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Protein Page:
FRMD7 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FRMD7 Plays a role in neurite development. May play a specific role in the control of eye movement and gaze stability. Defects in FRMD7 are the cause of nystagmus congenital X- linked type 1 (NYS1). NYS1 is a condition defined as conjugated, spontaneous and involuntary ocular oscillations that appear at birth or during the first three months of life. Other associated features may include mildly decreased visual acuity, strabismus, astigmatism, and occasionally head nodding. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Cellular Component: extracellular space; neuron projection; growth cone; cytoskeleton; cell soma
Reference #:  Q6ZUT3 (UniProtKB)
Alt. Names/Synonyms: FERM domain containing 7; FERM domain-containing protein 7; FLJ43346; FRMD7; NYS; NYS1
Gene Symbols: FRMD7
Molecular weight: 81,614 Da
Basal Isoelectric point: 8.05  Predict pI for various phosphorylation states
Select Structure to View Below

FRMD7

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y187-p IARKLDMyGIRPHPA
0 1 S260-p TLEFTMAsRDACKAF
0 1 K295 PKTLLCSKGSSFRYs
0 4 S302-p KGSSFRYsGRTQRQL
0 1 T388-p RNSALEVtFAtELEH
0 1 T391-p ALEVtFAtELEHSKP
0 1 S449-p SLSSFQTsCKFSGNH
  mouse

 
Y187 IARKLDMYGIRPQPA
S260 TLEFTMASRDACKAF
K295-ub PKTLLCSkGSSFRYs
S302-p kGSSFRYsGRTQRQL
T388 RNSAVEVTFAAELEH
A391 AVEVTFAAELEHSKP
T445 PLSSFQTTSKFADSH
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