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Protein Page:
KPNB1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
KPNB1 a nuclear import protein nuclear protein import that functions either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re- exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports PRKCI into the nucleus. Forms a complex with an importin alpha subunit. Forms a heterodimer with IPO7. Interacts with IPO7, SNUPN, RPL23A and XPO1. Two isoforms of the human protein have been reported. Belongs to the importin beta family. Note: This description may include information from UniProtKB.
Protein type: Nuclear import; Karyopherin
Cellular Component: nucleoplasm; nuclear membrane; cytoplasm; nucleolus; nuclear pore; nuclear envelope; cytosol; nucleus
Molecular Function: protein domain specific binding; protein binding; enzyme binding; zinc ion binding; nuclear localization sequence binding; Ran GTPase binding; protein transporter activity
Biological Process: ribosomal protein import into nucleus; viral reproduction; protein import into nucleus, translocation; apoptosis; protein import into nucleus; cytokine and chemokine mediated signaling pathway; viral infectious cycle; DNA fragmentation during apoptosis; NLS-bearing substrate import into nucleus; cell structure disassembly during apoptosis
Reference #:  Q14974 (UniProtKB)
Alt. Names/Synonyms: IMB1; Impnb; importin 1; importin 90; importin beta-1 subunit; Importin subunit beta-1; Importin-90; IPO1; IPOB; karyopherin (importin) beta 1; Karyopherin subunit beta-1; KPNB1; MGC2155; MGC2156; MGC2157; NTF97; Nuclear factor p97; Pore targeting complex 97 kDa subunit; PTAC97
Gene Symbols: KPNB1
Molecular weight: 97,170 Da
Basal Isoelectric point: 4.68  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

KPNB1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T5-p ___MELItILEKtVs
0 1 T10-p LItILEKtVsPDRLE
0 5 S12-p tILEKtVsPDRLELE
0 3 K23-ub LELEAAQkFLERAAV
0 1 S41-p PTFLVELsRVLANPG
0 1 S50-p VLANPGNsQVARVAA
0 1 K62 VAAGLQIKNSLTSkD
0 6 K62-ub VAAGLQIkNSLTSkD
0 2 K68-ub IkNSLTSkDPDIKAQ
0 1 K68-sc IkNSLTSkDPDIKAQ
1 1 Y76-p DPDIKAQyQQRWLAI
0 1 S170-p PEQLQDKsNEILtAI
0 1 T175-p DKsNEILtAIIQGMR
0 1 K191-ac EEPSNNVkLAATNAL
0 1 K206 LNSLEFTKANFDkES
1 3 K206-ub LNSLEFTkANFDkES
1 1 K211-ub FTkANFDkESERHFI
0 2 K211-ac FTkANFDkESERHFI
0 1 K372-ub PHVLPFIkEHIkNPD
0 4 K376-ub PFIkEHIkNPDWRYR
0 1 K403 GPEPSQLKPLVIQAM
0 1 S526-p GHQNNLRssAyEsLM
0 1 S527-p HQNNLRssAyEsLME
0 2 Y529-p NNLRssAyEsLMEIV
0 1 S531-p LRssAyEsLMEIVkN
0 50 K537-ub EsLMEIVkNsAkDCY
0 1 S539-p LMEIVkNsAkDCYPA
0 25 K541-ub EIVkNsAkDCYPAVQ
0 9 K549-ub DCYPAVQkTTLVIME
0 1 T587-p LQSLLCAtLQNVLRK
0 1 S617-p SLLRMFQsTAGsGGV
0 1 S621-p MFQsTAGsGGVQEDA
0 1 S633 EDALMAVSTLVEVLG
0 1 T634 DALMAVSTLVEVLGG
0 4 K651-ub LKYMEAFkPFLGIGL
0 12 K710-ub ENVHRSVkPQILSVF
0 3 K730-ub AIGGEFKkYLEVVLN
0 1 S743-p LNTLQQAsQAQVDKs
0 4 S750-p sQAQVDKsDyDMVDY
0 23 Y752-p AQVDKsDyDMVDYLN
0 12 K777-ub TGIVQGLkGDQENVH
0 1 K835-ac AFGKDVLkLVEARPM
0 8 K835-ub AFGKDVLkLVEARPM
0 1 S853-p LLTEGRRsKtNKAKT
0 1 T855-p TEGRRsKtNKAKTLA
0 10 K867-ac TLATWATkELRKLKN
0 1 K867-ub TLATWATkELRKLKN
  mouse

