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Protein Page:
RAB23 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
RAB23 Defects in RAB23 are the cause of acrocephalopolysyndactyly type 2 (ACPS2). A syndrome characterized by craniosynostosis, polysyndactyly, obesity, and cardiac defects. Belongs to the small GTPase superfamily. Rab family. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric; G protein; G protein, monomeric, Rab
Cellular Component: phagocytic vesicle membrane; cytoplasm; plasma membrane; endosome membrane; autophagic vacuole; phagocytic vesicle
Molecular Function: GTPase activity; GTP binding
Biological Process: negative regulation of proteolysis; protein transport; GTP catabolic process; small GTPase mediated signal transduction; spinal cord dorsal/ventral patterning; cellular defense response; embryonic digit morphogenesis; negative regulation of transcription factor import into nucleus; autophagic vacuole formation; regulation of smoothened signaling pathway
Reference #:  Q9ULC3 (UniProtKB)
Alt. Names/Synonyms: DKFZp781H0695; HSPC137; MGC8900; RAB family small GTP binding protein RAB 23; RAB23; RAB23, member RAS oncogene family; Ras-related protein Rab-23
Gene Symbols: RAB23
Molecular weight: 26,659 Da
Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states
Select Structure to View Below

RAB23

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K132 LLDDSCIKNEEAEAL
0 2 K163-u LNVNEVFkyLAEKYL
0 9 Y164-p NVNEVFkyLAEKYLQ
0 1 S186-p EDPELTHssSNKIGV
0 1 S187-p DPELTHssSNKIGVF
0 6 S197-p KIGVFNTsGGsHSGQ
0 3 S200-p VFNTsGGsHSGQNsG
0 2 S206-p GsHSGQNsGtLNGGD
0 6 T208-p HSGQNsGtLNGGDVI
  mouse

 
K132-u LLDDSCIkNEEAEGL
K163-u LNVSEVFkYLAEKHL
Y164 NVSEVFkYLAEKHLQ
S186 EDPEQTHSSSNKIGV
S187 DPEQTHSSSNKIGVF
S197-p KIGVFNAsVGsHLGQ
S200-p VFNAsVGsHLGQNSS
S206 GsHLGQNSSSLNGGD
S208 HLGQNSSSLNGGDVI
  rat

 
K132 LLDDSCIKNEEAEGL
K163 LNVNEVFKyLAEKHL
Y164-p NVNEVFKyLAEKHLQ
S186 DEPEQTHSSSNKIGV
S187 EPEQTHSSSNKIGVF
S197 KIGVFNASVGSHLGQ
S200 VFNASVGSHLGQNSS
S206 GSHLGQNSSSLNGGD
S208 HLGQNSSSLNGGDVI
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