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Protein Page:
MCL1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MCL1 a myeloid cell leukemia protein of the Bcl-2 family of proteins. Two alternatively spliced transcripts encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Inhibitor protein; Channel, misc.; Mitochondrial; Apoptosis
Cellular Component: nucleoplasm; mitochondrial outer membrane; mitochondrion; membrane; mitochondrial matrix; cytoplasm; integral to membrane; cytosol; nucleus
Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; protein channel activity; BH3 domain binding
Biological Process: apoptotic mitochondrial changes; DNA damage response, signal transduction resulting in induction of apoptosis; multicellular organismal development; response to cytokine stimulus; cellular homeostasis; cell fate determination
Reference #:  Q07820 (UniProtKB)
Alt. Names/Synonyms: Bcl-2-like protein 3; Bcl-2-related protein EAT/mcl1; Bcl2-L-3; BCL2L3; EAT; Induced myeloid leukemia cell differentiation protein Mcl-1; Mcl-1; MCL1; mcl1/EAT; MCL1L; MCL1S; MGC104264; MGC1839; myeloid cell leukemia ES; myeloid cell leukemia sequence 1 (BCL2-related); myeloid cell leukemia sequence 1, isoform 1; TM
Gene Symbols: MCL1
Molecular weight: 37,337 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MCL1

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: T92‑p, S159‑p
apoptosis, induced: S121‑p, T163‑p
apoptosis, inhibited: S64‑p
cell growth, altered: T92‑p, T163‑p
molecular association, regulation: S64‑p, T92‑p, T163‑p
protein degradation: T92‑p, S159‑p
protein stabilization: T92‑p, T163‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 43 K40-ub GRLLATEkEASARRE
4 3 S64-p IGGSAGAsPPSTLTP
3 3 T92-p EVPDVTAtPARLLFF
4 1 S121-p PAADAIMsPEEELDG
0 10 K136-ub YEPEPLGkRPAVLPL
0 1 S150-p LLELVGEsGNNtSTD
0 8 N152 ELVGEsGNNtSTDGs
0 3 T154-p VGEsGNNtSTDGsLP
3 3 S159-p NNtSTDGsLPStPPP
7 19 T163-p TDGsLPStPPPAEEE
0 33 K194-ub REQATGAkDTkPMGR
0 27 K197-ub ATGAkDTkPMGRSGA
0 4 - gap
0 3 K234-ub AFQGMLRkLDIkNED
0 7 K238-ub MLRkLDIkNEDDVkS
0 13 K244-ub IkNEDDVkSLSRVMI
0 1 K276-ub SFGAFVAkHLkTINQ
0 4 K279-ub AFVAkHLkTINQESC
0 7 K308-ub TKRDWLVkQRGWDGF
0 1 Y347-p GVGAGLAyLIR____
13297 : Phospho-Mcl-1 (Ser64) Antibody
4579 : Phospho-Mcl-1 (Ser159/Thr163) Antibody
4579 : Phospho-Mcl-1 (Ser159/Thr163) Antibody
  MCL1 iso2  
K40 GRLLATEKEASARRE
S64 IGGSAGASPPSTLTP
T92 EVPDVTATPARLLFF
S121 PAADAIMSPEEELDG
K136 YEPEPLGKRPAVLPL
S150 LLELVGESGNNTSTD
N152 ELVGESGNNTSTDGS
T154 VGESGNNTSTDGSLP
S159 NNTSTDGSLPSTPPP
T163 TDGSLPSTPPPAEEE
K194 REQATGAKDTKPMGR
K197 ATGAKDTKPMGRSGA
K267-ub SWFGISNkIALL___
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

 
K39-ub RLVAEEAkARREGGG
- gap
S73 EDPDVTASAERRLHK
S102-p SAAAAIVsPEEELDG
K117 CEPEAIGKRPAVLPL
A131 LLERVSEAAkSsGAD
K133-ub ERVSEAAkSsGADGs
S135-p VSEAAkSsGADGsLP
S140-p kSsGADGsLPStPPP
T144-p ADGsLPStPPPPEEE
K175-ub REQATGSkDSkPLGE
K178-ub ATGSkDSkPLGEAGA
- gap
K215 AFQGMLRKLDIkNEG
K219-ub MLRKLDIkNEGDVKS
K225 IkNEGDVKSFSRVMV
K257 SFGAFVAKHLkSVNQ
K260-ub AFVAKHLkSVNQESF
K289 TKRDWLVKQRGWDGF
Y328 GVGAGLAYLIR____
4579 : Phospho-Mcl-1 (Ser159/Thr163) Antibody
4579 : Phospho-Mcl-1 (Ser159/Thr163) Antibody
  rat

 
K39 RLAAEEAKARREGGG
- gap
S73 EDPDVTASAERRLLK
S101 ASAAAIMSPEEELDG
K116 CEPEVLSKRPAVLPL
A130 LLERVSEAAKSSGAD
K132 ERVSEAAKSSGADGS
S134 VSEAAKSSGADGSLP
S139 KSSGADGSLPStPPP
T143-p ADGSLPStPPPPEEE
K174 REQATGSKDAKPLGE
K177 ATGSKDAKPLGEAGA
- gap
K214 AFQGMLRKLDIKNED
K218 MLRKLDIKNEDDVKS
K224 IKNEDDVKSFSRVMT
K256 SFGAFVAKHLKSINQ
K259 AFVAKHLKSINQESC
K288 TKRDWLVKQRGWDGF
Y327 GVGAGLAYLIR____
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