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Protein Page:
MRLC1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MRLC1 Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. Myosin is an hexamer of 2 heavy chains and 4 light chains. Smooth muscle tissues and in some, but not all, nonmuscle cells. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Contractile protein
Cellular Component: stress fiber; muscle myosin complex; cytosol; Z disc
Molecular Function: structural constituent of muscle; calcium ion binding
Biological Process: axon guidance; muscle contraction; regulation of muscle contraction
Reference #:  P24844 (UniProtKB)
Alt. Names/Synonyms: 20 kDa myosin light chain; LC20; MGC3505; MLC-2C; MLC2; MRLC1; MYL9; myosin regulatory light chain 1; Myosin regulatory light chain 2, smooth muscle isoform; Myosin regulatory light chain 9; Myosin regulatory light chain MRLC1; Myosin regulatory light polypeptide 9; Myosin RLC; myosin, light chain 9, regulatory; myosin, light polypeptide 9, regulatory; MYRL2
Gene Symbols: MYL9
Molecular weight: 19,827 Da
Basal Isoelectric point: 4.8  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  TGF-├č Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MRLC1

Protein Structure Not Found.


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Sites Implicated In
cell adhesion, altered: S20‑p
cell motility, altered: S20‑p
cytoskeletal reorganization: S20‑p
activity, induced: S20‑p
intracellular localization: S20‑p
molecular association, regulation: S20‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
5 0 S2-p ______MssKRAKAK
5 0 S3-p _____MssKRAKAKt
4 4 T10-p sKRAKAKttKKRPQR
0 6 T11-p KRAKAKttKKRPQRA
18 302 T19-p KKRPQRAtsNVFAMF
34 321 S20-p KRPQRAtsNVFAMFD
0 11 S29-p VFAMFDQsQIQEFKE
0 4 K51-ub NRDGFIDkEDLHDML
0 1 S115-p ACFDEEAsGFIHEDH
0 1 Y143-p DEEVDEMyREAPIDK
0 1 K150 yREAPIDKKGNFNyV
0 1 K151 REAPIDKKGNFNyVE
0 21 Y156-p DKKGNFNyVEFTRIL
0 1 K164-ub VEFTRILkHGAkDKD
0 1 K168-ac RILkHGAkDKDD___
3674 : Phospho-Myosin Light Chain 2 (Thr18/Ser19) Antibody
3671 : Phospho-Myosin Light Chain 2 (Ser19) Antibody
3674 : Phospho-Myosin Light Chain 2 (Thr18/Ser19) Antibody
3675 : Phospho-Myosin Light Chain 2 (Ser19) Mouse mAb
  mouse

 
S2 ______MSSKRAKAK
S3 _____MSSKRAKAKT
T10 SKRAKAKTTKKRPQR
T11 KRAKAKTTKKRPQRA
T19-p KKRPQRAtsNVFAMF
S20-p KRPQRAtsNVFAMFD
S29-p VFAMFDQsQIQEFKE
K51-ub NRDGFIDkEDLHDML
S115 ACFDEEASGFIHEDH
Y143 DEEVDEMYREAPIDk
K150-ub YREAPIDkkGNFNYV
K151-ub REAPIDkkGNFNYVE
Y156 DkkGNFNYVEFTRIL
K164 VEFTRILKHGAKDKD
K168 RILKHGAKDKDD___
3674 : Phospho-Myosin Light Chain 2 (Thr18/Ser19) Antibody
3671 : Phospho-Myosin Light Chain 2 (Ser19) Antibody
3674 : Phospho-Myosin Light Chain 2 (Thr18/Ser19) Antibody
3675 : Phospho-Myosin Light Chain 2 (Ser19) Mouse mAb
  rat

 
S2 ______MSSKRAKAK
S3 _____MSSKRAKAKT
T10 SKRAKAKTTKKRPQS
T11 KRAKAKTTKKRPQSA
T19-p KKRPQSAtsNVFAMF
S20-p KRPQSAtsNVFAMFD
S29 VFAMFDQSQIQEFKE
K51 NRDGFIDKEDLHDML
S115 ACFDEEASGFIHEDH
Y143 DEEVDEMYRERIDKK
K149 MYRERIDKKGNFNYV
K150 YRERIDKKGNFNYVE
Y155 DKKGNFNYVEFTRIL
K163 VEFTRILKHGAKDKD
K167 RILKHGAKDKDD___
3674 : Phospho-Myosin Light Chain 2 (Thr18/Ser19) Antibody
3671 : Phospho-Myosin Light Chain 2 (Ser19) Antibody
3674 : Phospho-Myosin Light Chain 2 (Thr18/Ser19) Antibody
3675 : Phospho-Myosin Light Chain 2 (Ser19) Mouse mAb
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