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CCR2 (human)

Overview CCR2 a seven transmembrane protein closely related to CCR1. Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. Transduces a signal by increasing the intracellular calcium ions level. Alternative co receptor with CD4 for HIV-1 infection. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB. Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR Cellular Component: cell soma; perinuclear region of cytoplasm; integral to plasma membrane; dendrite; cytoplasm; plasma membrane; integral to membrane; perikaryon; cytosol Molecular Function: protein homodimerization activity; CCR2 chemokine receptor binding; C-C chemokine receptor activity; chemokine receptor activity Biological Process: positive regulation of T-helper 1 type immune response; chemotaxis; elevation of cytosolic calcium ion concentration; response to wounding; dendritic cell chemotaxis; cellular homeostasis; inflammatory response; positive regulation of tumor necrosis factor biosynthetic process; cytokine and chemokine mediated signaling pathway; negative regulation of adenylate cyclase activity; JAK-STAT cascade; cellular calcium ion homeostasis; positive regulation of interferon-gamma production; negative regulation of angiogenesis; negative regulation of T-helper 2 type immune response; virus-host interaction; positive regulation of interleukin-2 production; cellular defense response; innate immune response; immune response; positive regulation of alpha-beta T cell proliferation; blood vessel remodeling; negative regulation of eosinophil degranulation; positive regulation of T cell activation; positive regulation of inflammatory response Reference #:  P41597 (UniProtKB) Alt. Names/Synonyms: C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; CCR2A; CCR2B; CD192; chemokine (C-C motif) receptor 2; CKR2; CKR2A; CKR2B; CMKBR2; FLJ78302; MCP-1 receptor; MCP-1-R; MGC103828; MGC111760; MGC168006; Monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor Gene Symbols: CCR2 Molecular weight: 41,915 Da Basal Isoelectric point: 9.24  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CCR2 1KAD - A=1-343 (human) 1KP1 - A=1-343 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1KAD 1KP1  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
molecular association, regulation: Y139‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		Y139-p	ILLTIDRyLAIVHAV
0	1		-	under review

	mouse
Y152	ILLTIDRYLAIVHAV
S370-p	STGEQEVsVGL____

	rat
Y152	ILLTIDRYLAIVHAV
S370	STGEQEVSVGL____

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