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CDK5R2 (human)

Overview CDK5R2 Activator of CDK5/TPKII. Heterodimer of a catalytic subunit and a regulatory subunit. Brain and neuron specific. Belongs to the cyclin-dependent kinase 5 activator family. Note: This description may include information from UniProtKB. Protein type: Protein kinase, regulatory subunit; Kinase, protein Cellular Component: cyclin-dependent protein kinase 5 activator complex; cytoplasm; plasma membrane Molecular Function: cyclin-dependent protein kinase 5 activator activity; lipid binding Biological Process: positive regulation of calcium ion-dependent exocytosis; superior olivary nucleus maturation; hippocampus development; neuron migration; cerebellum development; regulation of cyclin-dependent protein kinase activity; layer formation in the cerebral cortex Reference #:  Q13319 (UniProtKB) Alt. Names/Synonyms: CD5R2; CDK5 activator 2; CDK5R2; Cyclin-dependent kinase 5 activator 2; cyclin-dependent kinase 5 activator isoform p39i; Cyclin-dependent kinase 5 regulatory subunit 2; cyclin-dependent kinase 5, regulatory subunit 2 (p39); NCK5AI; neuronal CDK5 activator isoform; p39; p39I; p39nck5ai Gene Symbols: CDK5R2 Molecular weight: 38,705 Da Basal Isoelectric point: 9.76  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CDK5R2

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	Sites Implicated In
intracellular localization: S8‑p, T84‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	1		S8-p	MGTVLSLsPASSAKG
0	7		Y39	GDEALGGYGAPPVGK
0	2		K67-a	LISALTWkRLVAASA
1	3		T84-p	KKGSKKVtPKPASTG
0	1		S89	KVtPKPASTGPDPLV
1	1		S173-p	APPVPGGsPRRVIVQ
0	1		T319	NADPHFFTQVFQDLK

	mouse
S8	MGTVLSLSPASSAKG
Y39	GDEALGGYGAPPAGK
K67	LISALTWKRLVAASA
T84-p	KKGSKKVtPKPAsTG
S89-p	KVtPKPAsTGPDPLV
S173	APPAPGGSPRRVIVQ
T319	NADPHFFTQVFQDLK

	rat
S8	MGTVLSLSPASSAKG
Y39-p	GDEALGGyGAPPAGK
K67	LISALTWKRLVAASA
T84	KKGSKKVTPKPASTG
S89	KVTPKPASTGPDPLV
S173	APPAPGGSPRRVIVQ
T319-p	NADPHFFtQVFQDLK

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