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Protein Page:
RUNX1T1 (human)

Overview
RUNX1T1 Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress transactivation mediated by TCF12. Homotetramer. Heterotetramer with CBFA2T2 and CBFA2T3. Interacts with TCF12, SIN3A, HDAC1, HDAC2, HDAC3, NCOR1 and NCOR2. Interacts with ATN1 (via its N-terminus); the interaction enhances the transcriptional repression. Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary. Belongs to the CBFA2T family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: nuclear matrix
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; DNA binding; metal ion binding; transcription factor activity
Biological Process: fat cell differentiation; generation of precursor metabolites and energy; regulation of transcription, DNA-dependent; transcription, DNA-dependent; regulation of DNA binding
Reference #:  Q06455 (UniProtKB)
Alt. Names/Synonyms: acute myelogenous leukemia 1 translocation 1, cyclin-D related; AML1T1; CBFA2T1; CDR; core-binding factor, runt domain, alpha subunit 2; cyclin D-related; Cyclin-D-related protein; Eight twenty one protein; ETO; MGC2796; MTG8; MTG8b; myeloid translocation gene on 8q22; Protein CBFA2T1; Protein ETO; Protein MTG8; runt-related transcription factor 1; RUNX1T1; translocated to, 1; translocated to, 1 (cyclin D-related); Zinc finger MYND domain-containing protein 2; ZMYND2
Gene Symbols: RUNX1T1
Molecular weight: 67,566 Da
Basal Isoelectric point: 8.15  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RUNX1T1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T32 FEYCQDRTEKHSTMP
0 1 S41-p KHSTMPDsPVDVKtQ
0 2 T47-p DsPVDVKtQsRLtPP
0 1 S49-p PVDVKtQsRLtPPtM
0 1 T52-p VKtQsRLtPPtMPPP
0 1 T55-p QsRLtPPtMPPPPTT
0 1 Y315-p AHHYRDSyRHPSHRD
0 4 S417-p SSHSRQQsPVNPDPV
0 1 T462-p EVKRQAMtELQKAVS
0 2 S590-p PPAATPRsttPGtPs
0 2 T591-p PAATPRsttPGtPsT
0 4 T592-p AATPRsttPGtPsTI
0 5 T595-p PRsttPGtPsTIETT
0 1 S597-p sttPGtPsTIETTPR
  mouse

 
T5-p ___MPDRtEKHSTMP
S14 KHSTMPDSPVDVKtQ
T20-p DSPVDVKtQsRLTPP
S22-p PVDVKtQsRLTPPAM
T25 VKtQsRLTPPAMPPP
A28 QsRLTPPAMPPPPTT
Y288 AHHYRDSYRHPSHRD
S390-p SSHSRQQsPVNPDPV
T435 EVKRQAMTELQKAVS
S563 PPAATPRSTtPGtPs
T564 PAATPRSTtPGtPsT
T565-p AATPRSTtPGtPsTI
T568-p PRSTtPGtPsTIETT
S570-p STtPGtPsTIETTPR
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