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Protein Page:
GYS2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GYS2 Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. Defects in GYS2 are the cause of glycogen storage disease type 0 (GSD0); A metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood, high blood ketones and low alanine and lactate concentrations. Although feeding relieves symptoms, it often results in postprandial hyperglycemia and hyperlactatemia. Belongs to the glycosyltransferase 3 family. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Cytoskeletal protein; Transferase
Chromosomal Location of Human Ortholog: 12p12.2
Cellular Component: cortical actin cytoskeleton; cytoskeleton; ectoplasm; cytoplasm; cell cortex; cytosol
Molecular Function: protein homodimerization activity; glycogen (starch) synthase activity
Biological Process: generation of precursor metabolites and energy; glycogen biosynthetic process; carbohydrate metabolic process; response to glucose stimulus; glucose metabolic process
Reference #:  P54840 (UniProtKB)
Alt. Names/Synonyms: Glycogen [starch] synthase, liver; glycogen synthase 2 (liver); GYS2
Gene Symbols: GYS2
Molecular weight: 80,989 Da
Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  Insulin Receptor Signaling  |  PI3K/Akt Signaling
Select Structure to View Below

GYS2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S6-p __MLRGRsLsVtsLG
1 5 S8-p MLRGRsLsVtsLGGL
0 4 T10-p RGRsLsVtsLGGLPQ
1 5 S11-p GRsLsVtsLGGLPQW
0 92 Y45-p TNKVGGIytVIQtKA
0 3 T46-p NKVGGIytVIQtKAK
0 1 T50-p GIytVIQtKAKTTAD
0 1 K53 tVIQtKAKTTADEWG
0 1 R90 PVNDAVRRAVDAMNK
0 1 K97 RAVDAMNKHGCQVHF
0 1 T203-p LPIATIFtTHATLLG
0 1 K273 AEHMLKRKPDVVTPN
0 3 K285 TPNGLNVKKFSAVHE
0 1 K371-ac VFFIMPAkTNNFNVE
0 3 K381-ub NFNVETLkGQAVRkQ
0 1 K387-ac LkGQAVRkQLWDVAH
0 1 K387 LkGQAVRKQLWDVAH
0 1 K397-ac WDVAHSVkEKFGKKL
0 1 K397 WDVAHSVKEKFGKKL
0 1 K403 VkEKFGKKLyDALLR
0 1 Y405-p EKFGKKLyDALLRGE
0 1 R410 KLyDALLRGEIPDLN
0 1 R422 DLNDILDRDDLtIMK
0 1 T426-p ILDRDDLtIMKRAIF
0 1 K429 RDDLtIMKRAIFSTQ
0 2 S439 IFSTQRQSLPPVTTH
0 1 K620 LSRAFPDKFHVELTs
0 1 T626 DKFHVELTsPPTTEG
0 3 S627-p KFHVELTsPPTTEGF
0 1 S640 GFKYPRPSSVPPSPS
1 0 S641 FKYPRPSSVPPSPSG
1 0 S645 RPSSVPPSPSGSQAS
0 1 A651 PSPSGSQASSPQSSD
0 1 S657 QASSPQSSDVEDEVE
0 1 K682 ERDRLNIKsPFsLsH
0 5 S683-p RDRLNIKsPFsLsHV
0 2 S686-p LNIKsPFsLsHVPHG
0 1 S688-p IKsPFsLsHVPHGkk
0 1 H692 FsLsHVPHGkkkLHG
0 1 K694-ac LsHVPHGkkkLHGEY
0 1 K695-ac sHVPHGkkkLHGEYK
0 1 K696-ac HVPHGkkkLHGEYKN
  mouse

