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Protein Page:
TAF1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TAF1 Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA- binding activity. Essential for progression of the G1 phase of the cell cycle. Defects in TAF1 are the cause of dystonia type 3 (DYT3); also called X-linked dystonia-parkinsonism (XDP). DYT3 is a X-linked dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT3 is characterized by severe progressive torsion dystonia followed by parkinsonism. Its prevalence is high in the Philippines. DYT3 has a well-defined pathology of extensive neuronal loss and mosaic gliosis in the striatum (caudate nucleus and putamen) which appears to resemble that in Huntington disease. Belongs to the TAF1 family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Kinase, protein; DNA binding protein; Transcription, coactivator/corepressor; Protein kinase, atypical; Protein kinase, Ser/Thr (non-receptor); ATYPICAL group; TAF1 family
Cellular Component: nucleoplasm; transcription factor TFIID complex; nucleolus; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; histone acetyltransferase activity; p53 binding; TATA-binding protein binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor binding; ATP binding
Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; peptidyl-serine phosphorylation; viral reproduction; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein amino acid autophosphorylation; RNA elongation from RNA polymerase II promoter; transcription initiation; peptidyl-threonine phosphorylation; gene expression; positive regulation of transcription from RNA polymerase II promoter; histone acetylation; transcriptional preinitiation complex assembly; response to DNA damage stimulus; G2/M-specific transcription in mitotic cell cycle
Reference #:  P21675 (UniProtKB)
Alt. Names/Synonyms: BA2R; CCG1; CCGS; Cell cycle gene 1 protein; cell cycle, G1 phase defect; complementation of cell cycle block, G1-to-S; DYT3; DYT3/TAF1; KAT4; N-TAF1; NSCL2; OF; p250; TAF(II)250; TAF1; TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa; TAF2A; TAFII-250; TAFII250; TBP-associated factor 250 kDa; transcription factor TFIID p250 polypeptide; Transcription initiation factor TFIID 250 kDa subunit; Transcription initiation factor TFIID subunit 1; XDP
Gene Symbols: TAF1
Molecular weight: 212,677 Da
Basal Isoelectric point: 4.97  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TAF1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K170 PGPMKKDKDQDSITG
0 1 T198-p EMGPQEAtQAEsEDG
0 1 S202-p QEAtQAEsEDGKLTL
0 2 S307-p PPPEQCLsDDEITMM
0 1 Y343-p PRVAEWRyGPARLWy
0 1 Y350-p yGPARLWyDMLGVPE
0 1 Y364-p EDGSGFDyGFKLRKT
0 2 T442-p GWLPSSMtRNAMAYN
0 1 S522 DEKEEATSNsPSKES
0 2 S524-p KEEATSNsPSKESKK
0 1 S526 EATSNsPSKESKKES
0 2 K701-ub VGMATKIkNYYkRKP
