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Protein Page:
CCK4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CCK4 Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, tyrosine (receptor); Protein kinase, TK; EC 2.7.10.1; Membrane protein, integral; Kinase, protein; TK group; CCK4 family
Cellular Component: integral to plasma membrane; intercellular junction
Molecular Function: protein binding; transmembrane receptor protein tyrosine kinase activity; ATP binding
Biological Process: cell migration; peptidyl-tyrosine phosphorylation; wound healing; convergent extension; neural tube closure; actin cytoskeleton reorganization; establishment of epithelial cell polarity; establishment of planar polarity; Wnt receptor signaling pathway through beta-catenin; signal transduction; cell adhesion
Reference #:  Q13308 (UniProtKB)
Alt. Names/Synonyms: CCK-4; CCK4; Colon carcinoma kinase 4; colon carcinoma kinase-4; Protein-tyrosine kinase 7; PTK7; PTK7 protein tyrosine kinase 7; Tyrosine-protein kinase-like 7
Gene Symbols: PTK7
Molecular weight: 118,392 Da
Basal Isoelectric point: 6.67  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CCK4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S39-p IVFIKQPssQDALQG
0 1 S40-p VFIKQPssQDALQGR
0 1 S96 AVDRLQDSGTFQCVA
0 1 K132-ub EAGPVVLkHPASEAE
0 1 K181-ub SNHTVSSkERNLTLR
0 1 T279-p PPHLRRAtVFANGsL
0 1 S285-p AtVFANGsLLLTQVR
0 1 S542-p KWERADGssLPEWVT
0 1 S543-p WERADGssLPEWVTD
0 1 T561-p TLHFARVtRDDAGNY
0 1 K636-ub DRILDPTkLGPRMHI
0 8 S784-p AATNKRHstsDKMHF
0 5 T785-p ATNKRHstsDKMHFP
0 1 S786-p TNKRHstsDKMHFPR
0 1 K804-ub QPITTLGkSEFGEVF
0 1 K835-ub LVKSLQSkDEQQQLD
0 1 Y872-p CREAEPHyMVLEYVD
0 1 K898-ub KSKDEKLkSQPLSTK
0 1 Y960-p KDVYNSEyYHFRQAW
0 1 S1064 IASALGDSTVDSkP_
0 1 K1069-ub GDSTVDSkP______
  mouse

 
S31 IVFIKEPSSQDALQG
S32 VFIKEPSSQDALQGR
S88-p AVDRLQDsGAFQCVA
K124 EAGPVVLKHPASEAE
R173 STHTVSSRERNLTLR
V271 PPHLRRAVVFANGSL
S277 AVVFANGSLLLTQVR
S534 KWVRADGSSLPEWVT
S535 WVRADGSSLPEWVTD
T553 TLHFARVTRDDAGNY
K628 DRILDPTKLGPRMHI
S776 PATNKRHSAGDRMHF
A777 ATNKRHSAGDRMHFP
G778 TNKRHSAGDRMHFPR
K796 QPITTLGKSEFGEVF
R827 LVKSLQSRDEQQQLD
Y864 CREAEPHYMVLEYVD
K890 KNKDEKLKSQPLSTK
Y952 KDVYNSEYYHFRQAW
S1056-p IASTLGDsPADSKQ_
K1061 GDsPADSKQ______
  rat

 
- gap
- gap
- gap
R20 TSLWQGMRRPCSIAS
- gap
- gap
S58 AMVFANGSLLLTQVR
S315 KWVRADGSSLPEWVT
S316 WVRADGSSLPEWVTD
T334 TLHFARVTRDDAGNY
K409 DRILDPTKLGPRMHI
S489 TATNKRHSTGDKMHF
T490 ATNKRHSTGDKMHFP
G491 TNKRHSTGDKMHFPR
K509 QPITTLGKSEFGEVF
K540 LVKSLQNKDEQQQLD
Y577 CREAEPHYMVLEYVD
K603 KNKDEKLKSQPLSTK
Y665 KDVYNSEYYHFRQAW
G769 IASTLGDGPADSKQ_
K774 GDGPADSKQ______
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