a myeloid cell leukemia protein of the Bcl-2 family of proteins. Two alternatively spliced transcripts encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing. Note: This description may include information from UniProtKB.
Protein type: Channel, misc.; Membrane protein, integral; Mitochondrial; Apoptosis; Inhibitor protein
Cellular Component: nucleoplasm; mitochondrial outer membrane; mitochondrion; membrane; mitochondrial matrix; cytoplasm; integral to membrane
Molecular Function: protein binding; protein heterodimerization activity; protein channel activity; BH3 domain binding
Biological Process: apoptosis; response to cytokine stimulus; multicellular organismal development; cell fate determination; cellular homeostasis; negative regulation of apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.