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Tnk1 (human)

Overview Tnk1 Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. Interacts with the SH3 domain of PLCG1 via its Pro-rich domain. Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain. Belongs to the protein kinase superfamily. Tyr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Protein kinase, tyrosine (non-receptor); Protein kinase, TK; EC 2.7.10.2; Kinase, protein; TK group; Ack family Cellular Component: membrane; cytoplasm Molecular Function: signal transducer activity; protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding Biological Process: protein amino acid autophosphorylation; signal transduction; protein amino acid phosphorylation Reference #:  Q13470 (UniProtKB) Alt. Names/Synonyms: CD38 negative kinase 1; MGC46193; Non-receptor tyrosine-protein kinase TNK1; TNK1; tyrosine kinase, non-receptor, 1 Gene Symbols: TNK1 Molecular weight: 72,468 Da Basal Isoelectric point: 9.57  Predict pI for various phosphorylation states CST Pathways:  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Tnk1

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		S60-p	RPAQRRLsEALKRLR
0	1		S68-p	EALKRLRsGPKSKNW
0	4		Y77-p	PKSKNWVyKILGGFA
0	1		S94-p	HKEPTLPsDsPRHLP
0	3		S96-p	EPTLPsDsPRHLPEP
0	1		K141-u	LWTLPSGkSVPVAVK
0	1		T209-p	GSLHARLtAPAPtPP
0	1		T214-p	RLtAPAPtPPLLVAL
0	3		Y235-p	QLAGAMAyLGARGLV
0	2		S255-p	TRNLLLAsPRtIkVA
0	1		T258-p	LLLAsPRtIkVADFG
0	1		K260-u	LAsPRtIkVADFGLV
1	4		Y277-p	LGGARGRyVMGGPRP
0	3		Y287-p	GGPRPIPyAWCAPES
0	3		Y353-p	PLCSRALySLALRCW
0	2		S411	PITVIEGSSSFHSPD
0	1		K423	SPDSTIWKGQNGRTF
0	1		S468-p	RGDQHPGsIDGDRKK
0	11		S502-p	RMKGISRsLESVLsL
0	1		S508-p	RsLESVLsLGPRPtG
0	4		T514-p	LsLGPRPtGGGssPP
0	2		S518-p	PRPtGGGssPPEIRQ
0	5		S519-p	RPtGGGssPPEIRQA
0	1		S546-p	RPPLSSSsPQPsQPs
0	1		S550-p	SSSsPQPsQPsRERL
0	1		S553-p	sPQPsQPsRERLPWP
0	2		S582-p	ARKAAALsGGLLsDP
0	1		S587-p	ALsGGLLsDPELQRK
0	1		T612-p	VTHQECQtALGATGG
0	1		Y651-p	CWRILEHyQWDLSAA
0	1		S659-p	QWDLSAAsRyVLARP
0	14		Y661-p	DLSAAsRyVLARP__

	Tnk1 iso2
S60	RPAQRRLSEALKRLR
S68	EALKRLRSGPKSKNW
Y77	PKSKNWVYKILGGFA
S94	HKEPTLPSDSPRHLP
S96	EPTLPSDSPRHLPEP
K141	LWTLPSGKSVPVAVK
T209	GSLHARLTAPAPTPP
T214	RLTAPAPTPPLLVAL
Y235	QLAGAMAYLGARGLV
S255	TRNLLLASPRTIKVA
T258	LLLASPRTIKVADFG
K260	LASPRTIKVADFGLV
Y277	LGGARGRYVMGGPRP
Y287	GGPRPIPYAWCAPES
Y353	PLCSRALYSLALRCW
S411-p	PITVIEGsPDSTIWk
K418-u	sPDSTIWkGQNGRTF
S463	RGDQHPGSIDGDRKK
S497	RMKGISRSLESVLSL
S503	RSLESVLSLGPRPTG
T509	LSLGPRPTGGGSSPP
S513	PRPTGGGSSPPEIRQ
S514	RPTGGGSSPPEIRQA
S541	RPPLSSSSPQPSQPS
S545	SSSSPQPSQPSRERL
S548	SPQPSQPSRERLPWP
S577	ARKAAALSGGLLSDP
S582	ALSGGLLSDPELQRK
T607	VTHQECQTALGATGG
Y646	CWRILEHYQWDLSAA
S654	QWDLSAASRYVLARP
Y656	DLSAASRYVLARP__

