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Protein Page:
ANGPT2 (human)

Overview
ANGPT2 Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Interacts with TEK/TIE2, competing for the same binding site as ANGPT1. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Cellular Component: extracellular space; cell projection; plasma membrane; extracellular region; nucleus
Molecular Function: protein binding; metal ion binding; receptor tyrosine kinase binding; receptor binding
Biological Process: Tie receptor signaling pathway; organ regeneration; maternal process involved in pregnancy; signal transduction; negative regulation of blood vessel endothelial cell migration; response to organic cyclic substance; germ cell development; negative regulation of positive chemotaxis; response to radiation; negative regulation of angiogenesis; positive regulation of angiogenesis; response to mechanical stimulus; response to hypoxia; response to glucose stimulus; angiogenesis; response to activity; blood coagulation; leukocyte migration
Reference #:  O15123 (UniProtKB)
Alt. Names/Synonyms: AGPT2; ANG-2; ANG2; angiopoietin 2; Angiopoietin-2; angiopoietin-2a; angiopoietin-2B; ANGP2; ANGPT2; Tie2-ligand
Gene Symbols: ANGPT2
Molecular weight: 56,919 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
Select Structure to View Below

ANGPT2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S225 VLVSKQNSIIEELEK
0 1 S242-p VTATVNNsVLQKQQH
0 2 Y482-p YYWKGSGySLKATTM
  mouse

 
S225-p VLVSKQSsVIDELEK
S242 VTATVNNSLLQKQQH
Y482 YYWKGSGYSLKATTM
  rat

 
S225 VLVSKQSSVIDELEK
S242 VTATVNNSVLQKQQH
Y482 YYWKGSGYSLKATTM
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