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Protein Page:
Daxx (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Daxx a transcriptional co-regulatory protein. Proposed to mediate activation of the JNK pathway and apoptosis via ASK1 in response to signaling from FAS and TGF-betaR2. Glucose deprivation activates the ASK1-SEK1-JNK1-HIPK1 pathway, relocalizing Daxx from the nucleus to the cytoplasm, where Daxx binds to ASK1, and subsequently leads to ASK1 oligomerization. Interaction with HSP27 may prevent interaction with TGF-betaR2 and ASK1 and block DAXX-mediated apoptosis. Seems to act as a transcriptional co- repressor and inhibits PAX3 and ETS1 through direct protein- protein interaction. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Nucleolus
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: heterochromatin; PML body; cytoplasm; nucleolus; cytosol; nucleus; chromosome, pericentric region
Molecular Function: protein homodimerization activity; histone binding; p53 binding; protein N-terminus binding; transcription factor binding; protein kinase binding; protein binding; enzyme binding; androgen receptor binding; ubiquitin protein ligase binding; heat shock protein binding; receptor signaling protein activity; protein kinase activator activity; transcription corepressor activity
Biological Process: chromatin remodeling; nucleosome assembly; transcription, DNA-dependent; induction of apoptosis via death domain receptors; viral reproduction; regulation of transcription, DNA-dependent; cytokinesis after mitosis; regulation of protein ubiquitination; apoptosis; positive regulation of protein kinase activity; androgen receptor signaling pathway; positive regulation of protein amino acid phosphorylation; negative regulation of transcription, DNA-dependent; activation of JNK activity
Reference #:  Q9UER7 (UniProtKB)
Alt. Names/Synonyms: BING2; CENP-C binding protein; DAP6; DAXX; Death domain-associated protein 6; death-associated protein 6; death-domain associated protein; EAP1; ETS1-associated protein 1; Fas death domain-associated protein; Fas-binding protein; hDaxx; MGC126245; MGC126246
Gene Symbols: DAXX
Molecular weight: 81,373 Da
Basal Isoelectric point: 4.8  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Daxx

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: S737‑p, S739‑p
apoptosis, induced: S176‑p, S184‑p
