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Protein Page:
TTBK2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TTBK2 Serine/threonine kinase which is able to phosphorylate tau on serines. Defects in TTBK2 are the cause of spinocerebellar ataxia type 11 (SCA11). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA11 is an autosomal dominant cerebellar ataxia (ADCA). It is a relatively benign, late-onset, slowly progressive neurologic disorder. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Protein kinase, CK1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CK1 group; TTBK family
Cellular Component: centriole; extracellular space; cytosol; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding
Biological Process: cell death; smoothened signaling pathway; peptidyl-serine phosphorylation; cilium biogenesis
Reference #:  Q6IQ55 (UniProtKB)
Alt. Names/Synonyms: KIAA0847; Tau-tubulin kinase 2; TTBK2
Gene Symbols: TTBK2
Molecular weight: 137,412 Da
Basal Isoelectric point: 6.54  Predict pI for various phosphorylation states
Select Structure to View Below

TTBK2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S2 ______MSGGGEQLD
0 52 - gap
0 3 - gap
0 8 - gap
0 2 - gap
0 7 - gap
0 5 - gap
0 2 - gap
0 3 T314-p TTTTTSTtPQLHTRL
0 3 S428-p GSPIRVRsEItQPDR
0 2 T431-p IRVRsEItQPDRDIP
0 3 S445-p PLVRKLRsIHsFELE
0 5 S448-p RKLRsIHsFELEKRL
0 5 T463-p TLEPKPDtDKFLETC
0 1 S499-p KPCVPAVsRTDHIWH
0 1 S592 VLQVLEASPQDEKLQ
0 2 S706 EPTVELYSPRENFSG
0 2 S751-p NIRESNKsQDLGPKE
0 3 S786-p EKSILLEsDNEDEKL
0 1 S817-p VIVEKDHsATTEPLD
0 1 S1103-p KVLGSSNsDSDLFSR
0 1 T1139-p GSPHNPKtPPKsPVV
0 1 S1143-p NPKtPPKsPVVPRRS
0 2 S1154-p PRRSPSAsPRSSSLP
  TTBK2 iso4  
- gap
S289-p GPGACISsssFSRMG
S290-p PGACISsssFSRMGS
S291-p GACISsssFSRMGSS
K369-a RFLEQQNkMLETKWS
K369-u RFLEQQNkMLETKWS
K537-u QRGELAIkDANAkLS
K542-u AIkDANAkLSELEAA
T719 TTTTTSTTPQLHTRL
S833 GSPIRVRSEITQPDR
T836 IRVRSEITQPDRDIP
S850 PLVRKLRSIHSFELE
S853 RKLRSIHSFELEKRL
T868 TLEPKPDTDKFLETC
S904 KPCVPAVSRTDHIWH
S997 VLQVLEASPQDEKLQ
S1111 EPTVELYSPRENFSG
S1156 NIRESNKSQDLGPKE
S1191 EKSILLESDNEDEKL
S1222 VIVEKDHSATTEPLD
S1508 KVLGSSNSDSDLFSR
T1544 GSPHNPKTPPKSPVV
S1548 NPKTPPKSPVVPRRS
S1559 PRRSPSASPRSSSLP
  mouse

 
S2-p ______MsGGGEQPD
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T314 TTTTTSATPQLHTRL
S428 GSPIRVRSEITQPDR
T431 IRVRSEITQPDRDVP
S445 PLVRKLRSIHsFELE
S448-p RKLRSIHsFELEKRL
T463 TLEPKPDTDKFLETC
T499 KPCVPVVTHTDHIWH
S592-p VLQVLEGsPQDEKIQ
S706-p EPTVELYsPRENFSG
S751 NMRDGDTSQDLGPKD
S786-p ERSLLLGsENEDERL
L816 VTAERAQLAATEPLH
S1102 KVLGSSNSDSDLFSR
T1138 GSPHNPKTPPKSPVV
S1142 NPKTPPKSPVVPRRS
S1153 PRRSPSASPRSSSLP
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