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Protein Page:
Tnk1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Tnk1 Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. Interacts with the SH3 domain of PLCG1 via its Pro-rich domain. Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain. Belongs to the protein kinase superfamily. Tyr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, tyrosine (non-receptor); Protein kinase, TK; EC 2.7.10.2; Kinase, protein; TK group; Ack family
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: membrane; cytoplasm; cell junction; cytosol
Molecular Function: protein binding; signal transducer activity; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding
Biological Process: peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; negative regulation of Ras protein signal transduction; negative regulation of cell growth; signal transduction; protein amino acid phosphorylation
Reference #:  Q13470 (UniProtKB)
Alt. Names/Synonyms: CD38 negative kinase 1; MGC46193; Non-receptor tyrosine-protein kinase TNK1; TNK1; tyrosine kinase, non-receptor, 1
Gene Symbols: TNK1
Molecular weight: 72,468 Da
Basal Isoelectric point: 9.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Tnk1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S60-p RPAQRRLsEALKRLR
0 1 S68-p EALKRLRsGPKSKNW
0 4 Y77-p PKSKNWVyKILGGFA
0 1 S94-p HKEPTLPsDsPRHLP
0 6 S96-p EPTLPsDsPRHLPEP
0 1 K141-ub LWTLPSGkSVPVAVK
0 1 T209-p GSLHARLtAPAPtPP
0 1 T214-p RLtAPAPtPPLLVAL
0 3 Y235-p QLAGAMAyLGARGLV
0 1 T248-p LVHRDLAtRNLLLAs
0 4 S255-p tRNLLLAsPRtIkVA
0 1 T258-p LLLAsPRtIkVADFG
0 1 K260-ub LAsPRtIkVADFGLV
1 4 Y277-p LGGARGRyVMGGPRP
0 3 Y287-p GGPRPIPyAWCAPES
0 3 Y353-p PLCSRALySLALRCW
0 2 S411 PITVIEGSSSFHSPD
0 1 K423 SPDSTIWKGQNGRTF
0 3 S468-p RGDQHPGsIDGDRKK
0 1 S500-p LERMKGIsRsLEsVL
1 17 S502-p RMKGIsRsLEsVLsL
0 2 S505-p GIsRsLEsVLsLGPR
0 2 S508-p RsLEsVLsLGPRPtG
0 7 T514-p LsLGPRPtGGGssPP
0 3 S518-p PRPtGGGssPPEIRQ
0 9 S519-p RPtGGGssPPEIRQA
0 1 S546-p RPPLSSSsPQPsQPs
0 1 S550-p SSSsPQPsQPsRERL
0 1 S553-p sPQPsQPsRERLPWP
0 3 S582-p ARKAAALsGGLLsDP
0 1 S587-p ALsGGLLsDPELQRK
0 1 T612-p VTHQECQtALGATGG
0 1 Y651-p CWRILEHyQWDLSAA
0 1 S659-p QWDLSAAsRyVLARP
0 27 Y661-p DLSAAsRyVLARP__
4553 : Phospho-TNK1 (Tyr277) Antibody
5638 : Phospho-TNK1 (Tyr277) (D46E7) Rabbit mAb
  Tnk1 iso2  
S60 RPAQRRLSEALKRLR
S68 EALKRLRSGPKSKNW
Y77 PKSKNWVYKILGGFA
S94 HKEPTLPSDSPRHLP
S96 EPTLPSDSPRHLPEP
K141 LWTLPSGKSVPVAVK
T209 GSLHARLTAPAPTPP
T214 RLTAPAPTPPLLVAL
Y235 QLAGAMAYLGARGLV
T248 LVHRDLATRNLLLAS
S255 TRNLLLASPRTIKVA
T258 LLLASPRTIKVADFG
K260 LASPRTIKVADFGLV
Y277 LGGARGRYVMGGPRP
Y287 GGPRPIPYAWCAPES
Y353 PLCSRALYSLALRCW
S411-p PITVIEGsPDSTIWk
K418-ub sPDSTIWkGQNGRTF
S463 RGDQHPGSIDGDRKK
S495 LERMKGISRSLESVL
S497 RMKGISRSLESVLSL
S500 GISRSLESVLSLGPR
S503 RSLESVLSLGPRPTG
T509 LSLGPRPTGGGSSPP
S513 PRPTGGGSSPPEIRQ
S514 RPTGGGSSPPEIRQA
S541 RPPLSSSSPQPSQPS
S545 SSSSPQPSQPSRERL
S548 SPQPSQPSRERLPWP
S577 ARKAAALSGGLLSDP
S582 ALSGGLLSDPELQRK
T607 VTHQECQTALGATGG
Y646 CWRILEHYQWDLSAA
S654 QWDLSAASRYVLARP
Y656 DLSAASRYVLARP__
4553 : Phospho-TNK1 (Tyr277) Antibody
5638 : Phospho-TNK1 (Tyr277) (D46E7) Rabbit mAb
  mouse

