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Protein Page:
LAMA2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
LAMA2 Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Defects in LAMA2 are the cause of merosin-deficient congenital muscular dystrophy type 1A (MDC1A). MDC1A is characterized by difficulty walking, hypotonia, proximal weakness, hyporeflexia, and white matter hypodensity on MRI. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted; Extracellular matrix; Motility/polarity/chemotaxis
Cellular Component: extracellular matrix; laminin-1 complex; dendritic spine; extracellular region; basement membrane; sarcolemma
Molecular Function: structural molecule activity; receptor binding
Biological Process: regulation of cell adhesion; positive regulation of synaptic transmission, cholinergic; axon guidance; extracellular matrix organization and biogenesis; muscle development; regulation of embryonic development; cell adhesion; regulation of cell migration; myelination in the peripheral nervous system
Reference #:  P24043 (UniProtKB)
Alt. Names/Synonyms: LAMA2; Laminin M chain; Laminin subunit alpha-2; laminin, alpha 2; Laminin-12 subunit alpha; Laminin-2 subunit alpha; Laminin-4 subunit alpha; LAMM; Merosin heavy chain
Gene Symbols: LAMA2
Molecular weight: 343,905 Da
Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states
Select Structure to View Below

LAMA2

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 R399 TCTDGFFRPKGVSPN
0 2 Y1249-p EGKKLMAyGGKLKyA
0 1 Y1255-p AyGGKLKyAIYFEAR
0 1 S1358-p QSRISEIsMEVAEQG
0 1 T1369-p AEQGRGTtMTPPADL
0 1 S1677 RTNTRAKSLGEFIkE
0 2 K1683-a KSLGEFIkELARDAE
0 1 K1943-m1 DEAEKVAkEAKDLAH
0 1 T2370 TVMFKFRTFSSSALL
0 1 Y2379 SSSALLMYLATRDLR
0 1 K2658-u VEQPIEVkKLFVGGA
0 1 S2772-p QFGLSRNsHIAIAFD
0 1 T2781-p IAIAFDDtKVKNRLT
0 1 K2856-u KIKIMRSkQEGILYV
  mouse

 
R395-m2 TCVDGFFrPKGVSPN
Y1245 EGKKLMAYGGKLKYA
Y1251 AYGGKLKYAIYFEAR
S1354 QSRISEISMEVAEPG
A1365 AEPGHVLAGSPPAHL
S1673-p RTNSRAEsLEEFIKG
K1679 EsLEEFIKGLVQDAE
R1939 DEAEKVAREAKELAQ
T2366-p TVMFKFRtFSSSALL
Y2375-p SSSALLMyLATRDLK
K2654 EEQPIEVKKLFVGGA
S2768 QFGLSRNSHIAIAFD
T2777 IAIAFDDTKVKNRLT
K2852 KIKIVRVKQEGILYV
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