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Protein Page:
ADH1C (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ADH1C class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. [provided by RefSeq, Jul 2008]
Protein type: Xenobiotic Metabolism - metabolism by cytochrome P450; Cofactor and Vitamin Metabolism - retinol; Lipid Metabolism - fatty acid; Mitochondrial; EC 1.1.1.1; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Amino Acid Metabolism - tyrosine; Oxidoreductase
Cellular Component: cytosol
Molecular Function: zinc ion binding; alcohol dehydrogenase activity
Biological Process: xenobiotic metabolic process; ethanol oxidation
Reference #:  P00326 (UniProtKB)
Alt. Names/Synonyms: ADH, gamma subunit; ADH1C; ADH1G; ADH3; Alcohol dehydrogenase 1C; alcohol dehydrogenase 1C (class I), gamma polypeptide; alcohol dehydrogenase 3 (class I), gamma polypeptide; Alcohol dehydrogenase subunit gamma
Gene Symbols: ADH1C
Molecular weight: 39,868 Da
Basal Isoelectric point: 8.63  Predict pI for various phosphorylation states
Select Structure to View Below

ADH1C

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K6 __MSTAGKVIKCKAA
0 3 K9 STAGKVIKCKAAVLW
0 1 K9 STAGKVIKCKAAVLW
0 1 K11 AGKVIKCKAAVLWEL
0 1 K20 AVLWELKKPFSIEEV
0 1 K20 AVLWELKKPFSIEEV
0 2 K33 EVEVAPPKAHEVRIK
0 1 K33 EVEVAPPKAHEVRIK
0 2 K40 KAHEVRIKMVAAGIC
0 1 S49-p VAAGICRsDEHVVsG
0 1 S55-p RsDEHVVsGNLVTPL
0 1 K85 GEGVTTVKPGDKVIP
0 1 K89 TTVKPGDKVIPLFTP
0 1 K100-ac LFTPQCGkCRICKNP
0 2 K105 CGkCRICKNPESNYC
0 1 K105 CGkCRICKNPESNYC
0 1 K136 RRFTCSGKPIHHFVG
0 190 Y150-p GVSTFSQyTVVDENA
0 2 K169 DAASPLEKVCLIGCG
0 1 K169 DAASPLEKVCLIGCG
0 1 Y181-p GCGFSTGyGSAVKVA
0 2 K186 TGyGSAVKVAKVTPG
0 1 K227 IIAVDINKDKFAKAK
0 1 K227 IIAVDINKDKFAKAK
0 1 K227 IIAVDINKDKFAKAK
0 1 K229 AVDINKDKFAKAKEL
0 1 K234 KDKFAKAKELGATEC
0 3 K316 LLTGRTWKGAIFGGF
0 1 K316 LLTGRTWKGAIFGGF
0 1 K324 GAIFGGFKSKESVPK
0 1 K324 GAIFGGFKSKESVPK
0 2 K326 IFGGFKSKESVPKLV
0 2 K331 KSKESVPKLVADFMA
0 1 K331 KSKESVPKLVADFMA
0 16 K339-ac LVADFMAkKFSLDAL
0 1 K339 LVADFMAKKFSLDAL
0 1 K339 LVADFMAKKFSLDAL
0 2 K340 VADFMAkKFSLDALI
0 1 K340 VADFMAkKFSLDALI
0 2 K355 TNILPFEKINEGFDL
  mouse

 
K6-ub __MSTAGkVIkCkAA
K9-ac STAGkVIkCkAAVLW
K9-ub STAGkVIkCkAAVLW
K11-ub AGkVIkCkAAVLWEL
K20-ac AVLWELHkPFTIEDI
K20-ub AVLWELHkPFTIEDI
K33-ac DIEVAPPkAHEVRIk
K33-ub DIEVAPPkAHEVRIk
K40-ub kAHEVRIkMVATGVC
S49 VATGVCRSDDHVVSG
S55 RSDDHVVSGTLVTPL
K85-ub GEGVTCVkPGDkVIP
K89-ub TCVkPGDkVIPLFSP
E100 LFSPQCGECRICkHP
K105-ub CGECRICkHPESNFC
K105-ac CGECRICkHPESNFC
K136-ub SRFSCKGkQIHNFIS
Y150-p STSTFSQyTVVDDIA
K169-ub DGASPLDkVCLIGCG
K169-ac DGASPLDkVCLIGCG
Y181 GCGFSTGYGSAVkVA
K186-ub TGYGSAVkVAKVTPG
K227-ac IIAVDINkDkFAKAk
K227-ub IIAVDINkDkFAKAk
K227-sc IIAVDINkDkFAKAk
K229-ub AVDINkDkFAKAkEL
K234-ub kDkFAKAkELGATEC
K316-ub LLLGRTWkGAIFGGF
K316-sc LLLGRTWkGAIFGGF
K324-ub GAIFGGFkSkDSVPk
K324-sc GAIFGGFkSkDSVPk
K326-ac IFGGFkSkDSVPkLV
K331-ac kSkDSVPkLVADFMA
K331-ub kSkDSVPkLVADFMA
K339-ac LVADFMAkkFPLDPL
K339-ub LVADFMAkkFPLDPL
K339-sc LVADFMAkkFPLDPL
K340-ac VADFMAkkFPLDPLI
K340-ub VADFMAkkFPLDPLI
K355-ac THVLPFEkINEAFDL
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