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Protein Page:
AXL (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AXL a receptor tyrosine kinase that may function as a signal transducer between specific cell types of mesodermal origin. Interacts with SKP1. Overexpression in tissue culture causes oncogenic transformation. Overexpressed in several cancers including thyroid, ovarian, gastric, ER+ breast cancer and acute myeloid leukemia, where it is associated with poor prognosis. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Membrane protein, integral; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Protein kinase, TK; TK group; Axl family
Cellular Component: extracellular space; cell surface; integral to plasma membrane
Molecular Function: protein binding; protein heterodimerization activity; phosphatidylserine binding; phosphoinositide 3-kinase binding; transmembrane receptor protein tyrosine kinase activity; ATP binding; myosin heavy chain binding
Biological Process: forebrain cell migration; platelet activation; negative regulation of lymphocyte activation; organ regeneration; peptidyl-tyrosine phosphorylation; cell maturation; neuron migration; vagina development; negative regulation of tumor necrosis factor production; signal transduction; enzyme linked receptor protein signaling pathway; phagocytosis; positive regulation of natural killer cell differentiation; positive regulation of protein kinase B signaling cascade; erythrocyte homeostasis; ovulation cycle; natural killer cell differentiation; negative regulation of interferon-gamma production; cellular response to extracellular stimulus; protein kinase B signaling cascade; innate immune response; blood vessel remodeling; spermatogenesis; negative regulation of neuron apoptosis; inflammatory response; positive regulation of cytokine and chemokine mediated signaling pathway; apoptotic cell clearance; secretion by cell
Reference #:  P30530 (UniProtKB)
Alt. Names/Synonyms: AXL; AXL oncogene; AXL receptor tyrosine kinase; AXL transforming sequence/gene; JTK11; oncogene AXL; Tyrosine-protein kinase receptor UFO; UFO
Gene Symbols: AXL
Molecular weight: 98,336 Da
Basal Isoelectric point: 5.27  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AXL

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: Y821‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S100-p QDDWIVVsQLRITSL
0 1 S110 RITSLQLSDTGQYQC
0 1 Y115 QLSDTGQYQCLVFLG
0 1 T200-p HVPGLNKtssFsCEA
0 1 S201-p VPGLNKtssFsCEAH
0 1 S202-p PGLNKtssFsCEAHN
0 1 S204-p LNKtssFsCEAHNAK
0 1 T256 LSGIYPLTHCTLQAV
0 1 S265 CTLQAVLSNDGMGIQ
0 4 Y481-p RRKKETRyGEVFEPT
0 1 S503-p VRYRVRKsYSRRTTE
0 1 T508 RKsYSRRTTEATLNs
0 2 T509 KsYSRRTTEATLNsL
0 1 S515-p TTEATLNsLGISEEL
0 3 K523-ub LGISEELkEKLRDVM
0 8 K540-ub RHKVALGkTLGEGEF
0 1 K563-ub NQDDSILkVAVKTMK
0 1 K570 kVAVKTMKIAICTRS
0 1 S612-p FQGSEREsFPAPVVI
0 4 Y634-p DLHSFLLySRLGDQP
0 1 S635 LHSFLLySRLGDQPV
0 2 Y643-p RLGDQPVyLPTQMLV
0 1 T646 DQPVyLPTQMLVKFM
0 1 K666-ub GMEYLSTkRFIHRDL
0 55 Y698-p FGLSKKIyNGDyyRQ
1 747 Y702-p KKIyNGDyyRQGRIA
0 356 Y703-p KIyNGDyyRQGRIAK
0 6 R724-m2 AIESLADrVyTSKSD
0 2 Y726-p ESLADrVyTSKSDVW
0 12 Y759-p GVENSEIyDYLRQGN
0 1 Y761 ENSEIyDYLRQGNRL
0 1 K769 LRQGNRLKQPADCLD
1 3 Y779-p ADCLDGLyALMSRCW
1 1 Y821-p QEPDEILyVNMDEGG
1 20 Y866-p EVHPAGRyVLCPSTt
0 1 T873-p yVLCPSTtPsPAQPA
0 2 S875-p LCPSTtPsPAQPADR
0 2 S884-p AQPADRGsPAAPGQE
5724 : Phospho-Axl (Tyr702) (D12B2) Rabbit mAb
  mouse