	mouse ► Hide Isoforms
N60	RPAQRRLNEALKRYR
S68	EALKRYRSGVKSKNW
Y77	VKSKNWVYKILGGFA
S94	QKEIPPRSDSPLCFH
S96	EIPPRSDSPLCFHEP
Q141	LWTLPSGQSIPVAVK
T209	GSLHARLTAPAPTPP
T214	RLTAPAPTPPLPVAL
Y235	QLAGAMAYLGSCGLV
S255	TRNLLLASPRMIKVA
M258	LLLASPRMIKVADFG
K260	LASPRMIKVADFGLV
Y277	LGGARGRYVMGGPRP
Y287	GGPRPIPYAWCAPES
Y354	PLCSRALYSLALRCW
S412	PITIIEGSLDTATWK
K419	SLDTATWKGQNGRTL
G464	HGEKCRGGTDGDREK
S498-p	RMRGISKsLESVLSL
S504	KsLESVLSLGPRPtG
T510-p	LSLGPRPtGGGssPP
S514-p	PRPtGGGssPPELRR
S515-p	RPtGGGssPPELRRT
S549	RPPIICNSSQPTQPH
T553	ICNSSQPTQPHKARP
H556	SSQPTQPHKARPKRE
S582	ASKATVPSGGPLSDP
S587	VPSGGPLSDPEWQRK
V612	VTYQECQVALRTTGG
H651	CRRILEHHQWDLSAA
S659	QWDLSAASRYILARS
Y661	DLSAASRYILARS__

	Tnk1 iso2
N60	RPAQRRLNEALKRYR
S68	EALKRYRSGVKSKNW
Y77	VKSKNWVYKILGGFA
S94	QKEIPPRSDSPLCFH
S96	EIPPRSDSPLCFHEP
Q141	LWTLPSGQSIPVAVK
T209	GSLHARLTAPAPTPP
T214	RLTAPAPTPPLPVAL
Y235	QLAGAMAYLGSCGLV
S255	TRNLLLASPRMIKVA
M258	LLLASPRMIKVADFG
K260	LASPRMIKVADFGLV
Y277	LGGARGRYVMGGPRP
Y287	GGPRPIPYAWCAPES
Y354	PLCSRALYSLALRCW
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	rat
T60	RPAQRRLTEALKRYR
S68	EALKRYRSGVKSKNW
Y77	VKSKNWVYKILGGFA
S94	QKEIPPYSDSLPHLH
S96	EIPPYSDSLPHLHEP
Q141	LWTLPGGQSIPVAVK
T209	GSLHARLTAPAPMPP
M214	RLTAPAPMPPLPVTL
Y235	QLAGAMAYLGSCGLV
S255	TRNLLLASPRKIKVA
K258	LLLASPRKIKVADFG
K260	LASPRKIKVADFGLV
Y277	LGGARGRYVMGGPRP
Y287	GGPRPIPYAWCAPES
Y354	ALCSRALYSLALRCW
S412	PITIIEGSPDTTTWK
K419	SPDTTTWKGQNGRTL
G464	RGEKYRGGTDGDREK
S498	RMKGISKSLESVLSL
S504	KSLESVLSLGPRPAG
A510	LSLGPRPAGGGSSPP
S514	PRPAGGGSSPPELRR
S515	RPAGGGSSPPELRRG
S551	RPPIICSSQPIQPHR
I554	IICSSQPIQPHRVRP
H557	SSQPIQPHRVRPKRE
P583	SSKVTIPPGGPLSDS
S588	IPPGGPLSDSEWQRK
M613	VTYQECQMALRTMGG
H652	CRRILEHHHWDLSAA
S660	HWDLSAASRYVLARS
Y662	DLSAASRYVLARS__

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