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IGF2
The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development. Epigenetic changes of DNA hypomethylation in IGF2 are a cause of Silver-Russell syndrome (SRS). A clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. The phenotypic expression changes during childhood and adolescence, with the facial features and asymmetry usually becoming more subtle with age. Belongs to the insulin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Secreted; Secreted, signal peptide |
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Cellular Component: extracellular space; extracellular region
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Molecular Function: insulin-like growth factor receptor binding; protein serine/threonine kinase activator activity; protein binding; growth factor activity; hormone activity; insulin receptor binding; receptor activator activity
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Biological Process: positive regulation of catalytic activity; ossification; genetic imprinting; positive regulation of mitosis; multicellular organismal development; positive regulation of glycogen biosynthetic process; glucose metabolic process; positive regulation of activated T cell proliferation; positive regulation of protein kinase B signaling cascade; positive regulation of peptidyl-tyrosine phosphorylation; regulation of transcription, DNA-dependent; positive regulation of MAPKKK cascade; positive regulation of cell division; positive regulation of cell proliferation; insulin receptor signaling pathway; positive regulation of protein amino acid phosphorylation; positive regulation of insulin receptor signaling pathway; skeletal development
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Reference #:
P01344 (UniProtKB)
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| Alt. Names/Synonyms: C11orf43; FLJ22066; FLJ44734; IGF-II; IGF2; INSIGF; insulin-like growth factor 2; insulin-like growth factor 2 (somatomedin A); Insulin-like growth factor II; Insulin-like growth factor II Ala-25 Del; insulin-like growth factor type 2; pp9974; Preptin; putative insulin-like growth factor II associated protein; somatomedin A; Somatomedin-A |
| Gene Symbols: IGF2 |
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Molecular weight: 20,140 Da
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Basal Isoelectric point: 9.5
Predict pI for various phosphorylation states
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