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Protein Page:
ITGA5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ITGA5 Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with RAB21 and COMP. Interacts with HIV- 1 Tat. Belongs to the integrin alpha chain family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis
Cellular Component: ruffle; focal adhesion; cytoplasm; plasma membrane; synapse; intercellular junction; integrin complex; external side of plasma membrane
Molecular Function: integrin binding; protein binding; vascular endothelial growth factor receptor 2 binding; metal ion binding; platelet-derived growth factor receptor binding; epidermal growth factor receptor binding
Biological Process: integrin-mediated signaling pathway; axon guidance; extracellular matrix organization and biogenesis; viral reproduction; cell-substrate adhesion; positive regulation of vascular endothelial growth factor receptor signaling pathway; memory; heterophilic cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; leukocyte adhesion; cell-cell adhesion mediated by integrin; cell-substrate junction assembly; angiogenesis; blood coagulation; cell adhesion; leukocyte migration; positive regulation of cell migration; wound healing, spreading of epidermal cells
Reference #:  P08648 (UniProtKB)
Alt. Names/Synonyms: CD49 antigen-like family member E; CD49e; Fibronectin receptor subunit alpha; fibronectin receptor, alpha subunit; FNRA; Integrin alpha-5; Integrin alpha-5 heavy chain; Integrin alpha-5 light chain; Integrin alpha-F; integrin, alpha 5 (fibronectin receptor, alpha polypeptide); ITA5; ITGA5; very late activation protein 5, alpha subunit; VLA-5; VLA5A
Gene Symbols: ITGA5
Molecular weight: 114,536 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ITGA5

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 S127-p LLESSLSssEGEEPV
0 4 S128-p LESSLSssEGEEPVE
0 1 K137-ub GEEPVEYkSLQWFGA
0 1 S394-p DEFGRFGssLTPLGD
0 1 S395-p EFGRFGssLTPLGDL
0 1 S595 KIYLRNESEFRDKLS
0 1 S742-p NPMKAGAsLWGGLRF
0 2 S887-p LELDPEGsLHHQQKR
0 1 Y1032 FFKRSLPYGTAMEKA
0 1 K1038 PYGTAMEKAQLkPPA
0 1 K1042-ub AMEKAQLkPPATSDA
  mouse

 
S130 ILESSLYSAKGEEPV
A131 LESSLYSAKGEEPVE
K140 GEEPVEYKSLQWFGA
S397 DEFSRFGSSLTPLGD
S398 EFSRFGSSLTPLGDL
S598-p KIYLRNEsEFRDKLS
S745 NPMKAGTSLWGGLRF
S891 LELDPETSPHHLQKR
Y1036-p FFKRSLPyGTAMEkA
K1042-ub PyGTAMEkAQLKPPA
K1046 AMEkAQLKPPATSDA
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