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ACLY (human)

Overview ACLY ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine. Homotetramer. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: EC 2.3.3.8; Lyase; Transferase; Carbohydrate Metabolism - citrate (TCA) cycle Cellular Component: mitochondrion; citrate lyase complex; cytoplasm; nucleolus; plasma membrane; cytosol; nucleus Molecular Function: ATP citrate synthase activity; metal ion binding; succinate-CoA ligase (ADP-forming) activity; cofactor binding; ATP binding Biological Process: ATP catabolic process; coenzyme A metabolic process; energy reserve metabolic process; positive regulation of cellular metabolic process; citrate metabolic process; triacylglycerol biosynthetic process; cellular carbohydrate metabolic process; cellular lipid metabolic process Reference #:  P53396 (UniProtKB) Alt. Names/Synonyms: ACL; ACLY; ATP citrate lyase; ATP-citrate (pro-S-)-lyase; ATP-citrate synthase; ATPCL; Citrate cleavage enzyme; CLATP Gene Symbols: ACLY Molecular weight: 120,839 Da Basal Isoelectric point: 6.95  Predict pI for various phosphorylation states CST Pathways:  Insulin Receptor Signaling  |  Warburg Effect Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ACLY 3MWD - A=1-425 B=487-820 (human) 3MWE - A=1-425 B=487-821 (human) 3PFF - A=1-817 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 3MWD 3MWE 3PFF  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	2		K12-u	AISEQTGkELLYKFI
0	2		K58-u	LSQNLVVkPDQLIkR
0	1		K64-u	VkPDQLIkRRGkLGL
0	2		K68-u	QLIkRRGkLGLVGVN
0	1		T77	GLVGVNLTLDGVkSW
0	1		K82-u	NLTLDGVkSWLkPRL
0	1		K86-a	DGVkSWLkPRLGQEA
0	3		K86-u	DGVkSWLkPRLGQEA
0	1		K97-u	GQEATVGkATGFLKN
0	11		Y131-p	YATREGDyVLFHHEG
0	3		K148-u	DVGDVDAkAQkLLVG
0	3		K151-u	DVDAkAQkLLVGVDE
0	1		K159	LLVGVDEKLNPEDIK
0	2		K230-u	ATADYICkVkWGDIE
0	1		K232-u	ADYICkVkWGDIEFP
0	2		Y247-p	PPFGREAyPEEAyIA
0	1		Y252-p	EAyPEEAyIADLDAk
0	2		K259-u	yIADLDAksGASLkL
0	1		S260-p	IADLDAksGASLkLT
0	1		S263	LDAksGASLkLTLLN
0	2		K265-u	AksGASLkLTLLNPk