apoptosis, inhibited: S178‑p
transcription, altered: S737‑p, S739‑p
intracellular localization: S668‑p
molecular association, regulation: S178‑p, S668‑p, S737‑p, S739‑p
protein degradation: S178‑p
protein stabilization: S176‑p, S184‑p
sumoylation: S737‑p, S739‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S25-p AAAQPGPsHPLPNAA
0 1 S33-p HPLPNAAsPGAEAPS
0 1 S52-p HGARGSSsSGGKKCY
0 1 S97 NRQQRAHSLFLASAE
1 0 K122-ub RARSRPAkLyVyINE
0 5 Y124-p RSRPAkLyVyINELC
0 5 Y126-p RPAkLyVyINELCTV
2 0 S176-p TNAENTAsQsPRTRG
1 9 S178-p AENTAsQsPRTRGsR
2 0 S184-p QsPRTRGsRRQIQRL
0 1 K208-ub EIRRLQEkELDLsEL
0 9 S213-p QEkELDLsELDDPDS
0 1 K243 FGRLCELKDCsSLtG
0 1 S246-p LCELKDCsSLtGRVI
0 1 T249-p LKDCsSLtGRVIEQR
0 1 K277-ub RIERLINkPGPDTFP
0 1 Y334-p RRHLDLIyNFGCHLT
0 2 Y344-p GCHLTDDyRPGVDPA
0 2 K378-ub RLDEVISkyAMLQDk
0 1 Y379-p LDEVISkyAMLQDkS
0 1 K385-ub kyAMLQDkSEEGERK
0 1 S402-p RARLQGTsSHsADtP
0 1 S405-p LQGTsSHsADtPEAs
0 6 T408-p TsSHsADtPEAsLDs
0 5 S412-p sADtPEAsLDsGEGP
0 4 S415-p tPEAsLDsGEGPsGM
0 1 S420-p LDsGEGPsGMAsQGC
0 20 S424-p EGPsGMAsQGCPsAS
0 1 S429-p MAsQGCPsASRAETD
0 1 T459 EEEEEEATDSEEEED
1 64 S495-p AGKDGDKsPMsSLQI
0 3 S498-p DGDKsPMsSLQIsNE
0 1 S503-p PMsSLQIsNEKNLEP
1 8 L508 QIsNEKNLEPGkQIs
0 1 K512-ac EKNLEPGkQIsRSSG
0 1 K512-ub EKNLEPGkQIsRSSG
0 2 S515-p LEPGkQIsRSSGEQQ
0 11 S517 PGkQIsRSSGEQQNK
0 1 S529 QNKGRIVSPSLLSEE
0 1 S531 KGRIVSPSLLSEEPL
1 0 S564-p LEEESPVsQLFELEI
0 2 G626 PHNWGDSGPPCkkSR
4 0 K630-sm GDSGPPCkkSRKEKK
4 0 K631-sm DSGPPCkkSRKEKKQ
0 2 T639-p SRKEKKQtGsGPLGN
0 2 S641-p KEKKQtGsGPLGNsy
0 2 S647-p GsGPLGNsyVERQRs
0 1 Y648-p sGPLGNsyVERQRsV
0 11 S654-p syVERQRsVHEKNGK
0 1 C664 EKNGKKICtLPsPPs
0 2 T665-p KNGKKICtLPsPPsP
4 7 S668-p KKICtLPsPPsPLAs
1 2 P670 ICtLPsPPsPLAsLA
0 16 S671-p CtLPsPPsPLAsLAP
0 4 S675-p sPPsPLAsLAPVADS
0 15 S688-p DSSTRVDsPsHGLVt
0 6 S690-p STRVDsPsHGLVtSS
0 2 T695-p sPsHGLVtSSLCIPs
0 16 S702-p tSSLCIPsPARLsQt
0 1 S707-p IPsPARLsQtPHsQP
0 3 T709-p sPARLsQtPHsQPPR
0 1 S712-p RLsQtPHsQPPRPGT
1 12 S737-p PEEIIVLsDsD____
1 13 S739-p EIIVLsDsD______
  mouse

 
S25 AAAQPGPSNLPPNPA
S33 NLPPNPASTGPGPGL
S58 under review
S103 KLQQRAQSVFLASAE
K128 RSRKRPAKIYVYINE
Y130 RKRPAKIYVYINELC
Y132 RPAKIYVYINELCTV
S182 TNTENTASEASRTRG
A184 TENTASEASRTRGSR
S190 EASRTRGSRRQIQRL
K214 EIRRLQEKELDLsEL
S219-p QEKELDLsELDDPDS
K249-ub FGRLCELkDCSSLTG
S252 LCELkDCSSLTGRVI
T255 LkDCSSLTGRVIEQR
K283 RIERLINKPGLDTFP
Y340 RRHLDLIYNFGCHLT
