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SCN10A (human)

Overview SCN10A This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). Plays a role in neuropathic pain mechanisms. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Channel, sodium Cellular Component: voltage-gated sodium channel complex Molecular Function: voltage-gated sodium channel activity Biological Process: regulation of heart rate; sensory perception; sodium ion transport Reference #:  Q9Y5Y9 (UniProtKB) Alt. Names/Synonyms: hPN3; Nav1.8; Peripheral nerve sodium channel 3; PN3; SCN10A; SCNAA; SNS; Sodium channel protein type 10 subunit alpha; Sodium channel protein type X subunit alpha; sodium channel, voltage-gated, type X, alpha polypeptide; sodium channel, voltage-gated, type X, alpha subunit; Voltage-gated sodium channel subunit alpha Nav1.8 Gene Symbols: SCN10A Molecular weight: 220,626 Da Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states

Select Structure to View Below SCN10A

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T100-p	MVLNKGRtISRFsAT
0	1		S105-p	GRtISRFsATRALWL
1	0		S552	QQGPLPRSPLPQPSN
1	0		P557	PRSPLPQPSNPDSRH
0	1		T618	MSVVSIITSVLEELE
0	1		S619	SVVSIITSVLEELEE
0	1		S627	VLEELEESEQKCPPC
0	1		Y723-p	IIAFDPYyyFQKKWN
0	1		Y724-p	IAFDPYyyFQKKWNI
0	3		S930-p	RTKQALCsFFsRSCP
0	3		S933-p	QALCsFFsRSCPFPQ
0	1		Y1188-p	TVKALLEyTDRVFTF
0	1		Y1208-p	MLLKWVAyGFKKYFT
0	1		K1441-a	FMTEEQKkYYNAMKK
1	0		S1451	NAMKKLGSKKPQKPI
0	1		T1497-p	MITMMVEtDDQSEEK
0	1		S1838-p	ATNLSKSsyEPIATT
0	1		Y1839-p	TNLSKSsyEPIATTL
0	1		Y1862-p	ATVIQKAyRSYVLHR
0	1		T1925-p	PPSYESVtRGLsDRV
0	1		S1929-p	ESVtRGLsDRVNMRT

	mouse
T100	IVLDKSRTISRFSAT
S105	SRTISRFSATWALWL
S551	QAGPLPRSPLPQSPN
S556	PRSPLPQSPNPGPRR
T617-p	MSVVSIMtsVIEELE
S618-p	SVVSIMtsVIEELEE
S626-p	VIEELEEsKLKCPPC
Y722	IIAFDPYYYFQKKWN
Y723	IAFDPYYYFQKKWNI
S929	RASRAITSYIRSHCR
R932	RAITSYIRSHCRLRW
Y1189	RVKSVLEYTDRVFTF
Y1209	MLLKWVAYGFKKYFT
K1442	FMTEEQKKYYNAMKK
S1452	NAMKKLGSKKPQKPI
T1498	MITMMVETDNQSEEK
S1839	ATNLSKASYEPIATT
Y1840	TNLSKASYEPIATTL
Y1863	ATIIQKAYRNYMLQR
T1926	PPSYDSVTRGLSDRA
S1930	DSVTRGLSDRANIST

	rat
T100	MVLNKSRTISRFSAT
S105	SRTISRFSATWALWL
S551-p	QTGPLPRsPLPQsPN
S556-p	PRsPLPQsPNPGRRH
T617	MSVVSIMTSVIEELE
S618	SVVSIMTSVIEELEE
S626	VIEELEESKLKCPPC
Y722	IIAFDPYYYFQKKWN
Y723	IAFDPYYYFQKKWNI
S929	RASRAIASYISSHCR
S932	RAIASYISSHCRFRW
Y1189	RVKSVLEYTDRVFTF
Y1209	MLLKWVAYGFKKYFT
K1442	FMTEEQKKYYNAMKK
S1452-p	NAMKKLGsKKPQKPI
T1498	MITMMVETDEQGEEK
S1839	ATNLSKASYEPIATT
Y1840	TNLSKASYEPIATTL
Y1863	ATVIQKAYRSYMLHR
T1924	PPSYDSVTRGLSDRA
S1928	DSVTRGLSDRANINP

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