0	3		K272-u	kLTLLNPkGRIWTMV
0	1		Y317-p	APSEQQTyDYAKTIL
0	1		Y364-p	IVRAIRDyQGPLkEH
0	1		K369-u	RDyQGPLkEHEVTIF
1	4		Y384-p	VRRGGPNyQEGLRVM
0	1		S442-p	ANFLLNAsGststPA
0	1		S444-p	FLLNAsGststPAPs
0	2		T445-p	LLNAsGststPAPsR
0	7		S446-p	LNAsGststPAPsRt
1	53		T447-p	NAsGststPAPsRtA
1	8		S451-p	ststPAPsRtAsFsE
0	10		T453-p	stPAPsRtAsFsEsR
4	137		S455-p	PAPsRtAsFsEsRAD
0	6		S457-p	PsRtAsFsEsRADEV
0	2		S459-p	RtAsFsEsRADEVAP
0	1		K468-u	ADEVAPAkKAkPAMP
0	3		K471-u	VAPAkKAkPAMPQDs
0	8		S478-p	kPAMPQDsVPsPRSL
0	39		S481-p	MPQDsVPsPRSLQGk
0	7		K488-u	sPRSLQGkSTTLFSR
0	1		K498-u	TLFSRHTkAIVWGMQ
0	1		T506	AIVWGMQTRAVQGML
0	3		Y531-p	PSVAAMVyPFTGDHk
0	1		T534	AAMVyPFTGDHkQKF
0	2		K538-u	yPFTGDHkQKFYWGH
0	1		K546-a	QKFYWGHkEILIPVF
0	3		K546-u	QKFYWGHkEILIPVF
0	3		K554-a	EILIPVFkNMADAMR
0	1		S574-p	DVLINFAsLRSAYDS
0	1		Y579	FAsLRSAYDSTMETM
0	4		Y588-p	STMETMNyAQIRTIA
0	1		K616	LIKKADQKGVTIIGP
0	1		K630-a	PATVGGIkPGCFkIG
0	1		K630	PATVGGIKPGCFkIG
0	2		K635-a	GIkPGCFkIGNtGGM
0	1		K635-u	GIkPGCFkIGNtGGM
0	1		T639-p	GCFkIGNtGGMLDNI
0	3		K650-u	LDNILASkLyRPGSV
0	2		Y652-p	NILASkLyRPGSVAY
0	3		S663-p	SVAYVSRsGGMSNEL
0	1		T677-p	LNNIISRtTDGVyEG
0	360		Y682-p	SRtTDGVyEGVAIGG
3	0		H760-p	SSEVQFGhAGACANQ
0	5		K780-u	VAKNQALkEAGVFVP
0	2		Y825	PPTVPMDYSWARELG
0	1		K836	RELGLIRKPAsFMTS
0	2		S839-p	GLIRKPAsFMTSICD
0	1		T860	IYAGMPITEVFKEEM
0	8		K918-u	IICARAGkDLVSSLT
0	1		T930-p	SLTSGLLtIGDRFGG
0	3		K944-u	GALDAAAkMFSkAFD
0	1		K948-a	AAAkMFSkAFDSGII
0	2		K948-u	AAAkMFSkAFDSGII
0	1		S952	MFSkAFDSGIIPMEF
0	1		K962-a	IPMEFVNkMkkEGkL
0	1		K962	IPMEFVNKMkkEGkL
0	1		K964-m1	MEFVNkMkkEGkLIM
0	1		K965-m1	EFVNkMkkEGkLIMG
0	2		K968-a	NkMkkEGkLIMGIGH
0	2		K978-a	MGIGHRVksINNPDM
0	1		K978	MGIGHRVKsINNPDM
0	2		S979-p	GIGHRVksINNPDMR
0	4		K991-u	DMRVQILkDYVRQHF
0	1		S1066	GIFVLGRSMGFIGHy
0	63		Y1073-p	SMGFIGHyLDQkRLk
0	7		K1077-a	IGHyLDQkRLkQGLy
0	3		K1077-u	IGHyLDQkRLkQGLy
0	3		K1080-u	yLDQkRLkQGLyRHP
0	1		Y1084-p	kRLkQGLyRHPWDDI
0	5		S1100-p	YVLPEHMsM______

	ACLY iso3
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-	gap