0 21 K705-ac TKIkNYYkRKPGKDP
0 1 K705-ub TKIkNYYkRKPGKDP
0 1 Y888-p SPEQCCAyySMIAAE
0 1 Y889-p PEQCCAyySMIAAEQ
0 2 S1138-p RMLLAAGsAASGNNH
0 1 T1150 NNHRDDDTAsVTsLN
0 4 S1152-p HRDDDTAsVTsLNsS
0 1 T1154 DDDTAsVTsLNsSAT
0 6 S1155-p DDTAsVTsLNsSATG
0 1 S1158-p AsVTsLNsSATGRCL
0 2 K1244-ac NQEKEKLkGPPEKKP
0 1 T1306-p QEEELEKtVIHNDNE
0 1 K1347-ac SLVLKFPkQQLPPKk
0 1 K1353 PkQQLPPKkKRRVGt
0 1 K1354-ac kQQLPPKkKRRVGtT
0 1 T1360-p KkKRRVGtTVHCDyL
0 1 Y1366-p GtTVHCDyLNRPHKS
0 1 T1379-p KSIHRRRtDPMVtLS
0 1 T1384-p RRtDPMVtLSSILEs
0 2 S1391-p tLSSILEsIINDMRD
0 1 S1456 LELIVKNSATYNGPK
0 2 Y1541-p KKFVPDYyKVIVNPM
0 1 K1555 MDLETIRKNISKHKY
0 1 K1559 TIRKNISKHKYQSRE
0 1 K1561 RKNISKHKYQSRESF
0 1 T1643-p PMTPGPYtPQPPDLY
0 2 S1669-p ASVFQDEsNMsVLDI
0 2 S1672-p FQDEsNMsVLDIPsA
0 2 S1678-p MsVLDIPsAtPEKQV
0 5 T1680-p VLDIPsAtPEKQVTQ
0 1 - gap
0 3 S1778 MDMENEESMMSYEGD
0 4 S1781 ENEESMMSYEGDGGE
0 1 Y1782 NEESMMSYEGDGGEA
0 5 S1796 ASHGLEDSNIsYGsY
0 11 S1799-p GLEDSNIsYGsYEEP
0 4 Y1800 LEDSNIsYGsYEEPD
0 9 S1802-p DSNIsYGsYEEPDPK
0 3 Y1803 SNIsYGsYEEPDPKS
0 2 S1826-p SIGGYEVsEEEEDEE
  TAF1 iso2  
K170-ac PGPMKKDkDQDSITG
T219 EMGPQEATQAESEDG
S223 QEATQAESEDGKLTL
S328 PPPEQCLSDDEITMM
Y364 PRVAEWRYGPARLWY
Y371 YGPARLWYDMLGVPE
Y385 EDGSGFDYGFKLRKT
T463 GWLPSSMTRNAMAYN
S543 DEKEEATSNSPSKES
S545 KEEATSNSPSKESKK
S547 EATSNSPSKESKKES
K722 VGMATKIKNYYkRKP
K726-ac TKIKNYYkRKPGKDP
K726 TKIKNYYKRKPGKDP
Y909 SPEQCCAYYSMIAAE
Y910 PEQCCAYYSMIAAEQ
S1159 RMLLAAGSAASGNNH
T1171 NNHRDDDTASVTSLN
S1173 HRDDDTASVTSLNSS
T1175 DDDTASVTSLNSSAT
S1176 DDTASVTSLNSSATG
S1179 ASVTSLNSSATGRCL
K1265 NQEKEKLKGPPEKKP
T1327 QEEELEKTVIHNDNE
K1368 SLVLKFPKQQLPPKK
K1374 PKQQLPPKKKRRVGT
K1375 KQQLPPKKKRRVGTT
T1381 KKKRRVGTTVHCDYL
Y1387 GTTVHCDYLNRPHKS
T1400 KSIHRRRTDPMVTLS
T1405 RRTDPMVTLSSILES
S1412 TLSSILESIINDMRD
S1477 LELIVKNSATYNGPK
Y1562 KKFVPDYYKVIVNPM
K1576 MDLETIRKNISKHKY
K1580 TIRKNISKHKYQSRE
K1582 RKNISKHKYQSRESF
T1664 PMTPGPYTPQPPDLY
S1690 ASVFQDESNMSVLDI
S1693 FQDESNMSVLDIPSA
S1699 MSVLDIPSATPEKQV
T1701 VLDIPSATPEKQVTQ
- gap
S1799 MDMENEESMMSYEGD
S1802 ENEESMMSYEGDGGE
Y1803 NEESMMSYEGDGGEA
S1817 ASHGLEDSNISYGSY
S1820 GLEDSNISYGSYEEP
Y1821 LEDSNISYGSYEEPD
S1823 DSNISYGSYEEPDPK
Y1824 SNISYGSYEEPDPKS
S1847 SIGGYEVSEEEEDEE
  TAF1 iso3  
K170 PGPMKKDKDQDSITG
T198 EMGPQEATQAESEDG
S202 QEATQAESEDGKLTL
S307 PPPEQCLSDDEITMM
Y343 PRVAEWRYGPARLWY
Y350 YGPARLWYDMLGVPE
Y364 EDGSGFDYGFKLRKT
T442 GWLPSSMTRNAMAYN
S522 DEKEEATSNSPSKES
S524 KEEATSNSPSKESKK
S526 EATSNSPSKESKKES
K701 VGMATKIKNYYKRKP
K705 TKIKNYYKRKPGKDP
K705 TKIKNYYKRKPGKDP
Y888 SPEQCCAYYSMIAAE
Y889 PEQCCAYYSMIAAEQ
S1138 RMLLAAGSAASGNNH
T1150 NNHRDDDTASVTSLN
S1152 HRDDDTASVTSLNSS
T1154 DDDTASVTSLNSSAT
S1155 DDTASVTSLNSSATG
S1158 ASVTSLNSSATGRCL
K1244 NQEKEKLKGPPEKKP
T1306 QEEELEKTVIHNDNE
K1347 SLVLKFPKQQLPPKK
K1353 PKQQLPPKKKRRVGT
K1354 KQQLPPKKKRRVGTT
T1360 KKKRRVGTTVHCDYL