 
S6-p __MLRGRsLsVtsLG
S8-p MLRGRsLsVtsLGGL
T10-p RGRsLsVtsLGGLPV
S11-p GRsLsVtsLGGLPVW
C45 TNKVGGICTVIQTKA
T46 NKVGGICTVIQTKAk
T50 GICTVIQTKAkTTAD
K53-ub TVIQTKAkTTADEWG
K90-ac PTNDAVRkAVDAMNk
K97-ub kAVDAMNkHGCQVHF
T203 LPIATVFTTHATLLG
K273-ub AEHMLKRkPDVVTPN
K285-ac TPNGLNVkKFSAVHE
K371 VFFIMPAKTNNFNVE
K381-ub NFNVETLkGQAVRkQ
K387 LkGQAVRKQLWDTVH
K387-ub LkGQAVRkQLWDTVH
K397 WDTVHCLKEKFGKkL
K397-ub WDTVHCLkEKFGKkL
K403-ub LkEKFGKkLYDGLLr
Y405 EKFGKkLYDGLLrGE
R410-m1 kLYDGLLrGEIPDMN
R422-m1 DMNSILDrDDLTIMk
T426 ILDrDDLTIMkRAIF
K429-ub rDDLTIMkRAIFSTQ
S439-p IFSTQRQsLPPVTTH
K620-ub LSRAFPDkFHLEPts
T626-p DkFHLEPtsPPTTDG
S627-p kFHLEPtsPPTTDGF
S640 GFKYPRPSSVPPSPS
S641 FKYPRPSSVPPSPSG
S645 RPSSVPPSPSGSQAS
A651 PSPSGSQASSPQCsD
S657-p QASSPQCsDAEDEED
K683-ub ERDRLNIksPFSLNH
S684-p RDRLNIksPFSLNHF
S687 LNIksPFSLNHFPkG
N689 IksPFSLNHFPkGKK
K693-ub FSLNHFPkGKKKLHG
K695 LNHFPkGKKKLHGEY
K696 NHFPkGKKKLHGEYK
K697 HFPkGKKKLHGEYKN
  rat

 
S6-p __MLRGRsLsVtsLG
S8-p MLRGRsLsVtsLGGL
T10-p RGRsLsVtsLGGLPA
S11-p GRsLsVtsLGGLPAW
C45 TNKVGGICTVIQSKA
T46 NKVGGICTVIQSKAK
S50 GICTVIQSKAKTTAN
K53 TVIQSKAKTTANEWG
K90 PANDAVRKAVDAMNK
K97 KAVDAMNKHGCQVHF
T203 LPIATIFTTHATLLG
K273 ADHMLKRKPDVVTPN
K285 TPNGLNVKKFSAVHE
K371 VFFIMPAKTNNFNVE
K381 NFNVETLKGQAVRKQ
K387 LKGQAVRKQLWDTVH
K387 LKGQAVRKQLWDTVH
K397 WDTVHCMKEKFGKKL
K397 WDTVHCMKEKFGKKL
K403 MKEKFGKKLYDGLLR
Y405 EKFGKKLYDGLLRGE
R410 KLYDGLLRGEIPDMN
R422 DMNSILDRDDLTIMK
T426 ILDRDDLTIMKRAIF
K429 RDDLTIMKRAIFSTQ
S439 IFSTQRHSLPPVTTH
K620 LSRAFPDKFHLEPTs
T626 DKFHLEPTsPPTTDG
S627-p KFHLEPTsPPTTDGF
S640-p GFKYPRPssVPPsPS
S641-p FKYPRPssVPPsPSG
S645-p RPssVPPsPSGSQtS
T651-p PsPSGSQtSSPQSSD
S657 QtSSPQSSDVENEGD
K683 ERDRLNIKSPFSLNH
S684 RDRLNIKSPFSLNHI
S687 LNIKSPFSLNHIPKG
N689 IKSPFSLNHIPKGKK
K693 FSLNHIPKGKKKLHG
K695 LNHIPKGKKKLHGEY
K696 NHIPKGKKKLHGEYK
K697 HIPKGKKKLHGEYKN
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