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S52	ANFLLNASGSTSTPA
S54	FLLNASGSTSTPAPS
T55	LLNASGSTSTPAPSR
S56	LNASGSTSTPAPSRT
T57	NASGSTSTPAPSRTA
S61	STSTPAPSRTASFSE
T63	STPAPSRTASFSESR
S65	PAPSRTASFSESRAD
S67	PSRTASFSESRADEV
S69	RTASFSESRADEVAP
K78	ADEVAPAKKAkPAMP
K81-u	VAPAKKAkPAMPQGk
-	gap
-	gap
K88-u	kPAMPQGkSTTLFSR
K98	TLFSRHTKAIVWGMQ
T106	AIVWGMQTRAVQGML
Y131	PSVAAMVYPFTGDHK
T134	AAMVYPFTGDHKQKF
K138	YPFTGDHKQKFYWGH
K146	QKFYWGHKEILIPVF
K146	QKFYWGHKEILIPVF
K154	EILIPVFKNMADAMR
S174	DVLINFASLRSAYDS
Y179	FASLRSAYDSTMETM
Y188	STMETMNYAQIRTIA
K216	LIKKADQKGVTIIGP
K230	PATVGGIKPGCFKIG
K230	PATVGGIKPGCFKIG
K235	GIKPGCFKIGNTGGM
K235	GIKPGCFKIGNTGGM
T239	GCFKIGNTGGMLDNI
K250	LDNILASKLYRPGSV
Y252	NILASKLYRPGSVAY
S263	SVAYVSRSGGMSNEL
T277	LNNIISRTTDGVYEG
Y282	SRTTDGVYEGVAIGG
H360	SSEVQFGHAGACANQ
K380	VAKNQALKEAGVFVP
Y425	PPTVPMDYSWARELG
K436	RELGLIRKPASFMTS
S439	GLIRKPASFMTSICD
T460	IYAGMPITEVFKEEM
K518	IICARAGKDLVSSLT
T530	SLTSGLLTIGDRFGG
K544	GALDAAAKMFSKAFD
K548	AAAKMFSKAFDSGII
K548	AAAKMFSKAFDSGII
S552	MFSKAFDSGIIPMEF
K562	IPMEFVNKMKKEGKL
K562	IPMEFVNKMKKEGKL
K564	MEFVNKMKKEGKLIM
K565	EFVNKMKKEGKLIMG
K568	NKMKKEGKLIMGIGH
K578	MGIGHRVKSINNPDM
K578	MGIGHRVKSINNPDM
S579	GIGHRVKSINNPDMR
K591	DMRVQILKDYVRQHF
S666	GIFVLGRSMGFIGHY
Y673	SMGFIGHYLDQKRLK
K677	IGHYLDQKRLKQGLY
K677	IGHYLDQKRLKQGLY
K680	YLDQKRLKQGLYRHP
Y684	KRLKQGLYRHPWDDI
S700	YVLPEHMSM______

	mouse ► Hide Isoforms
K12-u	AISEQTGkELLYKYI
K58	LSQSLVVKPDQLIKR
K64	VKPDQLIKRRGkLGL
K68-u	QLIKRRGkLGLVGVN
S77-p	GLVGVNLsLDGVKSW
K82	NLsLDGVKSWLKPRL
K86	DGVKSWLKPRLGHEA
K86	DGVKSWLKPRLGHEA
K97	GHEATVGKAKGFLKN
Y131	YATREGDYVLFHHEG
K148-u	DVGDVDAkAQkLLVG
K151-u	DVDAkAQkLLVGVDE
K159-u	LLVGVDEkLNTEDIK
K230-u	ATADYICkVKWGDIE
K232	ADYICkVKWGDIEFP
Y247-p	PPFGREAyPEEAyIA
Y252-p	EAyPEEAyIADLDAk
K259-u	yIADLDAksGAsLkL
S260-p	IADLDAksGAsLkLT
S263-p	LDAksGAsLkLTLLN
K265-u	AksGAsLkLTLLNPk
K272-u	kLTLLNPkGRIWTMV
Y317	APSEQQTYDYAKTIL
Y364	IVRAIRDYQGPLKEH
K369	RDYQGPLKEHEVTIF
Y384-p	VRRGGPNyQEGLRVM
S442	ANFLLNASGSTStPA
S444	FLLNASGSTStPAPS
T445	LLNASGSTStPAPSR
S446	LNASGSTStPAPSRt
T447-p	NASGSTStPAPSRtA
