a receptor tyrosine kinase that may function as a signal transducer between specific cell types of mesodermal origin. Interacts with SKP1. Overexpression in tissue culture causes oncogenic transformation. Overexpressed in several cancers including thyroid, ovarian, gastric, ER+ breast cancer and acute myeloid leukemia, where it is associated with poor prognosis. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, tyrosine (receptor); EC 22.214.171.124; Oncoprotein; Protein kinase, TK; Kinase, protein; Membrane protein, integral; TK group; Axl family
Cellular Component: extracellular space; cell surface; integral to plasma membrane; plasma membrane; intracellular
Molecular Function: protein binding; phosphatidylserine binding; protein heterodimerization activity; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding
Biological Process: forebrain cell migration; platelet activation; negative regulation of lymphocyte activation; entry of virus into host cell; peptidyl-tyrosine phosphorylation; cell maturation; neuron migration; vagina development; negative regulation of tumor necrosis factor production; signal transduction; positive regulation of pinocytosis; phagocytosis; positive regulation of natural killer cell differentiation; positive regulation of protein kinase B signaling cascade; erythrocyte homeostasis; ovulation cycle; natural killer cell differentiation; negative regulation of interferon-gamma production; protein kinase B signaling cascade; cellular response to extracellular stimulus; innate immune response; blood vessel remodeling; spermatogenesis; negative regulation of neuron apoptosis; vascular endothelial growth factor receptor signaling pathway; positive regulation of cytokine and chemokine mediated signaling pathway; inflammatory response; apoptotic cell clearance; secretion by cell
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.