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Protein Page:
NBR1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NBR1 Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. Homooligomer and heterooligomer. Interacts with TRIM55. Interacts with SQSTM1, titin/TTN, RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Binds to ubiquitin and ubiquitinated proteins. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 17q21.31
Cellular Component: membrane; lysosome; late endosome; M band; autophagic vacuole; cytoplasmic vesicle; cytosol
Molecular Function: protein binding; ubiquitin binding; zinc ion binding; mitogen-activated protein kinase binding
Biological Process: regulation of stress-activated MAPK cascade; macroautophagy; negative regulation of osteoblast differentiation; regulation of bone mineralization; protein oligomerization
Reference #:  Q14596 (UniProtKB)
Alt. Names/Synonyms: 1A1-3B; 1A13B; Cell migration-inducing gene 19 protein; FLJ55359; FLJ98272; KIAA0049; M17S2; Membrane component chromosome 17 surface marker 2; MIG19; migration-inducing protein 19; NBR1; neighbor of BRCA1 gene 1; Neighbor of BRCA1 gene 1 protein; Next to BRCA1 gene 1 protein; Protein 1A1-3B
Gene Symbols: NBR1
Molecular weight: 107,413 Da
Basal Isoelectric point: 5.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NBR1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K100-ub PPPVVGAkRLAARAG
0 1 K108-ub RLAARAGkkPLAHYs
0 3 K109-ub LAARAGkkPLAHYss
0 4 S115-p kkPLAHYssLVRVLG
0 5 S116-p kPLAHYssLVRVLGS
0 4 K172-ub VVNETVEkLEQkLHE
0 3 K176-ub TVEkLEQkLHEKLVL
0 1 K180 LEQkLHEKLVLQNPS
0 1 K274 SEPFCHSKYstPRLP
0 1 S276-p PFCHSKYstPRLPAA
0 4 T277-p FCHSKYstPRLPAAL
0 2 K313-ac RAEKKQRkAEVkELk
0 1 K317-ub KQRkAEVkELkKQLK
0 1 K320-ub kAEVkELkKQLKLHR
0 1 K328 KQLKLHRKIHLWNSI
0 1 S334 RKIHLWNSIHGLQSP
0 1 S340 NSIHGLQSPKSPLGR
0 1 K405 MKNTGNVKWSADTKL
0 1 K426 LTLASTEKKDVLVPC
0 7 K464-ub SHWRLSHkGQQFGPR
0 1 S486-p DPFPSEEsPDNIEKG
0 2 K499-ub KGMISSSkTDDLTCQ
0 6 K515-ub EETFLLAkEERQLGE
0 2 K537 TAACIPQKAkNVASE
0 15 K537-ub TAACIPQkAkNVASE
0 5 K539-ub ACIPQkAkNVASERE
0 1 T581-p LERVPHNtPVDVtPC
1 1 T586-p HNtPVDVtPCMsPLP
0 3 S590-p VDVtPCMsPLPHDsP
0 2 S596-p MsPLPHDsPLIEKPG
0 2 S622-p GFKALPDsMVsVKRK
0 2 S625-p ALPDsMVsVKRKAEN
0 4 S656-p VCETVIRsLtLDAAP
0 3 T658-p ETVIRsLtLDAAPDH
0 2 S673-p NPPCRQKsLQMTFAL
0 1 T677 RQKsLQMTFALPEGP
0 3 K767-ub LERGAEGkPGVEAGQ
0 1 S824-p LPPSLPRssPCVHHH
0 1 S825-p PPSLPRssPCVHHHG
0 1 S833-p PCVHHHGsPGVDLPV
0 2 - gap
0 2 K887-ub SIAGGLVkGALSVAA
0 4 K898-ub SVAASAYkALFAGPP
  mouse

 
N101 LPKNVVENQAAARTG
K109 QAAARTGKkPLAHYS
K110-ub AAARTGKkPLAHYSS
S116 KkPLAHYSSLVRVLG
S117 kPLAHYSSLVRVLGS
K173-ub VVKETVEkLEQRLQE
R177 TVEkLEQRLQEkLVL
K181-ub LEQRLQEkLVLQKPL
K275-ub SEPFFYSkYSAPRLP
S277 PFFYSkYSAPRLPAA
A278 FFYSkYSAPRLPAAL
K314 RAEKKQRKAEVKELK
K318 KQRKAEVKELKKQLK
K321 KAEVKELKKQLKLHR
K329-ub KQLKLHRkIHLWNsI
S335-p RkIHLWNsIHGLQsP
S341-p NsIHGLQsPKSPLGR
K406-ub MKNTGNVkWNTDTKL
K427-ub LTLASTEkKDVLVPC
K465-ub SHWRLSHkGQQFGPR
S487 DPFPSSESPDNVEGD
K500 GDRISSSKADDFSCE
E516 EEAFLLAEEEIPLGE
K538-ac TGASASQkTRRAASE
K538-ub TGASASQkTRRAASE
R540 ASASQkTRRAASERE
T582 LERVPHNTPVDMTPC
T587 HNTPVDMTPCMSPLP
S591 VDMTPCMSPLPHDSP
S597 MSPLPHDSPLIEKPG
S623 GFKAPPDSTVSAKRK
S626 APPDSTVSAKRKAET
S657-p VCETVIRsLtLDAAP
T659-p ETVIRsLtLDAAPDH
S674 NPPCRQRSPQRELQL
K703-ub CRKDSSLkFALPEEG
- gap
S842 LPAALSRSAPCGQCE
- gap
S851 PCGQCESSGVDSPGV
S860 VDSPGVDSPATMHEV
K909-ub SIAGGLVkGALSVAA
K920-ub SVAASAYkALFSGPP
  rat

 
K101 LPQTVVEKQATARTG
K109 QATARTGKKPLAHYS
K110 ATARTGKKPLAHYSS
S116 KKPLAHYSSLVRVLG
S117 KPLAHYSSLVRVLGS
K173 VVKETVEKLEQRLQE
R177 TVEKLEQRLQEKLVL
K181 LEQRLQEKLVLQKPP
K276 SEPFFYSKYPTPRLP
P278 PFFYSKYPTPRLPAA
T279 FFYSKYPTPRLPAAL
K315 RAEKKQRKAEVKELK
K319 KQRKAEVKELKKQLK
K322 KAEVKELKKQLKLHR
K330 KQLKLHRKIHLWNSI
S336 RKIHLWNSIHGLQSP
S342 NSIHGLQSPKSPLGR
K407 MKNTGNVKWSADTKL
K428 LTLASTEKKDVLVPC
K466-ub LHWRLSHkGQQFGPR
S488 DPFPSSESPVNLERD
K501 RDGISSSKADDFTCE
E517 EEAFLLAEEEIPLGE
K539 TGSSAPQKTQHAASE
K539 TGSSAPQKTQHAASE
Q541 SSAPQKTQHAASERE
T583 LERVPHNTPVDVTPR
T588 HNTPVDVTPRMsPLP
S592-p VDVTPRMsPLPHDsP
S598-p MsPLPHDsPLIEKPG
S624 GLKASPDSTVLTKRK
- gap
S658 VCETVIRSLTLDAAP
T660 ETVIRSLTLDAAPDH
S675 NPPCRQRSPQRELQL
K704 CRKDSSLKFALPEEG
- gap
S842 LPAALSRSAPCGQYE
- gap
- gap
S855-p YEAPRVDsPVTIQEV
K904 SIAGGLVKGALSVAA
K915 SVAASAYKALFSGPP
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