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CD40LG (human)

Overview CD40LG Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1); also known as X-linked hyper IgM syndrome (XHIM). HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence. Belongs to the tumor necrosis factor family. Note: This description may include information from UniProtKB. Protein type: Cell adhesion; Membrane protein, integral Cellular Component: extracellular space; integral to plasma membrane; plasma membrane; integral to membrane; external side of plasma membrane Molecular Function: cytokine activity; CD40 receptor binding; tumor necrosis factor receptor binding Biological Process: B cell proliferation; platelet activation; regulation of immune response; positive regulation of interleukin-12 production; isotype switching; positive regulation of immune response to tumor cell; positive regulation of interleukin-10 production; leukocyte adhesion; positive regulation of interferon-gamma production; positive regulation of MHC class II biosynthetic process; B cell differentiation; immunoglobulin secretion; positive regulation of B cell proliferation; inflammatory response; regulation of immunoglobulin secretion; negative regulation of apoptosis Reference #:  P29965 (UniProtKB) Alt. Names/Synonyms: CD154; CD40 antigen ligand; CD40 ligand; CD40 ligand, membrane form; CD40 ligand, soluble form; CD40-L; CD40L; CD40LG; gp39; hCD40L; HIGM1; IGM; IMD3; T-B cell-activating molecule; T-BAM; T-cell antigen Gp39; TNF-related activation protein; TNFSF5; TRAP; tumor necrosis factor (ligand) superfamily member 5; Tumor necrosis factor ligand superfamily member 5 Gene Symbols: CD40LG Molecular weight: 29,274 Da Basal Isoelectric point: 8.53  Predict pI for various phosphorylation states

Select Structure to View Below CD40LG 1ALY - A=116-261 (human) 1I9R - A/B/C=116-261 (human) 3LKJ - A/C/B=121-261 (human) 3QD6 - F/A/D/C/E/B=116-261 (human) 1CDA - A/B/C=115-260 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1ALY 1I9R 3LKJ 3QD6  |  Phospho3D  |  DISEASE 300386 308230  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		T4-p	____MIEtyNQTSPR
0	37		Y5-p	___MIEtyNQTSPRS
0	1		N6	__MIEtyNQTSPRSA
0	1		S78	RCNTGERSLSLLNCE
0	1		S80	NTGERSLSLLNCEEI
0	1		N150	KGYYTMSNNLVTLEN

	mouse
T4-p	____MIEtYsQPSPR
Y5	___MIEtYsQPSPRS
S6-p	__MIEtYsQPSPRSV
S78-p	RCNKGEGsLsLLNCE
S80-p	NKGEGsLsLLNCEEM
S149-p	KGYYTMKsNLVMLEN

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