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Smad4
transcription factor that mediates signal transduction by the transforming growth factor superfamily. The common smad (co-smad). Binds directly to consensus DNA-binding elements in the promoters of target genes. Promotes binding of the Smad2/Smad4/Fast-1 complex to DNA and provides an activation function required for Smad1 or Smad2 to stimulate transcription. Note: This description may include information from UniProtKB.
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| Protein type: DNA binding protein; Transcription, coactivator/corepressor |
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Cellular Component: nucleoplasm; centrosome; transcription factor complex; cytoplasm; nucleolus; cytosol; nucleus
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Molecular Function: collagen binding; identical protein binding; protein binding; protein homodimerization activity; transforming growth factor beta receptor, common-partner cytoplasmic mediator activity; DNA binding; sequence-specific DNA binding; chromatin binding; transcription factor activity
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Biological Process: developmental growth; positive regulation of transcription, DNA-dependent; sebaceous gland development; palate development; negative regulation of transcription from RNA polymerase II promoter; BMP signaling pathway; negative regulation of cell proliferation; regulation of transforming growth factor beta receptor signaling pathway; transforming growth factor beta receptor signaling pathway; mesoderm development; neural crest cell differentiation; positive regulation of BMP signaling pathway; transcription initiation from RNA polymerase II promoter; regulation of transforming growth factor-beta2 production; transcription, DNA-dependent; regulation of binding; in utero embryonic development; positive regulation of transforming growth factor beta receptor signaling pathway; neuron fate commitment; gastrulation with mouth forming second; somite rostral/caudal axis specification; formation of anatomical boundary; SMAD protein complex assembly; cell proliferation; ureteric bud branching; response to hypoxia; gene expression; positive regulation of transcription from RNA polymerase II promoter; regulation of hair follicle development; negative regulation of cell growth; negative regulation of protein catabolic process; negative regulation of transcription, DNA-dependent; endoderm development
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Reference #:
Q13485 (UniProtKB)
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| Alt. Names/Synonyms: deleted in pancreatic carcinoma locus 4; Deletion target in pancreatic carcinoma 4; DPC4; hSMAD4; JIP; MAD homolog 4; MAD, mothers against decapentaplegic homolog 4; MADH4; Mothers against decapentaplegic homolog 4; mothers against decapentaplegic, Drosophila, homolog of, 4; Mothers against DPP homolog 4; SMAD 4; SMAD family member 4; SMAD, mothers against DPP homolog 4; SMAD4 |
| Gene Symbols: SMAD4 |
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Molecular weight: 60,439 Da
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Basal Isoelectric point: 6.5
Predict pI for various phosphorylation states
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CST Pathways:
Cell Cycle: G1/S Checkpoint
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ESC Pluripotency and Differentiation
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SAPK/JNK Signaling Cascades
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TGF-ß Signaling
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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