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ERCC2
ATP-dependent 5'-3' DNA helicase, component of the core- TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. Might also have a role in aging process and could play a causative role in the generation of skin cancers. Belongs to the helicase family. RAD3/XPD subfamily. One of the six subunits forming the core-TFIIH basal transcription factor which associates with the CAK complex composed of CDK7, CCNH/cyclin H and MNAT1 to form the TFIIH basal transcription factor. The interaction with GTF2H2 results in the stimulation of the 5'-->3' helicase activity. Interacts with Epstein-Barr virus EBNA2. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.6.4.12; EC 3.6.1.-; Helicase |
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Cellular Component: nucleoplasm; holo TFIIH complex; cytoplasm; spindle; nucleus; cyclin-dependent protein kinase activating kinase holoenzyme complex
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Molecular Function: ATP-dependent DNA helicase activity; protein C-terminus binding; RNA polymerase subunit kinase activity; DNA-dependent ATPase activity; protein binding; DNA binding; 4 iron, 4 sulfur cluster binding; metal ion binding; protein N-terminus binding; 5'-3' DNA helicase activity; ATP binding; protein kinase activity
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Biological Process: transcription from RNA polymerase II promoter; skin development; extracellular matrix organization and biogenesis; erythrocyte maturation; viral reproduction; apoptosis; positive regulation of viral transcription; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; bone mineralization; embryonic cleavage; post-embryonic development; chromosome segregation; mRNA capping; UV protection; transcription-coupled nucleotide-excision repair; nucleotide-excision repair, DNA damage removal; positive regulation of DNA binding; aging; transcription initiation from RNA polymerase II promoter; in utero embryonic development; multicellular organism growth; hair cell differentiation; nucleotide-excision repair, DNA incision; transcription from RNA polymerase I promoter; RNA elongation from RNA polymerase I promoter; termination of RNA polymerase I transcription; DNA repair; hair follicle maturation; cell proliferation; myelin formation in the central nervous system; nucleotide-excision repair; spinal cord development; virus-host interaction; RNA elongation from RNA polymerase II promoter; induction of apoptosis; response to hypoxia; gene expression; positive regulation of transcription from RNA polymerase II promoter; response to oxidative stress; transcription initiation from RNA polymerase I promoter; cell cycle checkpoint; negative regulation of apoptosis
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Reference #:
P18074 (UniProtKB)
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| Alt. Names/Synonyms: Basic transcription factor 2 80 kDa subunit; BTF2 p80; COFS2; CXPD; DNA excision repair protein ERCC-2; DNA repair protein complementing XP-D cells; EM9; ERCC2; excision repair cross-complementing rodent repair deficiency, complementation group 2; MGC102762; MGC126218; MGC126219; TFIIH 80 kDa subunit; TFIIH basal transcription factor complex 80 kDa subunit; TFIIH basal transcription factor complex helicase subunit; TFIIH p80; TTD; xeroderma pigmentosum complementary group D; Xeroderma pigmentosum group D-complementing protein; XPD; XPDC |
| Gene Symbols: ERCC2 |
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Molecular weight: 86,909 Da
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Basal Isoelectric point: 6.72
Predict pI for various phosphorylation states
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CST Pathways:
Protein Acetylation
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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