 
T5 ___MELITILEKTVS
T10 LITILEKTVSPDRLE
S12 TILEKTVSPDRLELE
K23-ub LELEAAQkFLERAAV
S41 PTFLVELSRVLANPG
S50 VLANPGNSQVARVAA
K62-ac VAAGLQIkNSLTSkD
K62-ub VAAGLQIkNSLTSkD
K68-ub IkNSLTSkDPDIKAQ
K68 IkNSLTSKDPDIKAQ
Y76 DPDIKAQYQQRWLAI
S170 PEQLQDKSNEILTAI
T175 DKSNEILTAIIQGMR
K191 EEPSNNVKLAATNAL
K206-ac LNSLEFTkANFDkES
K206 LNSLEFTKANFDkES
K211 FTkANFDKESERHFI
K211-ac FTkANFDkESERHFI
K372 PHVLPFIKEHIkNPD
K376-ub PFIKEHIkNPDWRYR
K403-ac GPEPNQLkPLVIQAM
S526 GHQNNLRSSAYESLM
S527 HQNNLRSSAYESLME
Y529 NNLRSSAYESLMEIV
S531 LRSSAYESLMEIVkN
K537-ub ESLMEIVkNSAKDCY
S539 LMEIVkNSAKDCYPA
K541 EIVkNSAKDCYPAVQ
K549 DCYPAVQKTTLVIME
T587 LQSLLCATLQNVLRK
S617 SLLRMFQSTAGSGGV
S621 MFQSTAGSGGVQEDA
S633-p EDALMAVstLVEVLG
T634-p DALMAVstLVEVLGG
K651 LKYMEAFKPFLGIGL
K710-ub ENVHRSVkPQILSVF
K730 AIGGEFKKYLEVVLN
S743 LNTLQQASQAQVDKS
S750 SQAQVDKSDFDMVDY
F752 AQVDKSDFDMVDYLN
K777 TGIVQGLKGDQENVH
K835 AFGKDVLKLVEARPM
K835-ub AFGKDVLkLVEARPM
S853 LLTEGRRSKTNKAKT
T855 TEGRRSKTNKAKTLA
K867 TLATWATKELRKLKN
K867 TLATWATKELRKLKN
  rat

 
T5 ___MELITILEKTVS
T10 LITILEKTVSPDRLE
S12 TILEKTVSPDRLELE
K23 LELEAAQKFLERAAV
S41 PTFLVELSRVLANPG
S50 VLANPGNSQVARVAA
R62 VAAGLQIRLLTSKDP
R62 VAAGLQIRLLTSKDP
K67 QIRLLTSKDPDIKAQ
K67 QIRLLTSKDPDIKAQ
Y75 DPDIKAQYQQRWLAI
S169 PEQLQDKSNEILTAI
T174 DKSNEILTAIIQGMR
K190 EEPSNNVKLAATNAL
K205 LNSLEFTKANFDKES
K205 LNSLEFTKANFDKES
K210 FTKANFDKESERHFI
K210 FTKANFDKESERHFI
K371 PHVLPFIKEHIKNPD
K375 PFIKEHIKNPDWRYR
K402 GPEPNQLKPLVIQAM
S525 GHQNNLRSSAYESLM
S526 HQNNLRSSAYESLME
Y528 NNLRSSAYESLMEIV
S530 LRSSAYESLMEIVKN
K536 ESLMEIVKNSAKDCY
S538 LMEIVKNSAKDCYPA
K540 EIVKNSAKDCYPAVQ
K548 DCYPAVQKTTLVIME
T586 LQSLLCATLQNVLWK
S616 SLLRMFQSTAGSGGV
S620 MFQSTAGSGGVQEDA
S632 EDALMAVSTLVEVLG
T633 DALMAVSTLVEVLGG
K650 LKYMEAFKPFLGIGL
K709 ENVHRSVKPQILSVF
K729 AIGGEFKKYLEVVLN
S742 LNTLQQASQAQVDKS
S749 SQAQVDKSDFDMVDY
F751 AQVDKSDFDMVDYLN
K776 TGIVQGLKGDQENVH
K834 AFGKDVLKLVEARPM
K834 AFGKDVLKLVEARPM
S852 LLTEGRRSKTNKAKT
T854 TEGRRSKTNKAKTLA
K866 TLATWATKELRKLKN
K866 TLATWATKELRKLKN
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