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Protein Page:
DLST (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DLST The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). Forms a 24-polypeptide structural core with octahedral symmetry. Belongs to the 2-oxoacid dehydrogenase family. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; EC 2.3.1.61; Carbohydrate Metabolism - citrate (TCA) cycle; Amino Acid Metabolism - lysine degradation; Transferase
Cellular Component: membrane; mitochondrial matrix; nucleus; oxoglutarate dehydrogenase complex
Molecular Function: dihydrolipoyllysine-residue succinyltransferase activity
Biological Process: cellular metabolic process; generation of precursor metabolites and energy; tricarboxylic acid cycle; L-lysine catabolic process to acetyl-CoA via saccharopine; lysine catabolic process
Reference #:  P36957 (UniProtKB)
Alt. Names/Synonyms: 2-oxoglutarate dehydrogenase complex component E2; dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex); Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; DLST; DLTS; E2K; ODO2; OGDC-E2
Gene Symbols: DLST
Molecular weight: 48,755 Da
Basal Isoelectric point: 9.1  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DLST

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K74-sc KDDLVTVkTPAFAEs
0 5 S81-p kTPAFAEsVTEGDVR
0 1 T138-p GGKVEGGtPLFTLRK
0 1 K154 GAAPAKAKPAEAPAA
0 1 K203-ub GKPVSAVkPTVAPPL
0 1 K217-ub LAEPGAGkGLRSEHR
0 1 K226 LRSEHREKMNRMRQR
0 89 K267-ac QEMRARHkEAFLkkH
0 1 K267-sc QEMRARHkEAFLkkH
0 143 K272-ac RHkEAFLkkHNLkLG
0 1 K272 RHkEAFLKkHNLkLG
0 5 K273-ac HkEAFLkkHNLkLGF
0 27 K277-ac FLkkHNLkLGFMSAF
0 2 K277-sc FLkkHNLkLGFMSAF
0 1 S282 NLkLGFMSAFVKASA
0 1 K307-ub AVIDDTTkEVVYRDY
0 2 K307 AVIDDTTKEVVYRDY
0 2 K307-ac AVIDDTTkEVVYRDY
0 1 K353-ub TITELGEkARKNELA
  mouse

 
Q75 KNDVITVQTPAFAEs
S82-p QTPAFAEsVTEGDVR
T139 GGKVEGGTPLFTLRK
K155-ac GAAPAKAkPAETPAP
K204 SKPVSAIKPTAAPPL
K218 LAEAGAAKGLRSEHR
K227-ac LRSEHREkMNRMRQR
K268-ac QEMRARHkDAFLkkH
K268-sc QEMRARHkDAFLkkH
K273-ac RHkDAFLkkHNLkLG
K273-sc RHkDAFLkkHNLkLG
K274-ac HkDAFLkkHNLkLGF
K278-ac FLkkHNLkLGFMsAF
K278-sc FLkkHNLkLGFMsAF
S283-p NLkLGFMsAFVKASA
K308 AVIDDATKEVVYRDY
K308-sc AVIDDATkEVVYRDY
K308-ac AVIDDATkEVVYRDY
K354 TINELGEKARKNELA
  rat

 
Q75 KNDVITVQTPAFAES
S82 QTPAFAESVTEGDVR
T139 GGKVEGGTPLFTLRK
K155 GAAPAKAKPAEAPAT
K204 SKPVSAIKPTAAPPL
K218 LAEAGAAKGLRSEHR
K227 LRSEHREKMNRMRQR
K268-ac QEMRARHkDAFLkKH
K268 QEMRARHKDAFLkKH
K273-ac RHkDAFLkKHNLkLG
K273 RHkDAFLKKHNLkLG
K274 HkDAFLkKHNLkLGF
K278-ac FLkKHNLkLGFMSAF
K278 FLkKHNLKLGFMSAF
S283 NLkLGFMSAFVKASA
K308 AVIDDATKEVVYRDY
K308 AVIDDATKEVVYRDY
K308-ac AVIDDATkEVVYRDY
K354 TINELGEKARKNELA
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