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Protein Page:
LIPH (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
LIPH Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). Defects in LIPH are the cause of hypotrichosis type 7 (HYPT7); also known as alopecia universalis congenita Mari type. A condition characterized by the presence of less than the normal amount of hair. Affected individuals have sparse or absent scalp, axillary and body hair and sparse eyebrows and eyelashes. Defects in LIPH are the cause of woolly hair autosomal recessive type 2 (ARWH2). A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals may present with hypotrichosis. Belongs to the AB hydrolase superfamily. Lipase family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; EC 3.1.1.-; Phospholipase; Secreted
Cellular Component: extracellular space; plasma membrane
Molecular Function: heparin binding; phospholipase activity
Biological Process: lipid catabolic process
Reference #:  Q8WWY8 (UniProtKB)
Alt. Names/Synonyms: AH; lipase H; Lipase member H; lipase, member H; LIPH; LPD lipase-related protein; LPDLR; Membrane-associated phosphatidic acid-selective phospholipase A1-alpha; membrane-bound phosphatidic acid-selective phospholipase A1; mPA-PLA1; mPA-PLA1 alpha; MPAPLA1; Phospholipase A1 member B; PLA1B
Gene Symbols: LIPH
Molecular weight: 50,859 Da
Basal Isoelectric point: 7.15  Predict pI for various phosphorylation states
Select Structure to View Below

LIPH

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K49-ub RLMLYTRkNLTCAQT
0 1 K69-ub FGNLNVTkKTTFIVH
0 1 S393-p LDKVAAIsLMFSTGS
  mouse

 
R49 RLMLYTQRDQTCAQI
K69 LGSLNVTKKTTFIIH
S393 LDKVAEISLLFSTGS
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