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Protein Page:
SCN10A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SCN10A This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). Plays a role in neuropathic pain mechanisms. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily. Note: This description may include information from UniProtKB.
Protein type: Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: voltage-gated sodium channel complex
Molecular Function: voltage-gated sodium channel activity
Biological Process: regulation of heart rate; sensory perception; sodium ion transport; generation of action potential; sensory perception of pain
Reference #:  Q9Y5Y9 (UniProtKB)
Alt. Names/Synonyms: hPN3; Nav1.8; Peripheral nerve sodium channel 3; PN3; SCN10A; SCNAA; SNS; Sodium channel protein type 10 subunit alpha; Sodium channel protein type X subunit alpha; sodium channel, voltage-gated, type X, alpha polypeptide; sodium channel, voltage-gated, type X, alpha subunit; Voltage-gated sodium channel subunit alpha Nav1.8
Gene Symbols: SCN10A
Molecular weight: 220,626 Da
Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states
Select Structure to View Below

SCN10A

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T91-p PFYSTHRtFMVLNKG
0 1 T100-p MVLNKGRtISRFsAT
0 1 S105-p GRtISRFsATRALWL
1 0 S552 QQGPLPRSPLPQPSN
1 0 P557 PRSPLPQPSNPDSRH
0 1 T618 MSVVSIITSVLEELE
0 1 S619 SVVSIITSVLEELEE
0 1 S627 VLEELEESEQKCPPC
0 1 Y723-p IIAFDPYyyFQKKWN
0 1 Y724-p IAFDPYyyFQKKWNI
0 3 S930-p RTKQALCsFFsRSCP
0 3 S933-p QALCsFFsRSCPFPQ
0 1 Y1188-p TVKALLEyTDRVFTF
0 1 Y1208-p MLLKWVAyGFKKYFT
0 1 K1441-ac FMTEEQKkYYNAMKK
1 0 S1451 NAMKKLGSKKPQKPI
0 1 T1497-p MITMMVEtDDQSEEK
0 1 S1838-p ATNLSKSsyEPIATT
0 1 Y1839-p TNLSKSsyEPIATTL
0 1 Y1862-p ATVIQKAyRSYVLHR
0 1 T1925-p PPSYESVtRGLsDRV
0 1 S1929-p ESVtRGLsDRVNMRT
  mouse

 
T91 PFYSTHRTFIVLDKS
T100 IVLDKSRTISRFSAT
S105 SRTISRFSATWALWL
S551 QAGPLPRSPLPQSPN
S556 PRSPLPQSPNPGPRR
T617-p MSVVSIMtsVIEELE
S618-p SVVSIMtsVIEELEE
S626-p VIEELEEsKLKCPPC
Y722 IIAFDPYYYFQKKWN
Y723 IAFDPYYYFQKKWNI
S929 RASRAITSYIRSHCR
R932 RAITSYIRSHCRLRW
Y1189 RVKSVLEYTDRVFTF
Y1209 MLLKWVAYGFKKYFT
K1442 FMTEEQKKYYNAMKK
S1452 NAMKKLGSKKPQKPI
T1498 MITMMVETDNQSEEK
S1839 ATNLSKASYEPIATT
Y1840 TNLSKASYEPIATTL
Y1863 ATIIQKAYRNYMLQR
T1926 PPSYDSVTRGLSDRA
S1930 DSVTRGLSDRANIST
  rat

 
T91 PFYSTHRTFMVLNKS
T100 MVLNKSRTISRFSAT
S105 SRTISRFSATWALWL
S551-p QTGPLPRsPLPQsPN
S556-p PRsPLPQsPNPGRRH
T617 MSVVSIMTSVIEELE
S618 SVVSIMTSVIEELEE
S626 VIEELEESKLKCPPC
Y722 IIAFDPYYYFQKKWN
Y723 IAFDPYYYFQKKWNI
S929 RASRAIASYISSHCR
S932 RAIASYISSHCRFRW
Y1189 RVKSVLEYTDRVFTF
Y1209 MLLKWVAYGFKKYFT
K1442 FMTEEQKKYYNAMKK
S1452-p NAMKKLGsKKPQKPI
T1498 MITMMVETDEQGEEK
S1839 ATNLSKASYEPIATT
Y1840 TNLSKASYEPIATTL
Y1863 ATVIQKAYRSYMLHR
T1924 PPSYDSVTRGLSDRA
S1928 DSVTRGLSDRANINP
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