Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Defects in LAMA2 are the cause of merosin-deficient congenital muscular dystrophy type 1A (MDC1A). MDC1A is characterized by difficulty walking, hypotonia, proximal weakness, hyporeflexia, and white matter hypodensity on MRI. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide; Extracellular matrix; Motility/polarity/chemotaxis
Biological Process: regulation of cell adhesion; axon guidance; positive regulation of synaptic transmission, cholinergic; extracellular matrix organization and biogenesis; muscle development; regulation of embryonic development; cell adhesion; regulation of cell migration; myelination in the peripheral nervous system
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.