Y350 GCHLTDDYRPGVDPA
K384 RLDEVISKYAMMQDK
Y385 LDEVISKYAMMQDKT
K391 KYAMMQDKTEEGERQ
- gap
- gap
- gap
S418 PSDPPQASSESGEGP
S421 PPQASSESGEGPSGM
S426 SESGEGPSGMASQEC
S430 EGPSGMASQECPTTS
T435 MASQECPTTSKAETD
T472-p EEEEKEAtEDEDEDL
S502-p GDNEGNEsPTSPSDF
S505 EGNEsPTSPSDFFHR
F510 PTSPSDFFHRRNsEP
S515-p DFFHRRNsEPAEGLR
E519 RRNsEPAEGLRtPEG
E519 RRNsEPAEGLRtPEG
L521 NsEPAEGLRtPEGQQ
T523-p EPAEGLRtPEGQQKR
T535-p QKRGLTEtPAsPPGA
S538-p GLTEtPAsPPGASLD
S570 LGDESPVSQLAELEM
S626-p SHTWRDAsPPSKRFR
K630 RDAsPPSKRFRKEKK
R631 DAsPPSKRFRKEKKQ
L639 FRKEKKQLGSGLLGN
S641 KEKKQLGSGLLGNSY
S647 GSGLLGNSYIKEPMA
Y648 SGLLGNSYIKEPMAQ
M653 NSYIKEPMAQQDSGQ
S663-p QDSGQNTsVQPMPsP
V664 DSGQNTsVQPMPsPP
M667 QNTsVQPMPsPPLAs
S669-p TsVQPMPsPPLAsVA
P670 sVQPMPsPPLAsVAS
S674-p MPsPPLAsVASVADS
S687-p DSSTRVDsPsHELVt
S689-p STRVDsPsHELVtSS
T694-p sPsHELVtSSLCSPs
S701-p tSSLCSPsPSLLLQT
L706 SPsPSLLLQTPQAQS
T708 sPSLLLQTPQAQSLR
A711 LLLQTPQAQSLRQCI
S736-p PEEIIVLsDsD____
S738-p EIIVLsDsD______
  rat

 
S25 AAAQPGPSNPASNPV
S33 NPASNPVSPGPEASG
N52 HGDGGSSNSGSRKCY
S97-p KLQQRAQsAFLASAE
K122 RSRNRPAKLYVYINE
Y124 RNRPAKLYVYINELC
Y126 RPAKLYVYINELCTV
S174 TNTETTASEASRTRG
A176 TETTASEASRTRGSR
S182 EASRTRGSRRQIQRL
K206 EIQRLQEKELDLSEL
S211 QEKELDLSELDDPDS
K241 FGRLCDLKDCSSLTG
S244 LCDLKDCSSLTGKVI
T247 LKDCSSLTGKVIEQR
K275 RIERLINKPGPDTFP
Y332 RRHLDLIYNFGCHLT
Y342 GCHLTDDYRPGVDPA
K376 RLDEVISKYAMMQDK
Y377 LDEVISKYAMMQDKS
K383 KYAMMQDKSEEGERQ
S400 RARLLATSQSSDLPK
S402 RLLATSQSSDLPKAS
L405 ATSQSSDLPKASSDS
S409 SSDLPKASSDSGEGP
S412 LPKASSDSGEGPSGV
S417 SDSGEGPSGVASQED
S421 EGPSGVASQEDPTTP
T426 VASQEDPTTPKAETE
T456 EEEEEEATEDEDEDL
S485-p GDNEDDKsPAsPSPI
S488-p EDDKsPAsPSPIFRR
- under review  
S499 IFRRKEFSNPQKGSG
K503 KEFSNPQKGSGPQEE
K503 KEFSNPQKGSGPQEE
S505 FSNPQKGSGPQEEQQ
P507 NPQKGSGPQEEQQER
T519 QERGLTGTPAsPLEA
S522-p GLTGTPAsPLEASPG
S554 LAGESPVSQLSELDM
S617 SHPCRDASPPSKRFR
K621 RDASPPSKRFRKEKK
R622 DASPPSKRFRKEKKQ
L630 FRKEKKQLGPGPLGN
P632 KEKKQLGPGPLGNSY
S638 GPGPLGNSYVKKQTM
Y639 PGPLGNSYVKKQTMA
M645 SYVKKQTMAQQDSGW
S655 QDSGWKISVLSTPSS
V656 DSGWKISVLSTPSSP
T659 WKISVLSTPSSPLAS
S661 ISVLSTPSSPLASVG
S662 SVLSTPSSPLASVGP
S666 TPSSPLASVGPVADS
S679 DSSTRVDSPSHELVT
S681 STRVDSPSHELVTSS
T686 SPSHELVTSSLCNPS
S693 TSSLCNPSPSLILQT
L698 NPSPSLILQTPQSQS
T700 SPSLILQTPQSQSPR
S703 LILQTPQSQSPRPCI
S728 PEEIIVLSDSD____
S730 EIIVLSDSD______
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