDSPVDVKTQ
T106	DSPVDVKTQSRLTPP
S108	PVDVKTQSRLTPPTM
T111	VKTQSRLTPPTMPPP
T114	QSRLTPPTMPPPPTT
Y374	AHHYRDSYRHPSHRD
S476	SSHSRQQSPVNPDPV
S649	PPAATPRSTTPGTPS
T650	PAATPRSTTPGTPST
T651	AATPRSTTPGTPSTI
T654	PRSTTPGTPSTIETT
S656	STTPGTPSTIETTPR

	mouse
-	gap
-	gap
T5-p	___MPDRtEKHSTMP
S14	KHSTMPDSPVDVKtQ
T20-p	DSPVDVKtQsRLTPP
S22-p	PVDVKtQsRLTPPAM
T25	VKtQsRLTPPAMPPP
A28	QsRLTPPAMPPPPTT
Y288	AHHYRDSYRHPSHRD
S390-p	SSHSRQQsPVNPDPV
S563	PPAATPRSTtPGtPs
T564	PAATPRSTtPGtPsT
T565-p	AATPRSTtPGtPsTI
T568-p	PRSTtPGtPsTIETT
S570-p	STtPGtPsTIETTPR

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