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MCL1 (human)

Overview MCL1 a myeloid cell leukemia protein of the Bcl-2 family of proteins. Two alternatively spliced transcripts encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing. Note: This description may include information from UniProtKB. Protein type: Channel, misc.; Membrane protein, integral; Mitochondrial; Apoptosis; Inhibitor protein Cellular Component: nucleoplasm; mitochondrial outer membrane; mitochondrion; membrane; mitochondrial matrix; cytoplasm; integral to membrane Molecular Function: protein binding; protein heterodimerization activity; protein channel activity; BH3 domain binding Biological Process: apoptosis; response to cytokine stimulus; multicellular organismal development; cell fate determination; cellular homeostasis; negative regulation of apoptosis Reference #:  Q07820 (UniProtKB) Alt. Names/Synonyms: Bcl-2-like protein 3; Bcl-2-related protein EAT/mcl1; Bcl2-L-3; BCL2L3; EAT; Induced myeloid leukemia cell differentiation protein Mcl-1; Mcl-1; MCL1; mcl1/EAT; MCL1L; MCL1S; MGC104264; MGC1839; myeloid cell leukemia ES; myeloid cell leukemia sequence 1 (BCL2-related); myeloid cell leukemia sequence 1, isoform 1; TM Gene Symbols: MCL1 Molecular weight: 37,337 Da Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  Inhibition of Apoptosis  |  Jak/Stat/IL-6 Signaling  |  Mitochondrial Control of Apoptosis Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MCL1 2KBW - A=163-326 (human) 2NLA - A=209-327 (human) 2PQK - A=172-327 (human) 3D7V - A=209-327 (human) 3IO9 - A=209-327 (human) 3KJ0 - A=172-327 (human) 3KJ1 - A=172-327 (human) 3KJ2 - A=172-327 (human) 3KZ0 - A/B=172-327 (human) 3MK8 - A=172-327 B=208-228 (human) 3PK1 - A/C=174-326 (human) 3TWU - B=73-88 (human) 4HW2 - F/A/D/C/E/B=172-323 (human) 4HW3 - F/A/J/K/E/B/H/C/D/I/G/L=172-323 (human) 4HW4 - A/B=172-327 (human) 1WSX - A=152-308 (mouse) 2JM6 - B=148-308 (mouse) 2NLA - A=152-189 (mouse) 2ROC - A=152-308 (mouse) 2ROD - A=152-308 (mouse) 3D7V - A=152-189 (mouse) 3IO9 - A=152-189 (mouse) 4G35 - A=152-308 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2KBW 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1 3TWU 4HW2 4HW3 4HW4  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
apoptosis, altered: T92‑p, S159‑p apoptosis, induced: S121‑p, T163‑p apoptosis, inhibited: S64‑p cell growth, altered: T92‑p, T163‑p molecular association, regulation: S64‑p, T92‑p, T163‑p protein degradation: T92‑p, S159‑p protein stabilization: T92‑p, T163‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	42		K40-u	GRLLATEkEASARRE
0	1		-	gap
4	2		S64-p	IGGSAGAsPPSTLTP
3	3		T92-p	EVPDVTAtPARLLFF
4	1		S121-p	PAADAIMsPEEELDG
0	10		K136-u	YEPEPLGkRPAVLPL
0	1		S150-p	LLELVGEsGNNtSTD
0	8		N152	ELVGEsGNNtSTDGs
0	2		T154-p	VGEsGNNtSTDGsLP
3	2		S159-p	NNtSTDGsLPStPPP
7	17		T163-p	TDGsLPStPPPAEEE
0	33		K194-u	REQATGAkDTkPMGR
0	27		K197-u	ATGAkDTkPMGRSGA
0	3		K234-u	AFQGMLRkLDIkNED
0	7		K238-u	MLRkLDIkNEDDVkS
0	13		K244-u	IkNEDDVkSLSRVMI
0	1		K276-u	SFGAFVAkHLkTINQ
0	4		K279-u	AFVAkHLkTINQESC
0	7		K308-u	TKRDWLVkQRGWDGF
0	4		-	gap
0	1		Y347-p	GVGAGLAyLIR____

	MCL1 iso2
K40	GRLLATEKEASARRE
-	gap
S64	IGGSAGASPPSTLTP
T92	EVPDVTATPARLLFF
S121	PAADAIMSPEEELDG
K136	YEPEPLGKRPAVLPL
S150	LLELVGESGNNTSTD
N152	ELVGESGNNTSTDGS
T154	VGESGNNTSTDGSLP
S159	NNTSTDGSLPSTPPP
T163	TDGSLPSTPPPAEEE
K194	REQATGAKDTKPMGR
K197	ATGAKDTKPMGRSGA
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
K267-u	SWFGISNkIALL___
-	gap

	mouse
-	gap
K39-u	RLVAEEAkARREGGG
-	gap
S73	EDPDVTASAERRLHK
S102-p	SAAAAIVsPEEELDG
K117	CEPEAIGKRPAVLPL
A131	LLERVSEAAkSSGAD
K133-u	ERVSEAAkSSGADGs
S135	VSEAAkSSGADGsLP
S140-p	kSSGADGsLPStPPP
T144-p	ADGsLPStPPPPEEE
K175-u	REQATGSkDSkPLGE
K178-u	ATGSkDSkPLGEAGA
K215	AFQGMLRKLDIkNEG
K219-u	MLRKLDIkNEGDVKS
K225	IkNEGDVKSFSRVMV
K257	SFGAFVAKHLkSVNQ
K260-u	AFVAKHLkSVNQESF
K289	TKRDWLVKQRGWDGF
-	gap
Y328	GVGAGLAYLIR____

	rat
-	gap
K39	RLAAEEAKARREGGG
-	gap
S73	EDPDVTASAERRLLK
S101	ASAAAIMSPEEELDG
K116	CEPEVLSKRPAVLPL
A130	LLERVSEAAKSSGAD
K132	ERVSEAAKSSGADGS
S134	VSEAAKSSGADGSLP
S139	KSSGADGSLPStPPP
T143-p	ADGSLPStPPPPEEE
K174	REQATGSKDAKPLGE
K177	ATGSKDAKPLGEAGA
K214	AFQGMLRKLDIKNED
K218	MLRKLDIKNEDDVKS
K224	IKNEDDVKSFSRVMT
K256	SFGAFVAKHLKSINQ
K259	AFVAKHLKSINQESC
K288	TKRDWLVKQRGWDGF
-	gap
Y327	GVGAGLAYLIR____

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