 
S94 QDEWKVVSQLRISAL
S104-p RISALQLsDAGEyQC
Y109-p QLsDAGEyQCMVHLE
T194 QTPGLNKTSSFSCEA
S195 TPGLNKTSSFSCEAH
S196 PGLNKTSSFSCEAHN
S198 LNKTSSFSCEAHNAK
T250-p LSGIYPLtHCNLQAV
S259-p CNLQAVLsDDGVGIW
Y475-p RRKKETRyGEVFEPT
S497 VRYRVRKSYSRRttE
T502-p RKSYSRRttEATLNs
T503-p KSYSRRttEATLNsL
S509-p ttEATLNsLGISEEL
K517-ub LGISEELkEKLRDVM
K534-ub RHKVALGkTLGEGEF
K557 NQDDSILKVAVKTMk
K564-ub KVAVKTMkIAICTRS
G606 FQGSDREGFPEPVVI
Y628 DLHSFLLYsRLGDQP
S629-p LHSFLLYsRLGDQPV
F637 RLGDQPVFLPtQMLV
T640-p DQPVFLPtQMLVKFM
K660 GMEYLSTKRFIHRDL
Y692-p FGLSKKIyNGDyyRQ
Y696-p KKIyNGDyyRQGRIA
Y697-p KIyNGDyyRQGRIAK
R718 AIESLADRVYTSKSD
Y720 ESLADRVYTSKSDVW
Y753 GVENSEIYDyLRQGN
Y755-p ENSEIYDyLRQGNRL
K763-ub LRQGNRLkQPVDCLD
Y773 VDCLDGLYALMSRCW
Y815-p QEPDEILyVNMDEGG
Y860-p DVHSAGRyVLCPSTA
A867 yVLCPSTAPGPTLSA
G869 LCPSTAPGPTLSADR
C878 TLSADRGCPAPPGQE
5724 : Phospho-Axl (Tyr702) (D12B2) Rabbit mAb
  rat

 
S94 QDEWKVVSQLRISAL
S104 RISALQLSDAGEYQC
Y109 QLSDAGEYQCMVHLE
T194 QAPGLNKTSSFSCEA
S195 APGLNKTSSFSCEAH
S196 PGLNKTSSFSCEAHN
S198 LNKTSSFSCEAHNAK
T250 LSGIYPLTHCTLQAV
S259 CTLQAVLSNDGVGVW
Y475-p RRKKETRyGEVFEPT
S497 VRYRARKSYSRRTtE
T502 RKSYSRRTtEATLNS
T503-p KSYSRRTtEATLNSL
S509 TtEATLNSLGISEEL
K517 LGISEELKEKLRDVM
K534 RHKVALGKTLGEGEF
K557 NQDDSILKVAVKTMK
K564 KVAVKTMKIAICTRS
G606 FQGSDREGFPEPVVI
Y628 DLHSFLLYSRLGDQP
S629 LHSFLLYSRLGDQPV
F637 RLGDQPVFLPTQMLV
T640 DQPVFLPTQMLVKFM
K660 GMEYLSTKRFIHRDL
Y692-p FGLSKKIyNGDyyRQ
Y696-p KKIyNGDyyRQGRIA
Y697-p KIyNGDyyRQGRIAK
R718 AIESLADRVYTSKSD
Y720 ESLADRVYTSKSDVW
Y753 GVENSEIYDYLRQGN
Y755 ENSEIYDYLRQGNRL
K763 LRQGNRLKQPLDCLD
Y773 LDCLDGLYALMSRCW
Y815 QEPDEILYVNMDEGG
Y860 DVHSAGRYVLCPSTA
A867 YVLCPSTAPGPTLSA
G869 LCPSTAPGPTLSADR
C878 TLSADRGCPAPPGQE
5724 : Phospho-Axl (Tyr702) (D12B2) Rabbit mAb
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