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Protein Page:
UBE2T (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
UBE2T Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Belongs to the ubiquitin-conjugating enzyme family. Note: This description may include information from UniProtKB.
Protein type: Ligase; Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.19
Cellular Component: nucleoplasm; nucleus
Molecular Function: acid-amino acid ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; chromatin binding; ATP binding
Biological Process: protein monoubiquitination; protein autoubiquitination; DNA repair; response to DNA damage stimulus
Reference #:  Q9NPD8 (UniProtKB)
Alt. Names/Synonyms: Cell proliferation-inducing gene 50 protein; HSPC150; HSPC150 protein similar to ubiquitin-conjugating enzyme; PIG50; UBE2T; Ubiquitin carrier protein T; ubiquitin conjugating enzyme; Ubiquitin-conjugating enzyme E2 T; ubiquitin-conjugating enzyme E2T (putative); Ubiquitin-protein ligase T
Gene Symbols: UBE2T
Molecular weight: 22,521 Da
Basal Isoelectric point: 7.78  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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UBE2T

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 8 K28-ub GITCWQDkDQMDDLR
0 3 K48-ub GANTPYEkGVFKLEV
1 86 K91-ub RICLDVLkLPPKGAW
0 2 K141-ub YNKPAFLkNARQWTE
0 1 K156-ub KHARQKQkADEEEML
1 1 K182-ub HNSTQKRkAsQLVGI
0 30 S184-p STQKRkAsQLVGIEk
0 1 K191-ub sQLVGIEkkFHPDV_
0 1 K192-ub QLVGIEkkFHPDV__
0 2 H194 VGIEkkFHPDV____
  mouse

 
K28 GITCWQEKDQVADLR
K48 GANTPYEKGVFTLEV
K91-ub RICLDILkLPPKGAW
K141 YNKIAFLKKAKQWTE
K156 AHARQKQKADEEELG
K181 SHSTQKRKARPLGGM
R183 STQKRKARPLGGMEK
K190 RPLGGMEKKFsPDVQ
K191 PLGGMEKKFsPDVQR
S193-p GGMEKKFsPDVQRVY
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