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Protein Page:
ATP2C1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
ATP2C1 This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. Defects in ATP2C1 are the cause of Hailey-Hailey disease (HHD); also known as benign familial pemphigus. HHD is an autosomal dominant disorder characterized by persistent blisters and suprabasal cell separation (acantholysis) of the epidermis, due to impaired keratinocyte adhesion. Patients lacking all isoforms except isoform 2 have HHD. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transporter, ion channel; Transporter; Hydrolase; Membrane protein, multi-pass; Membrane protein, integral; EC 3.6.3.8
Cellular Component: Golgi membrane; Golgi apparatus; integral to membrane; trans-Golgi network
Molecular Function: manganese-transporting ATPase activity; signal transducer activity; calcium-transporting ATPase activity; manganese ion binding; metal ion binding; calcium ion binding; ATP binding
Biological Process: cellular calcium ion homeostasis; Golgi calcium ion homeostasis; epidermis development; positive regulation of I-kappaB kinase/NF-kappaB cascade; calcium ion transport; calcium-dependent cell-cell adhesion; actin cytoskeleton reorganization; manganese ion transport; cellular manganese ion homeostasis; signal transduction; Golgi calcium ion transport; transmembrane transport
Reference #:  P98194 (UniProtKB)
Alt. Names/Synonyms: AT2C1; ATP-dependent Ca(2+) pump PMR1; ATP2C1; ATP2C1A; ATPase 2C1; ATPase, Ca(2+)-sequestering; ATPase, Ca++ transporting, type 2C, member 1; BCPM; Calcium-transporting ATPase type 2C member 1; HHD; hSPCA1; HUSSY-28; KIAA1347; PMR1; PMR1L; secretory pathway Ca2+/Mn2+ ATPase 1; SPCA1
Gene Symbols: ATP2C1
Molecular weight: 100,577 Da
Basal Isoelectric point: 6.34  Predict pI for various phosphorylation states
Select Structure to View Below

ATP2C1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 31 K8-u MKVARFQkIPNGENE
0 2 K25-u IPVLTSKkASELPVS
0 1 K229 LVRCGKAKGVVIGTG
0 2 T420-p DAVIRNNtLMGKPTE
0 29 K496-u YCTTYQSkGQTLTLT
0 4 K514-u RDVYQQEkARMGSAG
0 2 T557-p TGVKEAVttLIASGV
0 2 T558-p GVKEAVttLIASGVS
0 1 K589-u SRLGLYSkTSQSVSG
0 2 S608-p AMDVQQLsQIVPKVA
0 1 Y618-p VPKVAVFyRASPRHK
0 4 K831-u LSSRSQTkSVFEIGL
0 2 K897-a IVAEIIKkVERSREK
0 2 K907-u RSREKIQkHVSSTsS
0 1 S911 KIQkHVSSTsSSFLE
0 1 S913-p QkHVSSTsSSFLEV_
  ATP2C1 iso8  
- gap
- gap
K224 LVRCGKAKGVVIGTG
T415 DAVIRNNTLMGKPTE
K491 YCTTYQSKGQTLTLT
K509 RDVYQQEKARMGSAG
T552 TGVKEAVTTLIASGV
T553 GVKEAVTTLIASGVS
K584 SRLGLYSKTSQSVSG
S603 AMDVQQLSQIVPKVA
Y613 VPKVAVFYRASPRHK
K826 LSSRSQTKSVFEIGL
K892 IVAEIIKKVERSREK
K902 RSREKIQKHVWLWER
S906 under review
S908 under review
  mouse

 
K8-u MKVARFQkIPNVENE
R25 IPVLTSKRASELAVS
K228-u LVRCGKAkGIVIGTG
T419-p DAVIRNNtLMGKPTE
K495-u YCTTYNSkGQTLALT
K513 RDLYQQEKARMGSAG
T556-p TGVKEAVttLIASGV
T557-p GVKEAVttLIASGVS
K588 SRLGLYSKTSQSVSG
S607 TMEVQHLSQIVPKVA
Y617 VPKVAVFYRASPRHK
K830 LSSRSQTKSVFEIGL
K896 IVSEIIKKVERSREK
K906-u RSREKVQkNAGsASS
S910-p KVQkNAGsASSSFLE
S912 QkNAGsASSSFLEV_
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