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Protein Page:
Mer (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Mer a proto-oncogene receptor tyrosine-protein kinase of the Axl family. Binds several ligands including LGALS3, Tubby, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Interacts (upon activation) with TNK2; stimulates TNK2 autophosphorylation. Interacts with VAV1 in a phosphotyrosine-independent manner. Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver. Defects are a cause of retinitis pigmentosa, a group of human diseases that leads to degeneration of retinal photoreceptor cells. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, tyrosine (receptor); Protein kinase, TK; Membrane protein, integral; EC 2.7.10.1; Kinase, protein; TK group; Axl family
Cellular Component: extracellular space; photoreceptor outer segment; integral to plasma membrane; cytoplasm; plasma membrane
Molecular Function: protein binding; transmembrane receptor protein tyrosine kinase activity; ATP binding
Biological Process: negative regulation of lymphocyte activation; platelet activation; peptidyl-tyrosine phosphorylation; vagina development; protein amino acid phosphorylation; phagocytosis; cell surface receptor linked signal transduction; cell-cell signaling; retina development in camera-type eye; natural killer cell differentiation; positive regulation of phagocytosis; protein kinase B signaling cascade; spermatogenesis; blood coagulation; leukocyte migration; apoptotic cell clearance; secretion by cell
Reference #:  Q12866 (UniProtKB)
Alt. Names/Synonyms: c-mer; c-mer proto-oncogene tyrosine kinase; MER; MER receptor tyrosine kinase; MERTK; MGC133349; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK; RP38; STK kinase; Tyrosine-protein kinase Mer
Gene Symbols: MERTK
Molecular weight: 110,249 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Mer

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: Y749‑p, Y753‑p, Y754‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T458-p QVHNATCtVRIAAVT
0 3 S543-p NAFTEEDsELVVNyI
0 6 Y549-p DsELVVNyIAkkSFC
0 3 K552-ub LVVNyIAkkSFCRRA
0 1 K553-ub VVNyIAkkSFCRRAI
0 1 K576-ub VSEELQNkLEDVVID
0 13 K591-ub RNLLILGkILGEGEF
0 1 S613-p LKQEDGTsLKVAVKT
0 1 K615 QEDGTsLKVAVKTMk
0 1 K622-ub KVAVKTMkLDNSSQR
0 1 S645-p AACMKDFsHPNVIRL
0 1 T699-p PKHIPLQtLLKFMVD
1 445 Y749-p FGLSKKIysGDyyRQ
0 70 S750-p GLSKKIysGDyyRQG
1 402 Y753-p KKIysGDyyRQGRIA
1 71 Y754-p KIysGDyyRQGRIAK
0 6 R775-m2 AIESLADrVYTSKSD
0 1 K820-ub LLHGHRLkQPEDCLD
0 9 K856-ub VLRLQLEkLLESLPD
1 0 Y872 RNQADVIYVNTQLLE
0 1 K923-ub TAEVHDSkPHEGRyI
0 5 Y929-p SkPHEGRyILNGGsE
0 1 S935-p RyILNGGsEEWEDLT
  mouse

 
T453 QIHNATCTVRIAAIT
S538-p GAFSEEDsQLVVNYR
Y544 DsQLVVNYRAKKSFC
K547 LVVNYRAKKSFCRRA
K548 VVNYRAKKSFCRRAI
K571 VSEELQNKLEDVVID
K586 RNLLVLGKVLGEGEF
S608 LKQEDGTSQkVAVKT
K610-ub QEDGTSQkVAVKTMK
K617 kVAVKTMKLDNFSQR
N640 AACMKDFNHPNVIRL
T694 PKYIHLQTLLKFMMD
Y744-p FGLSKKIysGDyyRQ
S745-p GLSKKIysGDyyRQG
Y748-p KKIysGDyyRQGRIA
Y749-p KIysGDyyRQGRIAK
R770 AIESLADRVYTSKSD
K815 LLHGHRLKQPEDCLD
K851-ub VLRLQLEkLSESLPD
Y867-p QDKESIIyINTQLLE
N918 TAEVHENNLREERYI
Y924 NNLREERYILNGGNE
N930 RYILNGGNEEWEDVS
  rat

 
T453 QMHNATCTVRIAVIT
S538 GAFSEEDSQLVVNYR
Y544 DSQLVVNYRAKKSFC
K547 LVVNYRAKKSFCRRA
K548 VVNYRAKKSFCRRAI
K571 VSEELQNKLEDVVVD
K586 RNLLILGKVLGEGEF
S608 LKQEDGTSQKVAVKT
K610 QEDGTSQKVAVKTMK
K617 KVAVKTMKLDNFSLR
N640 AACMKDFNHPNVIRL
T694 PKSIPLQTLLKFMVD
Y744-p FGLSKKIySGDyyRQ
S745 GLSKKIySGDyyRQG
Y748-p KKIySGDyyRQGRIA
Y749-p KIySGDyyRQGRIAK
R770 AIESLADRVYTSKSD
K815 LLHGHRLKQPEDCLD
K851-ub VLRLQLEkLSESLPD
Y867 QDKESIIYINTQLLE
N918 MAEVHENNLHEERYI
Y924 NNLHEERYILNGGNE
N930 RYILNGGNEEWEDVA
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