S451	STStPAPSRtAsFsE
T453-p	StPAPSRtAsFsESR
S455-p	PAPSRtAsFsESRAD
S457-p	PSRtAsFsESRADEV
S459	RtAsFsESRADEVAP
K468	ADEVAPAKKAkPAMP
K471-u	VAPAKKAkPAMPQGk
-	gap
-	gap
K478-u	kPAMPQGkSATLFSR
K488	TLFSRHTKAIVWGMQ
T496-p	AIVWGMQtRAVQGML
Y521-p	PSVAAMVyPFtGDHk
T524-p	AAMVyPFtGDHkQKF
K528-u	yPFtGDHkQKFYWGH
K536	QKFYWGHKEILIPVF
K536-u	QKFYWGHkEILIPVF
K544-a	EILIPVFkNMADAMK
S564	DVLINFASLRSAYDS
Y569	FASLRSAYDSTMETM
Y578	STMETMNYAQIRTIA
K606-u	LIKKADQkGVTIIGP
K620	PATVGGIKPGCFKIG
K620-u	PATVGGIkPGCFKIG
K625	GIkPGCFKIGNTGGM
K625	GIkPGCFKIGNTGGM
T629	GCFKIGNTGGMLDNI
K640-u	LDNILASkLYRPGSV
Y642	NILASkLYRPGSVAY
S653-p	SVAYVSRsGGMSNEL
T667	LNNIISRTTDGVyEG
Y672-p	SRTTDGVyEGVAIGG
H750-p	SSEVQFGhAGACANQ
K770-u	VAKNQALkEAGVFVP
Y815-p	PPTVPMDySWARELG
K826-u	RELGLIRkPAsFMTS
S829-p	GLIRkPAsFMTSICD
T850-p	IYAGMPItEVFKEEM
K908-u	IICARAGkDLVSSLT
T920	SLTSGLLTIGDRFGG
K934-u	GALDAAAkMFSkAFD
K938	AAAkMFSKAFDsGII
K938-u	AAAkMFSkAFDsGII
S942-p	MFSkAFDsGIIPMEF
K952	IPMEFVNKMKKEGkL
K952-u	IPMEFVNkMKKEGkL
K954	MEFVNkMKKEGkLIM
K955	EFVNkMKKEGkLIMG
K958-a	NkMKKEGkLIMGIGH
K968-a	MGIGHRVksINNPDM
K968-u	MGIGHRVksINNPDM
S969-p	GIGHRVksINNPDMR
K981-u	DMRVQILkDFVKQHF
S1056-p	GIFVLGRsMGFIGHY
Y1063	sMGFIGHYLDQkRLk
K1067-a	IGHYLDQkRLkQGLY
K1067-u	IGHYLDQkRLkQGLY
K1070-u	YLDQkRLkQGLYRHP
Y1074	kRLkQGLYRHPWDDI
S1090-p	YVLPEHMsM______

	ACLY iso2
K12	AISEQTGKELLYKYI
K58	LSQSLVVKPDQLIKR
K64	VKPDQLIKRRGKLGL
K68	QLIKRRGKLGLVGVN
S77	GLVGVNLSLDGVKSW
K82	NLSLDGVKSWLKPRL
K86	DGVKSWLKPRLGHEA
K86	DGVKSWLKPRLGHEA
K97	GHEATVGKAKGFLKN
Y131	YATREGDYVLFHHEG
K148	DVGDVDAKAQKLLVG
K151	DVDAKAQKLLVGVDE
K159	LLVGVDEKLNTEDIK
K230	ATADYICKVKWGDIE
K232	ADYICKVKWGDIEFP
Y247	PPFGREAYPEEAYIA
Y252	EAYPEEAYIADLDAK
K259	YIADLDAKSGASLKL
S260	IADLDAKSGASLKLT
S263	LDAKSGASLKLTLLN
K265	AKSGASLKLTLLNPK
K272	KLTLLNPKGRIWTMV
Y317	APSEQQTYDYAKTIL
Y364	IVRAIRDYQGPLKEH
K369	RDYQGPLKEHEVTIF
Y384	VRRGGPNYQEGLRVM
S442	ANFLLNASGSTSTPA
S444	FLLNASGSTSTPAPS
T445	LLNASGSTSTPAPSR
S446	LNASGSTSTPAPSRT
T447	NASGSTSTPAPSRTA
S451	STSTPAPSRTASFSE
T453	STPAPSRTASFSESR
S455	PAPSRTASFSESRAD
S457	PSRTASFSESRADEV
