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Protein Page:
SCN10A (human)

Overview
SCN10A This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). Plays a role in neuropathic pain mechanisms. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, sodium
Cellular Component: voltage-gated sodium channel complex
Molecular Function: voltage-gated sodium channel activity
Biological Process: regulation of heart rate; sensory perception; sodium ion transport; sensory perception of pain
Reference #:  Q9Y5Y9 (UniProtKB)
Alt. Names/Synonyms: hPN3; Nav1.8; Peripheral nerve sodium channel 3; PN3; SCN10A; SCNAA; SNS; Sodium channel protein type 10 subunit alpha; Sodium channel protein type X subunit alpha; sodium channel, voltage-gated, type X, alpha polypeptide; sodium channel, voltage-gated, type X, alpha subunit; Voltage-gated sodium channel subunit alpha Nav1.8
Gene Symbols: SCN10A
Molecular weight: 220,626 Da
Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states
Select Structure to View Below

SCN10A

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S552 QQGPLPRSPLPQPSN
1 0 P557 PRSPLPQPSNPDSRH
0 3 S930-p RTKQALCsFFsRSCP
0 3 S933-p QALCsFFsRSCPFPQ
1 0 S1451 NAMKKLGSKKPQKPI
  mouse

 
S551 QAGPLPRSPLPQSPN
S556 PRSPLPQSPNPGPRR
S929 RASRAITSYIRSHCR
R932 RAITSYIRSHCRLRW
S1452 NAMKKLGSKKPQKPI
  rat

 
S551-p QTGPLPRsPLPQsPN
S556-p PRsPLPQsPNPGRRH
S929 RASRAIASYISSHCR
S932 RAIASYISSHCRFRW
S1452-p NAMKKLGsKKPQKPI
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