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Protein Page:
TCL1A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TCL1A Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity. Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation. Belongs to the TCL1 family. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, regulatory subunit
Cellular Component: endoplasmic reticulum; pronucleus; cell cortex
Molecular Function: protein binding
Biological Process: multicellular organismal development; stem cell maintenance
Reference #:  P56279 (UniProtKB)
Alt. Names/Synonyms: Oncogene TCL-1; Oncogene TCL1; Protein p14 TCL1; T-cell leukemia/lymphoma 1A; T-cell leukemia/lymphoma protein 1A; T-cell lymphoma-1; T-cell lymphoma-1A; TCL1; TCL1A
Gene Symbols: TCL1A
Molecular weight: 13,460 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TCL1A

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K42 LPLTIEIKDRLQLRV
0 5 T63-p VVLGRPMtPtQIGPS
0 4 T65-p LGRPMtPtQIGPSLL
0 1 Y96-p SSFWRLVyHIKIDGV
  mouse

 
K40-ub SWLPVVIkSNEKFQV
S61 VTLGEAMSPSQLVPY
S63 LGEAMSPSQLVPYEL
Y94 SMYWQILYHIKFRDV
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