► Hide Isoforms
 
N60 RPAQRRLNEALKRYR
S68 EALKRYRSGVKSKNW
Y77 VKSKNWVYKILGGFA
S94 QKEIPPRSDSPLCFH
S96 EIPPRSDSPLCFHEP
Q141 LWTLPSGQSIPVAVK
T209 GSLHARLTAPAPTPP
T214 RLTAPAPTPPLPVAL
Y235 QLAGAMAYLGSCGLV
T248 LVHRDLATRNLLLAS
S255 TRNLLLASPRMIKVA
M258 LLLASPRMIKVADFG
K260 LASPRMIKVADFGLV
Y277 LGGARGRYVMGGPRP
Y287 GGPRPIPYAWCAPES
Y354 PLCSRALYSLALRCW
S412 PITIIEGSLDTATWK
K419 SLDTATWKGQNGRTL
G464 HGEKCRGGTDGDREK
S496 LQRMRGISKsLESVL
S498-p RMRGISKsLESVLSL
S501 GISKsLESVLSLGPR
S504 KsLESVLSLGPRPtG
T510-p LSLGPRPtGGGssPP
S514-p PRPtGGGssPPELRR
S515-p RPtGGGssPPELRRT
S549 RPPIICNSSQPTQPH
T553 ICNSSQPTQPHKARP
H556 SSQPTQPHKARPKRE
S582 ASKATVPSGGPLSDP
S587 VPSGGPLSDPEWQRK
V612 VTYQECQVALRTTGG
H651 CRRILEHHQWDLSAA
S659 QWDLSAASRYILARS
Y661 DLSAASRYILARS__
4553 : Phospho-TNK1 (Tyr277) Antibody
5638 : Phospho-TNK1 (Tyr277) (D46E7) Rabbit mAb
  Tnk1 iso2  
N60 RPAQRRLNEALKRYR
S68 EALKRYRSGVKSKNW
Y77 VKSKNWVYKILGGFA
S94 QKEIPPRSDSPLCFH
S96 EIPPRSDSPLCFHEP
Q141 LWTLPSGQSIPVAVK
T209 GSLHARLTAPAPTPP
T214 RLTAPAPTPPLPVAL
Y235 QLAGAMAYLGSCGLV
T248 LVHRDLATRNLLLAS
S255 TRNLLLASPRMIKVA
M258 LLLASPRMIKVADFG
K260 LASPRMIKVADFGLV
Y277 LGGARGRYVMGGPRP
Y287 GGPRPIPYAWCAPES
Y354 PLCSRALYSLALRCW
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
4553 : Phospho-TNK1 (Tyr277) Antibody
5638 : Phospho-TNK1 (Tyr277) (D46E7) Rabbit mAb
  rat

 
T60 RPAQRRLTEALKRYR
S68 EALKRYRSGVKSKNW
Y77 VKSKNWVYKILGGFA
S94 QKEIPPYSDSLPHLH
S96 EIPPYSDSLPHLHEP
Q141 LWTLPGGQSIPVAVK
T209 GSLHARLTAPAPMPP
M214 RLTAPAPMPPLPVTL
Y235 QLAGAMAYLGSCGLV
T248 LVHRDLATRNLLLAS
S255 TRNLLLASPRKIKVA
K258 LLLASPRKIKVADFG
K260 LASPRKIKVADFGLV
Y277 LGGARGRYVMGGPRP
Y287 GGPRPIPYAWCAPES
Y354 ALCSRALYSLALRCW
S412 PITIIEGSPDTTTWK
K419 SPDTTTWKGQNGRTL
G464 RGEKYRGGTDGDREK
S496 LQRMKGISKsLESVL
S498-p RMKGISKsLESVLSL
S501 GISKsLESVLSLGPR
S504 KsLESVLSLGPRPAG
A510 LSLGPRPAGGGSSPP
S514 PRPAGGGSSPPELRR
S515 RPAGGGSSPPELRRG
S551 RPPIICSSQPIQPHR
I554 IICSSQPIQPHRVRP
H557 SSQPIQPHRVRPKRE
P583 SSKVTIPPGGPLSDS
S588 IPPGGPLSDSEWQRK
M613 VTYQECQMALRTMGG
H652 CRRILEHHHWDLSAA
S660 HWDLSAASRYVLARS
Y662 DLSAASRYVLARS__
5638 : Phospho-TNK1 (Tyr277) (D46E7) Rabbit mAb
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