NAT6 (human)

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Protein Page:

NAT6 (human)

p	Phosphorylation
a	Acetylation
m	Methylation
m1	Mono-methylation
m2	Di-methylation
m3	Tri-methylation
u	Ubiquitination
s	Sumoylation
n	Neddylation
gl	O-GlcNAc
ga	O-GalNAc
h	Palmitoylation
ad	Adenylylation
sn	S-Nitrosylation
ca	Caspase cleavage

Overview

NAT6 Seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by Asp/Glu/Asn. May act as a tumor suppressor. Belongs to the acetyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.

Protein type: Secondary Metabolites Metabolism - limonene and pinene degradation; Acetyltransferase; Lipid Metabolism - glycerophospholipid; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - phenylalanine; EC 2.3.1.-

Cellular Component: mitochondrion; cytoplasm

Molecular Function: N-acetyltransferase activity

Reference #: Q93015 (UniProtKB)

Alt. Names/Synonyms: FUS-2; FUS2; N-acetyltransferase 6; N-acetyltransferase 6 (GCN5-related); NAT6; Protein fus-2; Protein fusion-2; putative tumor suppressor

Gene Symbols: NAT6

Molecular weight: 31,445 Da

Basal Isoelectric point: 7.75 Predict pI for various phosphorylation states

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	NAT6

Modification Sites and Domains

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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend

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SS SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.		human ► Hide Isoforms

0	1	-	gap
0	1	S8	MELILSTSPAELTLD
0	1	-	gap
0	2	P205	VFTSRRLPATLLNAF
0	6	S217-p	NAFPTAPsPRPPRKA
0	4	Y271-p	KSLLETQyQNVRGRP
0	1	R275	ETQyQNVRGRPIFWM

	NAT6 iso2

T14-p	SPGPAKLtPTLDPTH
S30	MELILSTSPAELTLD
-	gap
P227	VFTSRRLPATLLNAF
S239	NAFPTAPSPRPPRKA
Y293	KSLLETQYQNVRGRP
R297	ETQYQNVRGRPIFWM

	mouse

-	gap
S8-p	MELILSTsPAKLTLD
S44-p	RQPELSLsPRLAELT
S233-p	AFTNRRLsTTVLRAF
C245	RAFSKPPCPQPPCKE
Y299	QSPLETCYRDLkGCP
K303-a	ETCYRDLkGCPIFWM

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