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ANGPT2 (human)

Overview ANGPT2 Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Interacts with TEK/TIE2, competing for the same binding site as ANGPT1. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Secreted; Secreted, signal peptide Cellular Component: extracellular space; cell projection; extracellular region; plasma membrane; nucleus Molecular Function: protein binding; metal ion binding; receptor tyrosine kinase binding; receptor binding Biological Process: organ regeneration; Tie receptor signaling pathway; maternal process involved in pregnancy; negative regulation of blood vessel endothelial cell migration; signal transduction; response to organic cyclic substance; germ cell development; negative regulation of positive chemotaxis; positive regulation of angiogenesis; response to radiation; negative regulation of angiogenesis; response to mechanical stimulus; response to hypoxia; response to glucose stimulus; angiogenesis; response to activity; blood coagulation; leukocyte migration Reference #:  O15123 (UniProtKB) Alt. Names/Synonyms: AGPT2; ANG-2; ANG2; angiopoietin 2; Angiopoietin-2; angiopoietin-2a; angiopoietin-2B; ANGP2; ANGPT2; Tie2-ligand Gene Symbols: ANGPT2 Molecular weight: 56,919 Da Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states

Select Structure to View Below ANGPT2 1Z3S - A/B=281-496 (human) 1Z3U - A/B/C/D=280-496 (human) 2GY7 - A=281-495 (human) 4JZC - A=279-496 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1Z3S 1Z3U 2GY7 4JZC  |  Phospho3D  |  DISEASE  |  InnateDB  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S225	VLVSKQNSIIEELEK
0	3		Y482-p	YYWKGSGySLKATTM

	mouse
S225-p	VLVSKQSsVIDELEK
Y482	YYWKGSGYSLKATTM

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