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ITGA5 (human)

Overview ITGA5 Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with RAB21 and COMP. Interacts with HIV- 1 Tat. Belongs to the integrin alpha chain family. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion Cellular Component: ruffle; focal adhesion; plasma membrane; intercellular junction; integrin complex; external side of plasma membrane Molecular Function: integrin binding; protein binding; vascular endothelial growth factor receptor 2 binding; metal ion binding; platelet-derived growth factor receptor binding Biological Process: integrin-mediated signaling pathway; axon guidance; positive regulation of vascular endothelial growth factor receptor signaling pathway; memory; heterophilic cell adhesion; leukocyte adhesion; positive regulation of peptidyl-tyrosine phosphorylation; virus-host interaction; cell-cell adhesion mediated by integrin; cell-substrate junction assembly; angiogenesis; cell adhesion; blood coagulation; leukocyte migration; wound healing, spreading of epidermal cells Reference #:  P08648 (UniProtKB) Alt. Names/Synonyms: CD49 antigen-like family member E; CD49e; Fibronectin receptor subunit alpha; fibronectin receptor, alpha subunit; FNRA; Integrin alpha-5; Integrin alpha-5 heavy chain; Integrin alpha-5 light chain; Integrin alpha-F; integrin, alpha 5 (fibronectin receptor, alpha polypeptide); ITA5; ITGA5; very late activation protein 5, alpha subunit; VLA-5; VLA5A Gene Symbols: ITGA5 Molecular weight: 114,536 Da Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states CST Pathways:  GPCRs Signaling to MAPK/Erk  |  MAPK/Erk in Growth and Differentiation  |  PI3K/Akt Signaling  |  Regulation of Actin Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ITGA5 3VI3 - A/C=42-664 (human) 3VI4 - A/C=42-664 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 3VI3 3VI4  |  DISEASE  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		S127-p	LLESSLSssEGEEPV
0	2		S128-p	LESSLSssEGEEPVE
0	1		K137-u	GEEPVEYkSLQWFGA
0	1		S394-p	DEFGRFGssLTPLGD
0	1		S395-p	EFGRFGssLTPLGDL
0	1		S595-p	KIYLRNEsEFRDKLS
0	1		S742-p	NPMKAGAsLWGGLRF
0	2		S887-p	LELDPEGsLHHQQKR
0	1		Y1032	FFKRSLPYGTAMEKA
0	1		K1038	PYGTAMEKAQLkPPA
0	1		K1042-u	AMEKAQLkPPATSDA

	mouse
S130	ILESSLYSAKGEEPV
A131	LESSLYSAKGEEPVE
K140	GEEPVEYKSLQWFGA
S397	DEFSRFGSSLTPLGD
S398	EFSRFGSSLTPLGDL
S598-p	KIYLRNEsEFRDKLS
S745	NPMKAGTSLWGGLRF
S891	LELDPETSPHHLQKR
Y1036-p	FFKRSLPyGTAMEkA
K1042-u	PyGTAMEkAQLKPPA
K1046	AMEkAQLKPPATSDA

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