S459	RTASFSESRADEVAP
K468	ADEVAPAKKAKPAMP
K471	VAPAKKAKPAMPQDS
S478	KPAMPQDSVPsPRSL
S481-p	MPQDSVPsPRSLQGk
K488-u	sPRSLQGkSATLFSR
K498	TLFSRHTKAIVWGMQ
T506	AIVWGMQTRAVQGML
Y531	PSVAAMVYPFTGDHK
T534	AAMVYPFTGDHKQKF
K538	YPFTGDHKQKFYWGH
K546	QKFYWGHKEILIPVF
K546	QKFYWGHKEILIPVF
K554	EILIPVFKNMADAMK
S574	DVLINFASLRSAYDS
Y579	FASLRSAYDSTMETM
Y588	STMETMNYAQIRTIA
K616	LIKKADQKGVTIIGP
K630	PATVGGIKPGCFKIG
K630	PATVGGIKPGCFKIG
K635	GIKPGCFKIGNTGGM
K635	GIKPGCFKIGNTGGM
T639	GCFKIGNTGGMLDNI
K650	LDNILASKLYRPGSV
Y652	NILASKLYRPGSVAY
S663	SVAYVSRSGGMSNEL
T677	LNNIISRTTDGVYEG
Y682	SRTTDGVYEGVAIGG
H760	SSEVQFGHAGACANQ
K780	VAKNQALKEAGVFVP
Y825	PPTVPMDYSWARELG
K836	RELGLIRKPASFMTS
S839	GLIRKPASFMTSICD
T860	IYAGMPITEVFKEEM
K918	IICARAGKDLVSSLT
T930	SLTSGLLTIGDRFGG
K944	GALDAAAKMFSKAFD
K948	AAAKMFSKAFDSGII
K948	AAAKMFSKAFDSGII
S952	MFSKAFDSGIIPMEF
K962	IPMEFVNKMKKEGKL
K962	IPMEFVNKMKKEGKL
K964	MEFVNKMKKEGKLIM
K965	EFVNKMKKEGKLIMG
K968	NKMKKEGKLIMGIGH
K978	MGIGHRVKSINNPDM
K978	MGIGHRVKSINNPDM
S979	GIGHRVKSINNPDMR
K991	DMRVQILKDFVKQHF
S1066	GIFVLGRSMGFIGHY
Y1073	SMGFIGHYLDQKRLK
K1077	IGHYLDQKRLKQGLY
K1077	IGHYLDQKRLKQGLY
K1080	YLDQKRLKQGLYRHP
Y1084	KRLKQGLYRHPWDDI
S1100	YVLPEHMSM______

	ACLY iso3
K12	AISEQTGKELLYKYI
K58	LSQSLVVKPDQLIKR
K64	VKPDQLIKRRGKLGL
K68	QLIKRRGKLGLVGVN
S77	GLVGVNLSLDGVKSW
K82	NLSLDGVKSWLKPRL
K86	DGVKSWLKPRLGHEA
K86	DGVKSWLKPRLGHEA
K97	GHEATVGKAKGFLKN
Y131	YATREGDYVLFHHEG
K148	DVGDVDAKAQKLLVG
K151	DVDAKAQKLLVGVDE
K159	LLVGVDEKLNTEDIK
K230	ATADYICKVKWGDIE
K232	ADYICKVKWGDIEFP
Y247	PPFGREAYPEEAYIA
Y252	EAYPEEAYIADLDAK
K259	YIADLDAKSGASLKL
S260	IADLDAKSGASLKLT
S263	LDAKSGASLKLTLLN
K265	AKSGASLKLTLLNPK
K272	KLTLLNPKGRIWTMV
Y317	APSEQQTYDYAKTIL
Y364	IVRAIRDYQGPLKEH
K369	RDYQGPLKEHEVTIF
Y384	VRRGGPNYQEGLRVM
S442	ANFLLNASGSTSTPA
S444	FLLNASGSTSTPAPS
T445	LLNASGSTSTPAPSR
S446	LNASGSTSTPAPSRT
T447	NASGSTSTPAPSRTA
S451	STSTPAPSRTASFSE
T453	STPAPSRTASFSESR
S455	PAPSRTASFSESRAD
S457	PSRTASFSESRADEV
S459	RTASFSESRADEVAP
K468	ADEVAPAKKAKPAMP
K471	VAPAKKAKPAMPQDS
S478	KPAMPQDSVPsPRSL
S481-p	MPQDSVPsPRSLQGH