Y1366 GTTVHCDYLNRPHKS
T1379 KSIHRRRTDPMVTLS
T1384 RRTDPMVTLSSILES
S1391 TLSSILESIINDMRD
S1456 LELIVKNSATYNGPK
Y1541 KKFVPDYYKVIVNPM
K1555 MDLETIRKNISKHKY
K1559 TIRKNISKHKYQSRE
K1561 RKNISKHKYQSRESF
T1643 PMTPGPYTPQPPDLY
S1669 ASVFQDESNMSVLDI
S1672 FQDESNMSVLDIPSA
S1678 MSVLDIPSATPEKQM
T1680 VLDIPSATPEKQMRQ
S1697-p GRLGEEDsDVDIEGY
S1809 MDMENEESMMSYEGD
S1812 ENEESMMSYEGDGGE
Y1813 NEESMMSYEGDGGEA
S1827 ASHGLEDSNIRYQ__
R1830 GLEDSNIRYQ_____
Y1831 LEDSNIRYQ______
- gap
- gap
- gap
  mouse

 
K170 PGPLKKEKDQDDITG
A219 EMGPQDAAQSESKDG
S223 QDAAQSESKDGQLTL
S328-p PLPDQCLsDDEITMM
Y364 PRVAEWRYGPARLWY
Y371 YGPARLWYDMLGVPE
Y385 EDGSGFDYGFKMKKT
T463 GWLPSSMTRNAMAYN
S543-p DEKEEATsNSPsKEN
S545 KEEATsNSPsKENKK
S547-p EATsNSPsKENKKES
K722 VGMATKIKNYYkRKP
K726-ac TKIKNYYkRKPGKDP
K726 TKIKNYYKRKPGKDP
Y909 SPEQCCAYYSMIAAE
Y910 PEQCCAYYSMIAAEQ
S1159-p RMLLAAGsAAAGNNH
T1171-p NNHRDDDtAsVtsLN
S1173-p HRDDDtAsVtsLNSS
T1175-p DDDtAsVtsLNSSAT
S1176-p DDtAsVtsLNSSATG
S1179 AsVtsLNSSATGRCL
K1265 NQEKEKLKGPPEKKP
T1327 QEEELEKTVIHNDNE
K1368 SLVLKFPKQQLPPkK
K1374-ac PKQQLPPkKKRRVGT
K1375 KQQLPPkKKRRVGTT
T1381 kKKRRVGTTVHCDYL
Y1387 GTTVHCDYLNRPHKS
T1400 KSIHRRRTDPMVTLS
T1405 RRTDPMVTLSSILES
S1412 TLSSILESIINDMRD
S1477-p LELIVKNsATYNGPK
Y1562 KKFVPDYYKVIVSPM
K1576 MDLETIRKNISKHKY
K1580 TIRKNISKHKYQSRE
K1582 RKNISKHKYQSRESF
T1664 PMTPGPYTPQPPDLY
S1690-p ASVYQDEsNLsVLDI
S1693-p YQDEsNLsVLDIPSA
S1699 LsVLDIPSATSEKQL
T1701 VLDIPSATSEKQLTQ
- gap
S1799-p MGMENEEsMMsyEGD
S1802-p ENEEsMMsyEGDGGD
Y1803-p NEEsMMsyEGDGGDA
S1817-p ASRGLEDsNIsyGsy
S1820-p GLEDsNIsyGsyEEP
Y1821-p LEDsNIsyGsyEEPD
S1823-p DsNIsyGsyEEPDPK
Y1824-p sNIsyGsyEEPDPKS
S1847-p SIGGYEVsEEEEDEE
  rat

 
R170 PGPVKKERDQDGITG
T219 EMGPQEATQSESKDG
S223 QEATQSESKDGKLTL
S328 PLPEQCLSDDEITMM
Y364 PRVAEWRYGPARLWY
Y371 YGPARLWYDMLGVPE
Y385 EDGSGFDYGFKMKKT
T463 GWLPSSMTRNAMAYN
S543 DEKEEATSNSPSKEN
S545 KEEATSNSPSKENKK
S547 EATSNSPSKENKKES
K722 VGMATKIKNYYKRKP
K726 TKIKNYYKRKPGKDP
K726 TKIKNYYKRKPGKDP
Y909 SPEQCCAYYSMIAAE
Y910 PEQCCAYYSMIAAEQ
S1159 RMLLAAGSAAGGNNH
T1171 NNHRDDDTAsVTsLN
S1173-p HRDDDTAsVTsLNSS
T1175 DDDTAsVTsLNSSAT
S1176-p DDTAsVTsLNSSATG
S1179 AsVTsLNSSATGRCL
K1265 NQEKEKLKGPPEKKP
T1327 QEEELEKTVIHNDNE
K1368 SLVLKFPKQQLPPKK
K1374 PKQQLPPKKKRRVGT
K1375 KQQLPPKKKRRVGTT
T1381 KKKRRVGTTVHCDYL
Y1387 GTTVHCDYLNRPHKS
T1400 KSIHRRRTDPMVTLS
T1405 RRTDPMVTLSSILES
S1412 TLSSILESIINDMRD
S1477 LELIVKNSATYNGPK
Y1562 KKFVPDYYKVIVNPM
K1576-ub MDLETIRkNISkHkY
K1580-ub TIRkNISkHkYQSRE
K1582-ub RkNISkHkYQSRESF
T1664 PMTPGPYTPQAKPPD
S1692 ASVYQDESNLSVLDI
S1695 YQDESNLSVLDIPSA
S1701 LSVLDIPSATSEKQL
T1703 VLDIPSATSEKQLTQ
- gap
S1801 MGMENEESMMSYEGD
S1804 ENEESMMSYEGDGGE
Y1805 NEESMMSYEGDGGEA
S1819-p ASRGLEDsNIsYGsY
S1822-p GLEDsNIsYGsYEEP
Y1823 LEDsNIsYGsYEEPD
S1825-p DsNIsYGsYEEPDPK
Y1826 sNIsYGsYEEPDPKS
S1849 SIGGYEVSEEEEDEE
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