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Protein Page:
PREB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PREB Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. Guanine nucleotide exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Membrane protein, integral
Cellular Component: Golgi membrane; endoplasmic reticulum membrane; integral to membrane; nucleus
Molecular Function: DNA binding
Biological Process: COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; protein transport; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; regulation of transcription, DNA-dependent; transcription, DNA-dependent; unfolded protein response; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification
Reference #:  Q9HCU5 (UniProtKB)
Alt. Names/Synonyms: Mammalian guanine nucleotide exchange factor mSec12; MGC3467; PREB; prolactin regulatory binding-element protein; prolactin regulatory element binding; Prolactin regulatory element-binding protein; SEC12
Gene Symbols: PREB
Molecular weight: 45,468 Da
Basal Isoelectric point: 8.02  Predict pI for various phosphorylation states
Select Structure to View Below

PREB

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K38-ub AGGGGAAkTGIKNGV
0 1 K104-ub AHQQQGNkAEkAGSK
0 1 K107-ub QQGNkAEkAGSKEQG
0 1 K127-ac GAAPAEKkCGAETQH
0 1 K127-ub GAAPAEKkCGAETQH
0 1 E142 EGLELRVENLQAVQT
0 2 Y177-p ATGGTDGyVRVWKVP
0 3 K188-ub WKVPSLEkVLEFKAH
0 11 K209-ub LALGPDGkLVTVGRD
0 4 K218-ub VTVGRDLkASVWQkD
0 1 K224-ub LkASVWQkDQLVTQL
0 3 K272-ub FTVQIPHkRLRQPPP
0 1 T295-p SNFLPLRtKSCGHEV
0 1 T347-p EAHGIVVtDVAFLPE
  mouse

 
K38 AGGGGAAKTGIKNGV
K104 VHQQKGSKAEKSGSK
K107 QKGSKAEKSGSKEQG
K127 GAPPAEKKSGAQVHP
K127 GAPPAEKKSGAQVHP
K142-ub EGVELKVkNLEAVQT
H177 ATGGTDGHVRVWKVP
K188-ub WKVPSLEkVLEFKAH
K209 LTLGPDGKLVTVGWD
K218 VTVGWDFKASVWQKD
K224 FKASVWQKDQLVTQL
K272-ub FTVQIPHkRLRQPPP
T295 STFLPLRTRSCGHEV
T347 EAHGIVVTDVTFLPE
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