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	rat
K12	AISEQTGKELLYKYI
K58	LSQSLVVKPDQLIKR
K64	VKPDQLIKRRGKLGL
K68	QLIKRRGKLGLVGVN
S77	GLVGVNLSLDGVKSW
K82	NLSLDGVKSWLkPRL
K86	DGVKSWLKPRLGHEA
K86-u	DGVKSWLkPRLGHEA
K97	GHEATVGKAKGFLKN
Y131	YATREGDYVLFHHEG
K148	DVGDVDTKAQKLLVG
K151	DVDTKAQKLLVGVDE
K159	LLVGVDEKLNAEDIK
K230	ATADYICKVKWGDIE
K232	ADYICKVKWGDIEFP
Y247	PPFGREAYPEEAYIA
Y252	EAYPEEAYIADLDAK
K259	YIADLDAKSGASLKL
S260	IADLDAKSGASLKLT
S263	LDAKSGASLKLTLLN
K265	AKSGASLKLTLLNPK
K272	KLTLLNPKGRIWTMV
Y317	APSEQQTYDYAKTIL
Y364	IVRAIRDYQGSLKEH
K369	RDYQGSLKEHEVTIF
Y384-p	VRRGGPNyQEGLRVM
S441	ANFLLNASGSTStPA
S443	FLLNASGSTStPAPs
T444	LLNASGSTStPAPsR
S445	LNASGSTStPAPsRt
T446-p	NASGSTStPAPsRtA
S450-p	STStPAPsRtAsFSE
T452-p	StPAPsRtAsFSESR
S454-p	PAPsRtAsFSESRAD
S456	PsRtAsFSESRADEV
S458	RtAsFSESRADEVAP
K467	ADEVAPAKKAKPAMP
K470	VAPAKKAKPAMPQDs
S477-p	KPAMPQDsVPsPRSL
S480-p	MPQDsVPsPRSLQGK
K487	sPRSLQGKSATLFSR
K497	TLFSRHTKAIVWGMQ
T505	AIVWGMQTRAVQGML
Y530	PSVAAMVYPFTGDHK
T533	AAMVYPFTGDHKQKF
K537	YPFTGDHKQKFYWGH
K545	QKFYWGHKEILIPVF
K545	QKFYWGHKEILIPVF
K553-a	EILIPVFkNMADAMK
S573	DVLINFASLRSAyDS
Y578-p	FASLRSAyDSTMETM
Y587	STMETMNYAQIRTIA
K615	LIKKADQKGVTIIGP
K629	PATVGGIKPGCFKIG
K629	PATVGGIKPGCFKIG
K634	GIKPGCFKIGNTGGM
K634	GIKPGCFKIGNTGGM
T638	GCFKIGNTGGMLDNI
K649	LDNILASKLYRPGSV
Y651	NILASKLYRPGSVAY
S662	SVAYVSRSGGMSNEL
T676	LNNIISRTTDGVyEG
Y681-p	SRTTDGVyEGVAIGG
H759-p	SSEVQFGhAGACANQ
K779	VAKNQALKEAGVFVP
Y824	PPTVPMDYSWARELG
K835	RELGLIRKPASFMTS
S838	GLIRKPASFMTSICD
T859	IYAGMPITEVFKEEM
K917	IICARAGKDLVSSLT
T929	SLTSGLLTIGDRFGG
K943	GALDAAAKMFSKAFD
K947	AAAKMFSKAFDSGII
K947	AAAKMFSKAFDSGII
S951	MFSKAFDSGIIPMEF
K961	IPMEFVNKMKKEGKL
K961	IPMEFVNKMKKEGKL
K963	MEFVNKMKKEGKLIM
K964	EFVNKMKKEGKLIMG
K967	NKMKKEGKLIMGIGH
K977	MGIGHRVKSINNPDM
K977	MGIGHRVKSINNPDM
S978	GIGHRVKSINNPDMR
K990	DMRVQILKDFVKQHF
S1065	GVFVLGRSMGFIGHY
Y1072	SMGFIGHYLDQKRLK
K1076	IGHYLDQKRLKQGLY
K1076	IGHYLDQKRLKQGLY
K1079	YLDQKRLKQGLYRHP
Y1083	KRLKQGLYRHPWDDI
S1099	YVLPEHMSM______

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