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Protein Page:
TTBK2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TTBK2 Serine/threonine kinase which is able to phosphorylate tau on serines. Defects in TTBK2 are the cause of spinocerebellar ataxia type 11 (SCA11). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA11 is an autosomal dominant cerebellar ataxia (ADCA). It is a relatively benign, late-onset, slowly progressive neurologic disorder. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, CK1; EC 2.7.11.1; CK1 group; TTBK family
Cellular Component: centriole; extracellular space; cytosol; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding
Biological Process: cell death; peptidyl-serine phosphorylation; smoothened signaling pathway; cilium biogenesis
Reference #:  Q6IQ55 (UniProtKB)
Alt. Names/Synonyms: KIAA0847; Tau-tubulin kinase 2; TTBK2
Gene Symbols: TTBK2
Molecular weight: 137,412 Da
Basal Isoelectric point: 6.54  Predict pI for various phosphorylation states
Select Structure to View Below

TTBK2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S2 ______MSGGGEQLD
0 1 S211-p GRHDDLWsLFYMLVE
0 1 K232 PWRKIKDKEQVGSIK
0 1 Y242-p VGSIKERyDHRLMLK
0 52 - gap
0 3 - gap
0 9 - gap
0 1 - gap
0 1 - gap
0 3 - gap
0 7 - gap
0 5 - gap
0 2 - gap
0 3 T314-p TTTTTSTtPQLHTRL
0 3 S428-p GSPIRVRsEItQPDR
0 2 T431-p IRVRsEItQPDRDIP
0 3 S445-p PLVRKLRsIHsFELE
0 5 S448-p RKLRsIHsFELEKRL
0 5 T463-p TLEPKPDtDKFLETC
0 1 K476-ub TCLEKMQkDTSAGKE
0 1 S499-p KPCVPAVsRTDHIWH
0 1 S592 VLQVLEASPQDEKLQ
0 1 T613-p NDHLKKEtsGVVLAL
0 1 S614-p DHLKKEtsGVVLALs
0 1 S621-p sGVVLALsAEGPPTA
0 2 S706 EPTVELYSPRENFSG
0 2 S751-p NIRESNKsQDLGPKE
0 4 S786-p EKSILLEsDNEDEKL
0 1 S817-p VIVEKDHsATTEPLD
0 1 T828-p EPLDVTKtQtFSVVP
0 1 T830-p LDVTKtQtFSVVPNQ
0 1 K845-ac DKNNEIMkLLTVGTS
0 1 K877-ac VAEMQKNkIsKDDDI
0 1 S879-p EMQKNkIsKDDDIMS
0 1 S960-p DSTLESSsPVsAKEK
0 1 S963-p LESSsPVsAKEKLLQ
0 1 K971 AKEKLLQKKAYQPDL
0 1 K985 LVKLLVEKRQFKSFL
0 1 S1039-p LSRSAEDsFLsPIIS
0 1 S1042-p SAEDsFLsPIISQSR
0 1 S1058 SKIPRPVSWVNTDQV
0 1 S1103-p KVLGSSNsDSDLFSR
0 1 T1139-p GSPHNPKtPPKsPVV
0 1 S1143-p NPKtPPKsPVVPRRS
0 1 S1152-p VVPRRSPsAsPRsSS
0 2 S1154-p PRRSPsAsPRsSSLP
0 1 S1157-p SPsAsPRsSSLPRTS
0 1 S1240-p QGKSKPAsKLsR___
0 1 S1243-p SKPAsKLsR______
  TTBK2 iso4  
- gap
S191 GRHDDLWSLFYMLVE
K212 PWRKIKDKEQVGSIK
Y222 VGSIKERYDHRLMLK
S289-p GPGACISsssFSRMG
S290-p PGACISsssFSRMGS
S291-p GACISsssFSRMGSS
K345-ub AVRTQEEkQIkTLNN
K348-ub TQEEkQIkTLNNKFF
K369-ac RFLEQQNkMLETKWS
K369-ub RFLEQQNkMLETKWS
K537-ub QRGELAIkDANAkLS
K542-ub AIkDANAkLSELEAA
T719 TTTTTSTTPQLHTRL
S833 GSPIRVRSEITQPDR
T836 IRVRSEITQPDRDIP
S850 PLVRKLRSIHSFELE
S853 RKLRSIHSFELEKRL
T868 TLEPKPDTDKFLETC
K881 TCLEKMQKDTSAGKE
S904 KPCVPAVSRTDHIWH
S997 VLQVLEASPQDEKLQ
T1018 NDHLKKETSGVVLAL
S1019 DHLKKETSGVVLALS
S1026 SGVVLALSAEGPPTA
S1111 EPTVELYSPRENFSG
S1156 NIRESNKSQDLGPKE
S1191 EKSILLESDNEDEKL
S1222 VIVEKDHSATTEPLD
T1233 EPLDVTKTQTFSVVP
T1235 LDVTKTQTFSVVPNQ
K1250 DKNNEIMKLLTVGTS
K1282 VAEMQKNKISKDDDI
S1284 EMQKNKISKDDDIMS
S1365 DSTLESSSPVSAKEK
S1368 LESSSPVSAKEKLLQ
K1376 AKEKLLQKKAYQPDL
K1390 LVKLLVEKRQFKSFL
S1444 LSRSAEDSFLSPIIS
S1447 SAEDSFLSPIISQSR
S1463 SKIPRPVSWVNTDQV
S1508 KVLGSSNSDSDLFSR
T1544 GSPHNPKTPPKSPVV
S1548 NPKTPPKSPVVPRRS
S1557 VVPRRSPSASPRSSS
S1559 PRRSPSASPRSSSLP
S1562 SPSASPRSSSLPRTS
S1645 QGKSKPASKLSR___
S1648 SKPASKLSR______
  mouse

 
S2-p ______MsGGGEQPD
S211 GRHDDLWSLFYMLVE
K232-ac PWRKIKDkEQVGSIK
Y242 VGSIKERYDHRLMLK
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T314 TTTTTSATPQLHTRL
S428 GSPIRVRSEITQPDR
T431 IRVRSEITQPDRDVP
S445 PLVRKLRSIHsFELE
S448-p RKLRSIHsFELEKRL
T463 TLEPKPDTDKFLETC
K476 TCMEKMQKDSSAGKE
T499 KPCVPVVTHTDHIWH
S592-p VLQVLEGsPQDEKIQ
S613 NHHLKKESSGVVLAL
S614 HHLKKESSGVVLALS
S621 SGVVLALSAECPATA
S706-p EPTVELYsPRENFSG
S751 NMRDGDTSQDLGPKD
S786-p ERSLLLGsENEDERL
L816 VTAERAQLAATEPLH
T827 EPLHVSETQNCSVLP
N829 LHVSETQNCSVLPNQ
K844 DKTHEIMKLLAVGTS
K876 MAAMQKNKLFKDDGI
F878 AMQKNKLFKDDGIQS
S959 DSTFESSSAISAKEK
S962 FESSSAISAKEKLLQ
K970-ac AKEKLLQkKAYQPEI
K984-ac IVKLLVEkRQFKSFL
S1038 LSRSVEDSFLSPIIS
S1041 SVEDSFLSPIISQAR
S1057-p SKIPRPVsWVSTDQI
S1102 KVLGSSNSDSDLFSR
T1138 GSPHNPKTPPKSPVV
S1142 NPKTPPKSPVVPRRS
S1151 VVPRRSPSASPRSSS
S1153 PRRSPSASPRSSSLP
S1156 SPSASPRSSSLPRTS
S1239 PGKSKPASKLSR___
S1242 SKPASKLSR______
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