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Protein Page:
IL1RAPL1 (human)

Overview
IL1RAPL1 May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons. Defects in IL1RAPL1 are the cause of mental retardation X-linked type 21 (MRX21). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Belongs to the interleukin-1 receptor family. 1 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Cellular Component: postsynaptic membrane; cell surface; axon; dendrite; cytoplasm; plasma membrane; integral to membrane
Molecular Function: voltage-gated calcium channel activity; protein binding; interleukin-1 binding; receptor binding
Biological Process: heterophilic cell adhesion; neuron differentiation; negative regulation of exocytosis; positive regulation of dendrite morphogenesis; signal transduction
Reference #:  Q9NZN1 (UniProtKB)
Alt. Names/Synonyms: IL-1-RAPL-1; IL-1RAPL-1; IL1R8; IL1RAPL; IL1RAPL-1; IL1RAPL1; interleukin 1 receptor accessory protein-like 1; interleukin 1 receptor-8; Interleukin-1 receptor accessory protein-like 1; IRPL1; mental retardation, X-linked 10; MRX10; MRX21; MRX34; Oligophrenin-4; OPHN4; Three immunoglobulin domain-containing IL-1 receptor-related 2; TIGIRR-2; X-linked interleukin-1 receptor accessory protein-like 1
Gene Symbols: IL1RAPL1
Molecular weight: 79,969 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
Select Structure to View Below

IL1RAPL1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T187 LWYKECRTKTWRPSI
0 1 T228-p GGFVVRRtTELTVTA
0 2 Y459 DLIPTGTYIEDVARC
0 1 T478-p KRLIIVMtPNYVVRR
0 3 Y615 RSTFHNTYHSQMRQK
0 1 S642 TGTLPLTSIGNQHTY
  mouse

 
T187-p LWYKECRtKAWRPSI
T228 GGFVVRRTTELTVTA
- gap
T477 KRLIIVMTPNYVVRR
Y614 RSTFHNTYHSQMRQK
S641 TGTLPLTSIGNQHTY
  rat

 
T187 LWYKECRTKTWRPSI
T228 GGFVVRRTTELTVTA
Y459-p DLIPTGTyIEDVARC
T478 KRLIIVMTPNYVVRR
Y615-p RSTFHNTyHSQMRQK
S642-p TGTLPLTsIGNQHTY
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