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IL27-beta
Cytokine with pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon- gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. Belongs to the type I cytokine receptor family. Type 3 subfamily. Note: This description may include information from UniProtKB.
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| Protein type: Secreted; Secreted, signal peptide |
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Cellular Component: extracellular space; plasma membrane
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Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-27 receptor binding; cytokine activity
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Biological Process: T-helper 1 type immune response; cytokine and chemokine mediated signaling pathway; positive regulation of alpha-beta T cell proliferation; humoral immune response; positive regulation of interferon-gamma biosynthetic process
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Reference #:
Q14213 (UniProtKB)
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| Alt. Names/Synonyms: EBI3; Epstein-Barr virus induced gene 3; IL27-beta; IL27B; interleukin-27 beta |
| Gene Symbols: EBI3 |
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Molecular weight: 25,396 Da
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Basal Isoelectric point: 9.41
Predict pI for various phosphorylation states
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