Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
CD40LG (human)

Overview
CD40LG Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1); also known as X-linked hyper IgM syndrome (XHIM). HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence. Belongs to the tumor necrosis factor family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell adhesion
Cellular Component: extracellular space; integral to plasma membrane; plasma membrane; integral to membrane; external side of plasma membrane
Molecular Function: cytokine activity; CD40 receptor binding; tumor necrosis factor receptor binding
Biological Process: B cell proliferation; platelet activation; regulation of immune response; leukocyte adhesion; positive regulation of interleukin-12 production; B cell differentiation; immunoglobulin secretion; isotype switching; inflammatory response; regulation of immunoglobulin secretion; negative regulation of apoptosis
Reference #:  P29965 (UniProtKB)
Alt. Names/Synonyms: CD154; CD40 antigen ligand; CD40 ligand; CD40 ligand, membrane form; CD40 ligand, soluble form; CD40-L; CD40L; CD40LG; gp39; hCD40L; HIGM1; IGM; IMD3; T-B cell-activating molecule; T-BAM; T-cell antigen Gp39; TNF-related activation protein; TNFSF5; TRAP; tumor necrosis factor (ligand) superfamily member 5; Tumor necrosis factor ligand superfamily member 5
Gene Symbols: CD40LG
Molecular weight: 29,274 Da
Basal Isoelectric point: 8.53  Predict pI for various phosphorylation states
Select Structure to View Below

CD40LG

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 T4-p ____MIEtyNQTSPR
0 38 Y5-p ___MIEtyNQTSPRS
0 1 N6 __MIEtyNQTSPRSA
0 1 S78 RCNTGERSLSLLNCE
0 1 S80 NTGERSLSLLNCEEI
0 1 N150 KGYYTMSNNLVTLEN
  mouse

 
T4-p ____MIEtYsQPSPR
Y5 ___MIEtYsQPSPRS
S6-p __MIEtYsQPSPRSV
S78-p RCNKGEGsLsLLNCE
S80-p NKGEGsLsLLNCEEM
S149-p KGYYTMKsNLVMLEN
  rat

 
T4 ____MIETYSQPSPR
Y5 ___MIETYSQPSPRS
S6 __MIETYSQPSPRSV
S78 RCNKGEGSLSLLNCE
S80 NKGEGSLSLLNCEEM
S149 KGYYTMKSNLVVLEN
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.