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Protein Page:
CDK5R2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CDK5R2 Activator of CDK5/TPKII. Heterodimer of a catalytic subunit and a regulatory subunit. Brain and neuron specific. Belongs to the cyclin-dependent kinase 5 activator family. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, regulatory subunit
Cellular Component: cyclin-dependent protein kinase 5 activator complex; cytoplasm; plasma membrane
Molecular Function: cyclin-dependent protein kinase 5 activator activity; lipid binding
Biological Process: positive regulation of calcium ion-dependent exocytosis; superior olivary nucleus maturation; hippocampus development; neuron migration; cerebellum development; regulation of cyclin-dependent protein kinase activity; layer formation in the cerebral cortex
Reference #:  Q13319 (UniProtKB)
Alt. Names/Synonyms: CD5R2; CDK5 activator 2; CDK5R2; Cyclin-dependent kinase 5 activator 2; cyclin-dependent kinase 5 activator isoform p39i; Cyclin-dependent kinase 5 regulatory subunit 2; cyclin-dependent kinase 5, regulatory subunit 2 (p39); NCK5AI; neuronal CDK5 activator isoform; p39; p39I; p39nck5ai
Gene Symbols: CDK5R2
Molecular weight: 38,705 Da
Basal Isoelectric point: 9.76  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CDK5R2

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S8‑p, T84‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 1 S8-p MGTVLSLsPASSAKG
0 7 Y39 GDEALGGYGAPPVGK
0 2 K67-a LISALTWkRLVAASA
1 3 T84-p KKGSKKVtPKPASTG
0 1 S89 KVtPKPASTGPDPLV
1 1 S173-p APPVPGGsPRRVIVQ
  mouse

 
S8 MGTVLSLSPASSAKG
Y39 GDEALGGYGAPPAGK
K67 LISALTWKRLVAASA
T84-p KKGSKKVtPKPAsTG
S89-p KVtPKPAsTGPDPLV
S173 APPAPGGSPRRVIVQ
  rat

 
S8 MGTVLSLSPASSAKG
Y39-p GDEALGGyGAPPAGK
K67 LISALTWKRLVAASA
T84 KKGSKKVTPKPASTG
S89 KVTPKPASTGPDPLV
S173 APPAPGGSPRRVIVQ
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