Home

CCK4 (human)

Overview CCK4 Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; CCK4 family Cellular Component: integral to plasma membrane; intercellular junction Molecular Function: protein binding; transmembrane receptor protein tyrosine kinase activity; ATP binding Biological Process: cell migration; wound healing; convergent extension; actin cytoskeleton reorganization; neural tube closure; establishment of epithelial cell polarity; establishment of planar polarity; Wnt receptor signaling pathway through beta-catenin; cell adhesion; signal transduction Reference #:  Q13308 (UniProtKB) Alt. Names/Synonyms: CCK-4; CCK4; Colon carcinoma kinase 4; colon carcinoma kinase-4; Protein-tyrosine kinase 7; PTK7; PTK7 protein tyrosine kinase 7; Tyrosine-protein kinase-like 7 Gene Symbols: PTK7 Molecular weight: 118,392 Da Basal Isoelectric point: 6.67  Predict pI for various phosphorylation states CST Pathways:  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CCK4

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S39-p	IVFIKQPssQDALQG
0	1		S40-p	VFIKQPssQDALQGR
0	1		S96	AVDRLQDSGTFQCVA
0	1		K132-u	EAGPVVLkHPASEAE
0	1		K181-u	SNHTVSSkERNLTLR
0	1		T279-p	PPHLRRAtVFANGsL
0	1		S285-p	AtVFANGsLLLTQVR
0	1		S542-p	KWERADGssLPEWVT
0	1		S543-p	WERADGssLPEWVTD
0	1		T561-p	TLHFARVtRDDAGNY
0	1		K636-u	DRILDPTkLGPRMHI
0	8		S784-p	AATNKRHstsDKMHF
0	5		T785-p	ATNKRHstsDKMHFP
0	1		S786-p	TNKRHstsDKMHFPR
0	1		K804-u	QPITTLGkSEFGEVF
0	1		K835-u	LVKSLQSkDEQQQLD
0	1		Y872-p	CREAEPHyMVLEYVD
0	1		K898-u	KSKDEKLkSQPLSTK
0	1		Y960-p	KDVYNSEyYHFRQAW
0	1		S1064	IASALGDSTVDSkP_
0	1		K1069-u	GDSTVDSkP______

	mouse
S31	IVFIKEPSSQDALQG
S32	VFIKEPSSQDALQGR
S88-p	AVDRLQDsGAFQCVA
K124	EAGPVVLKHPASEAE
R173	STHTVSSRERNLTLR
V271	PPHLRRAVVFANGSL
S277	AVVFANGSLLLTQVR
S534	KWVRADGSSLPEWVT
S535	WVRADGSSLPEWVTD
T553	TLHFARVTRDDAGNY
K628	DRILDPTKLGPRMHI
S776	PATNKRHSAGDRMHF
A777	ATNKRHSAGDRMHFP
G778	TNKRHSAGDRMHFPR
K796	QPITTLGKSEFGEVF
R827	LVKSLQSRDEQQQLD
Y864	CREAEPHYMVLEYVD
K890	KNKDEKLKSQPLSTK
Y952	KDVYNSEYYHFRQAW
S1056-p	IASTLGDsPADSKQ_
K1061	GDsPADSKQ______

	rat
-	gap
-	gap
-	gap
R20	TSLWQGMRRPCSIAS
-	gap
-	gap
S58	AMVFANGSLLLTQVR
S315	KWVRADGSSLPEWVT
S316	WVRADGSSLPEWVTD
T334	TLHFARVTRDDAGNY
K409	DRILDPTKLGPRMHI
S489	TATNKRHSTGDKMHF
T490	ATNKRHSTGDKMHFP
G491	TNKRHSTGDKMHFPR
K509	QPITTLGKSEFGEVF
K540	LVKSLQNKDEQQQLD
Y577	CREAEPHYMVLEYVD
K603	KNKDEKLKSQPLSTK
Y665	KDVYNSEYYHFRQAW
G769	IASTLGDGPADSKQ_
K774	GDGPADSKQ______

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.