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Protein Page:
ALAS1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ALAS1 the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]
Protein type: Mitochondrial; Transferase; EC 2.3.1.37; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Amino Acid Metabolism - glycine, serine and threonine
Cellular Component: mitochondrion; mitochondrial matrix; cytoplasm; nucleolus; nucleus
Molecular Function: 5-aminolevulinate synthase activity; pyridoxal phosphate binding
Biological Process: porphyrin metabolic process; cellular lipid metabolic process; protoporphyrinogen IX biosynthetic process; heme biosynthetic process
Reference #:  P13196 (UniProtKB)
Alt. Names/Synonyms: 5-aminolevulinate synthase, nonspecific, mitochondrial; 5-aminolevulinic acid synthase 1; ALAS; ALAS-H; ALAS1; ALAS3; ALASH; aminolevulinate, delta-, synthase 1; Delta-ALA synthase 1; Delta-aminolevulinate synthase 1; HEM1; MIG4; migration-inducing protein 4
Gene Symbols: ALAS1
Molecular weight: 70,581 Da
Basal Isoelectric point: 8.74  Predict pI for various phosphorylation states
Select Structure to View Below

ALAS1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K21 VPQAFLQKAGKSLLF
0 3 S127 SSVFCKASLELQEDV
0 1 K157-ub GPSVVSVkTDGGDPS
0 2 K168-ub GDPSGLLkNFQDIMQ
0 1 K176-ac NFQDIMQkQRPERVS
0 1 Y216-p EKKNDHTyRVFKTVN
0 1 K242-ub YSDSLITkKQVSVWC
0 1 T280-p HGAGAGGtRNIsGTs
0 1 S284-p AGGtRNIsGTsKFHV
0 1 S287-p tRNIsGTsKFHVDLE
0 1 K435 DRDGVMPKMDIISGT
0 1 K539 VRVADAAKNTEVCDE
0 1 Y628-p MSEREKSyFSGLSKL
  mouse

 
K21-ub VPQAFLQkAGKSLLF
S129-p SSVFRKAsLELQEDV
K159 PPSLVNVKTDGEDPS
K170-ub EDPSRLLkNFQDIMR
K178 NFQDIMRKQRPERVS
Y218 EKKNDHTYRVFKTVN
K244 YTDSLITKKQVSVWC
T282 HGAGAGGTRNISGTS
S286 AGGTRNISGTSKFHV
S289 TRNISGTSKFHVELE
K437-ub DRDGVMPkMDIISGT
K541-ub VRVADAAkNTEICDE
Y630 MSEREKAYFSGMSKM
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