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MRLC1 (human)

Overview MRLC1 Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. Myosin is an hexamer of 2 heavy chains and 4 light chains. Smooth muscle tissues and in some, but not all, nonmuscle cells. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Contractile protein; Motility/polarity/chemotaxis Cellular Component: stress fiber; muscle myosin complex; Z disc; cytosol Molecular Function: structural constituent of muscle; calcium ion binding Biological Process: axon guidance; muscle contraction; regulation of muscle contraction Reference #:  P24844 (UniProtKB) Alt. Names/Synonyms: 20 kDa myosin light chain; LC20; MGC3505; MLC-2C; MLC2; MRLC1; MYL9; myosin regulatory light chain 1; Myosin regulatory light chain 2, smooth muscle isoform; Myosin regulatory light chain 9; Myosin regulatory light chain MRLC1; Myosin regulatory light polypeptide 9; Myosin RLC; myosin, light chain 9, regulatory; myosin, light polypeptide 9, regulatory; MYRL2 Gene Symbols: MYL9 Molecular weight: 19,827 Da Basal Isoelectric point: 4.8  Predict pI for various phosphorylation states CST Pathways:  Regulation of Actin Dynamics  |  TGF-ß Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MRLC1

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell adhesion, altered: S20‑p cell motility, altered: S20‑p cytoskeletal reorganization: S20‑p activation: S20‑p intracellular localization: S20‑p molecular association, regulation: S20‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
4	0		S2-p	______MssKRAKAK
4	0		S3-p	_____MssKRAKAKt
4	4		T10-p	sKRAKAKttKKRPQR
0	6		T11-p	KRAKAKttKKRPQRA
16	284		T19-p	KKRPQRAtsNVFAMF
30	302		S20-p	KRPQRAtsNVFAMFD
0	7		S29-p	VFAMFDQsQIQEFKE
0	4		K51-u	NRDGFIDkEDLHDML
0	1		Y143-p	DEEVDEMyREAPIDK
0	1		K150	yREAPIDKKGNFNyV
0	1		K151	REAPIDKKGNFNyVE
0	21		Y156-p	DKKGNFNyVEFTRIL
0	1		K164-u	VEFTRILkHGAkDKD
0	1		K168-a	RILkHGAkDKDD___

	mouse
S2	______MSSKRAKAK
S3	_____MSSKRAKAKT
T10	SKRAKAKTTKKRPQR
T11	KRAKAKTTKKRPQRA
T19-p	KKRPQRAtsNVFAMF
S20-p	KRPQRAtsNVFAMFD
S29-p	VFAMFDQsQIQEFKE
K51-u	NRDGFIDkEDLHDML
Y143	DEEVDEMYREAPIDk
K150-u	YREAPIDkkGNFNYV
K151-u	REAPIDkkGNFNYVE
Y156	DkkGNFNYVEFTRIL
K164	VEFTRILKHGAKDKD
K168	RILKHGAKDKDD___

	rat
S2	______MSSKRAKAK
S3	_____MSSKRAKAKT
T10	SKRAKAKTTKKRPQS
T11	KRAKAKTTKKRPQSA
T19-p	KKRPQSAtsNVFAMF
S20-p	KRPQSAtsNVFAMFD
S29	VFAMFDQSQIQEFKE
K51	NRDGFIDKEDLHDML
Y143	DEEVDEMYRERIDKK
K149	MYRERIDKKGNFNYV
K150	YRERIDKKGNFNYVE
Y155	DKKGNFNYVEFTRIL
K163	VEFTRILKHGAKDKD
K167	RILKHGAKDKDD___

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